Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2863
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 39
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR39
Synonyms (NCBI Gene) Gene synonyms aliases	ZnR
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein

Show/Hide all(110)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029962	hsa-miR-26b-5p	Microarray	19088304
MIRT736805	hsa-miR-1914-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	31576658
MIRT1031367	hsa-miR-1252	CLIP-seq
MIRT1031368	hsa-miR-1260	CLIP-seq
MIRT1031369	hsa-miR-1260b	CLIP-seq
MIRT1031370	hsa-miR-1296	CLIP-seq
MIRT1031371	hsa-miR-188-3p	CLIP-seq
MIRT1031372	hsa-miR-1914	CLIP-seq
MIRT1031373	hsa-miR-1976	CLIP-seq
MIRT1031374	hsa-miR-19a	CLIP-seq
MIRT1031375	hsa-miR-19b	CLIP-seq
MIRT1031376	hsa-miR-2116	CLIP-seq
MIRT1031377	hsa-miR-2117	CLIP-seq
MIRT1031378	hsa-miR-2909	CLIP-seq
MIRT1031379	hsa-miR-3135b	CLIP-seq
MIRT1031380	hsa-miR-3156-3p	CLIP-seq
MIRT1031381	hsa-miR-3158-3p	CLIP-seq
MIRT1031382	hsa-miR-3173-3p	CLIP-seq
MIRT1031383	hsa-miR-33a	CLIP-seq
MIRT1031384	hsa-miR-33b	CLIP-seq
MIRT1031385	hsa-miR-3652	CLIP-seq
MIRT1031386	hsa-miR-3689d	CLIP-seq
MIRT1031387	hsa-miR-375	CLIP-seq
MIRT1031388	hsa-miR-3922-5p	CLIP-seq
MIRT1031389	hsa-miR-4273	CLIP-seq
MIRT1031390	hsa-miR-4301	CLIP-seq
MIRT1031391	hsa-miR-4326	CLIP-seq
MIRT1031392	hsa-miR-4430	CLIP-seq
MIRT1031393	hsa-miR-4446-3p	CLIP-seq
MIRT1031394	hsa-miR-4476	CLIP-seq
MIRT1031395	hsa-miR-4477a	CLIP-seq
MIRT1031396	hsa-miR-4492	CLIP-seq
MIRT1031397	hsa-miR-4498	CLIP-seq
MIRT1031398	hsa-miR-4533	CLIP-seq
MIRT1031399	hsa-miR-4635	CLIP-seq
MIRT1031400	hsa-miR-4640-3p	CLIP-seq
MIRT1031401	hsa-miR-4640-5p	CLIP-seq
MIRT1031402	hsa-miR-4667-3p	CLIP-seq
MIRT1031403	hsa-miR-4677-5p	CLIP-seq
MIRT1031404	hsa-miR-4715-3p	CLIP-seq
MIRT1031405	hsa-miR-4726-5p	CLIP-seq
MIRT1031406	hsa-miR-4753-3p	CLIP-seq
MIRT1031407	hsa-miR-762	CLIP-seq
MIRT2005963	hsa-miR-1224-3p	CLIP-seq
MIRT2005964	hsa-miR-125a-5p	CLIP-seq
MIRT2005965	hsa-miR-125b	CLIP-seq
MIRT1031368	hsa-miR-1260	CLIP-seq
MIRT1031369	hsa-miR-1260b	CLIP-seq
MIRT1031370	hsa-miR-1296	CLIP-seq
MIRT1031371	hsa-miR-188-3p	CLIP-seq
MIRT1031378	hsa-miR-2909	CLIP-seq
MIRT1031379	hsa-miR-3135b	CLIP-seq
MIRT1031380	hsa-miR-3156-3p	CLIP-seq
MIRT1031381	hsa-miR-3158-3p	CLIP-seq
MIRT2005966	hsa-miR-3174	CLIP-seq
MIRT1031385	hsa-miR-3652	CLIP-seq
MIRT1031388	hsa-miR-3922-5p	CLIP-seq
MIRT1031390	hsa-miR-4301	CLIP-seq
MIRT2005967	hsa-miR-4319	CLIP-seq
MIRT1031392	hsa-miR-4430	CLIP-seq
MIRT1031393	hsa-miR-4446-3p	CLIP-seq
MIRT1031396	hsa-miR-4492	CLIP-seq
MIRT1031397	hsa-miR-4498	CLIP-seq
MIRT1031401	hsa-miR-4640-5p	CLIP-seq
MIRT1031405	hsa-miR-4726-5p	CLIP-seq
MIRT2005968	hsa-miR-4732-3p	CLIP-seq
MIRT2005969	hsa-miR-4753-5p	CLIP-seq
MIRT2005970	hsa-miR-4755-3p	CLIP-seq
MIRT2005971	hsa-miR-4765	CLIP-seq
MIRT2005972	hsa-miR-654-3p	CLIP-seq
MIRT2005973	hsa-miR-670	CLIP-seq
MIRT1031407	hsa-miR-762	CLIP-seq
MIRT2238526	hsa-miR-122	CLIP-seq
MIRT1031367	hsa-miR-1252	CLIP-seq
MIRT2238527	hsa-miR-2053	CLIP-seq
MIRT2238528	hsa-miR-3129-3p	CLIP-seq
MIRT2238529	hsa-miR-3140-3p	CLIP-seq
MIRT2238530	hsa-miR-3672	CLIP-seq
MIRT2238531	hsa-miR-3945	CLIP-seq
MIRT2238532	hsa-miR-4315	CLIP-seq
MIRT2238533	hsa-miR-4328	CLIP-seq
MIRT2238534	hsa-miR-4790-5p	CLIP-seq
MIRT2238535	hsa-miR-548a-3p	CLIP-seq
MIRT2238536	hsa-miR-548e	CLIP-seq
MIRT2238537	hsa-miR-548f	CLIP-seq
MIRT2005972	hsa-miR-654-3p	CLIP-seq
MIRT2005963	hsa-miR-1224-3p	CLIP-seq
MIRT1031373	hsa-miR-1976	CLIP-seq
MIRT1031376	hsa-miR-2116	CLIP-seq
MIRT1031383	hsa-miR-33a	CLIP-seq
MIRT1031384	hsa-miR-33b	CLIP-seq
MIRT1031389	hsa-miR-4273	CLIP-seq
MIRT2450627	hsa-miR-4314	CLIP-seq
MIRT1031400	hsa-miR-4640-3p	CLIP-seq
MIRT1031402	hsa-miR-4667-3p	CLIP-seq
MIRT1031403	hsa-miR-4677-5p	CLIP-seq
MIRT2450628	hsa-miR-4687-5p	CLIP-seq
MIRT1031404	hsa-miR-4715-3p	CLIP-seq
MIRT2005963	hsa-miR-1224-3p	CLIP-seq
MIRT1031373	hsa-miR-1976	CLIP-seq
MIRT1031376	hsa-miR-2116	CLIP-seq
MIRT1031383	hsa-miR-33a	CLIP-seq
MIRT1031384	hsa-miR-33b	CLIP-seq
MIRT1031389	hsa-miR-4273	CLIP-seq
MIRT2450627	hsa-miR-4314	CLIP-seq
MIRT1031400	hsa-miR-4640-3p	CLIP-seq
MIRT1031402	hsa-miR-4667-3p	CLIP-seq
MIRT1031403	hsa-miR-4677-5p	CLIP-seq
MIRT2450628	hsa-miR-4687-5p	CLIP-seq
MIRT1031404	hsa-miR-4715-3p	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
HNF1A	Unknown	17488974
HNF4A	Unknown	17488974
SP1	Unknown	17488974

