TTLL6 (tubulin tyrosine ligase like 6)

Gene

• Entrez ID: 284076
• Gene name: Tubulin tyrosine ligase like 6
• Gene symbol: TTLL6
• Synonyms (NCBI Gene): TTL.6
• Chromosome: 17
• Chromosome location: 17q21.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2359822	hsa-miR-141	CLIP-seq
MIRT2359823	hsa-miR-200a	CLIP-seq
MIRT2359824	hsa-miR-4677-3p	CLIP-seq
MIRT2359825	hsa-miR-4679	CLIP-seq
MIRT2359826	hsa-miR-4778-5p	CLIP-seq
MIRT2442778	hsa-miR-1226	CLIP-seq
MIRT2442779	hsa-miR-1321	CLIP-seq
MIRT2442780	hsa-miR-138	CLIP-seq
MIRT2442781	hsa-miR-1587	CLIP-seq
MIRT2442782	hsa-miR-3126-5p	CLIP-seq
MIRT2442783	hsa-miR-4299	CLIP-seq
MIRT2442784	hsa-miR-4419a	CLIP-seq
MIRT2442785	hsa-miR-4492	CLIP-seq
MIRT2442786	hsa-miR-4498	CLIP-seq
MIRT2442787	hsa-miR-4510	CLIP-seq
MIRT2442788	hsa-miR-4656	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2442790	hsa-miR-4710	CLIP-seq
MIRT2442791	hsa-miR-4733-3p	CLIP-seq
MIRT2442792	hsa-miR-4739	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2442794	hsa-miR-4756-5p	CLIP-seq
MIRT2442795	hsa-miR-4792	CLIP-seq
MIRT2442796	hsa-miR-762	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0003353	Process	Positive regulation of cilium movement	IEA
GO:0005515	Function	Protein binding	IPI	22246503
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IDA
GO:0005929	Component	Cilium	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0015631	Function	Tubulin binding	IBA
GO:0015631	Function	Tubulin binding	IEA
GO:0015631	Function	Tubulin binding	ISS
GO:0016874	Function	Ligase activity	IEA
GO:0018095	Process	Protein polyglutamylation	ISS
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IDA	22246503
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051013	Process	Microtubule severing	IEA
GO:0060296	Process	Regulation of cilium beat frequency involved in ciliary motility	IEA
GO:0060296	Process	Regulation of cilium beat frequency involved in ciliary motility	ISS
GO:0070739	Function	Protein-glutamic acid ligase activity	IEA
GO:0070739	Function	Protein-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	TAS
GO:0097731	Component	9+0 non-motile cilium	IEA
GO:0106437	Function	Protein-glutamic acid ligase activity, initiating	IEA
GO:0106438	Function	Protein-glutamic acid ligase activity, elongating	IEA

Other IDs

• MIM: 610849
• HGNC: 26664
• e!Ensembl: ENSG00000170703

Protein

• UniProt ID: Q8N841
• Protein name: Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)
• Protein function: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long pol
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	104 → 398	Tubulin-tyrosine ligase family	Family

• Sequence:

  MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKR
  LVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGM
  SEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGC
  QGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGL
  ARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYN
  VEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLE
  VNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRI
  EEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEY
  ARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQY
  IQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNI
  NLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVT
  ASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMN
  KPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVS
  SLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGC
  ERS

• Sequence length: 843

Pathways

Reactome:

Carboxyterminal post-translational modifications of tubulin

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Diabetes Mellitus Type 2	Associate	30956117
Neoplasms	Associate	35333353