GPR18 (G protein-coupled receptor 18)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2841
Gene name Gene Name - the full gene name approved by the HGNC.
G protein-coupled receptor 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPR18
Synonyms (NCBI Gene) Gene synonyms aliases
DRV2
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.3
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004930 Function G protein-coupled receptor activity NAS 9205118
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007186 Process G protein-coupled receptor signaling pathway NAS 9205118
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602042 4472 ENSG00000125245
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14330
Protein name N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18)
Protein function G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725). Becomes active when triggered by various endogenous ligands including e
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 39 → 286 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083). {ECO
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Inflammatory bowel disease Inflammatory Bowel Diseases rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 26192919
Show/Hide Unknown Diseases (4)
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease 26192919 ClinVar
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Ulcerative colitis Ulcerative colitis GWAS
Crohn Disease Crohn Disease GWAS
Show/Hide Text Mining Associations (10)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 24098497
Communication Disorders Associate 34484417
Fluorosis Dental Associate 29317700
Hyperlipoproteinemia Type II Associate 35163351
Kashin Beck Disease Associate 29317700
Neoplasms Associate 32398659
Periodontitis Associate 32670289
Pulmonary Arterial Hypertension Associate 35163351
Sarcoidosis Associate 32701935
Sepsis Associate 34484417