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	26365466
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	9441746
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
602886	4496	ENSG00000183840

Protein

UniProt ID

O43194

Protein name

G-protein coupled receptor 39

Protein function

Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility,

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	47 → 344	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many tissues, including the stomach, intestine and hypothalamus. {ECO:0000269|PubMed:9441746}.

Sequence

MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQK
KGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSY
ATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPL
VNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAF
MCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQ
IRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLC
CRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQ
SKSQSLSLESLEPNSGAKPANSAAENGFQEHEV

Sequence length

453

Interactions

View interactions

	Reactome
			Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Hypertension	Hypertensive disease	rs13306026	21626137
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	29802348
Carcinoma Squamous Cell	Associate	37839873
Diabetes Mellitus Type 2	Inhibit	17371481
Hepatitis B	Associate	32784555
Hypertension	Associate	21626137
Inflammation	Inhibit	31237151
Lymphatic Metastasis	Associate	37839873
Migraine Disorders	Associate	31842742
Muscular Atrophy	Associate	33687156
Neoplasms	Associate	19696931, 26716511, 29802348
Obesity	Inhibit	17371481
Obesity	Associate	29976977
Osteoarthritis	Associate	31237151
Stomach Neoplasms	Associate	26716511
Wilms Tumor	Associate	19696931

GPR39 (G protein-coupled receptor 39)