Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	284076
Gene name Gene Name - the full gene name approved by the HGNC.	Tubulin tyrosine ligase like 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TTLL6
Synonyms (NCBI Gene) Gene synonyms aliases	TTL.6
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32

Show/Hide all(44)

miRTarBase ID	miRNA	Experiments
MIRT2359822	hsa-miR-141	CLIP-seq
MIRT2359823	hsa-miR-200a	CLIP-seq
MIRT2359824	hsa-miR-4677-3p	CLIP-seq
MIRT2359825	hsa-miR-4679	CLIP-seq
MIRT2359826	hsa-miR-4778-5p	CLIP-seq
MIRT2442778	hsa-miR-1226	CLIP-seq
MIRT2442779	hsa-miR-1321	CLIP-seq
MIRT2442780	hsa-miR-138	CLIP-seq
MIRT2442781	hsa-miR-1587	CLIP-seq
MIRT2442782	hsa-miR-3126-5p	CLIP-seq
MIRT2442783	hsa-miR-4299	CLIP-seq
MIRT2442784	hsa-miR-4419a	CLIP-seq
MIRT2442785	hsa-miR-4492	CLIP-seq
MIRT2442786	hsa-miR-4498	CLIP-seq
MIRT2442787	hsa-miR-4510	CLIP-seq
MIRT2442788	hsa-miR-4656	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2442790	hsa-miR-4710	CLIP-seq
MIRT2442791	hsa-miR-4733-3p	CLIP-seq
MIRT2442792	hsa-miR-4739	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2442794	hsa-miR-4756-5p	CLIP-seq
MIRT2442795	hsa-miR-4792	CLIP-seq
MIRT2442796	hsa-miR-762	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0003353	Process	Positive regulation of cilium movement	IEA
GO:0005515	Function	Protein binding	IPI	22246503
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IBA	21873635
GO:0015631	Function	Tubulin binding	IBA	21873635
GO:0015631	Function	Tubulin binding	ISS
GO:0018095	Process	Protein polyglutamylation	IBA	21873635
GO:0018095	Process	Protein polyglutamylation	ISS
GO:0018095	Process	Protein polyglutamylation	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0036064	Component	Ciliary basal body	IDA	22246503
GO:0051013	Process	Microtubule severing	IEA
GO:0070739	Function	Protein-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA	21873635
GO:0097731	Component	9+0 non-motile cilium	IEA

MIM	HGNC	e!Ensembl
610849	26664	ENSG00000170703

Protein

UniProt ID

Q8N841

Protein name

Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)

Protein function

Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long pol

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03133	TTL	104 → 398	Tubulin-tyrosine ligase family	Family

Sequence

MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKR
LVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGM
SEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGC
QGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGL
ARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYN
VEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLE
VNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRI
EEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEY
ARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQY
IQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNI
NLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVT
ASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMN
KPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVS
SLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGC
ERS

Sequence length

843

Interactions

View interactions

	Reactome
			Carboxyterminal post-translational modifications of tubulin

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	29632382
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	24280982

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Myocardial Infarction	Myocardial Infarction	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Diabetes Mellitus Type 2	Associate	30956117
Neoplasms	Associate	35333353

TTLL6 (tubulin tyrosine ligase like 6)