Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
283871
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphoglycolate phosphatase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PGP
Synonyms (NCBI Gene) Gene synonyms aliases
AUM, G3PP, PGPase
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT048822 hsa-miR-93-5p CLASH 23622248
MIRT1227962 hsa-miR-106a CLIP-seq
MIRT1227963 hsa-miR-106b CLIP-seq
MIRT1227964 hsa-miR-1197 CLIP-seq
MIRT1227965 hsa-miR-1233 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000121 Function Glycerol-1-phosphatase activity IEA
GO:0000287 Function Magnesium ion binding ISS
GO:0004725 Function Protein tyrosine phosphatase activity ISS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0006114 Process Glycerol biosynthetic process IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
172280 8909 ENSG00000184207
Protein
UniProt ID A6NDG6
Protein name Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP)
Protein function Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphog
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13344 Hydrolase_6 31 139 Haloacid dehalogenase-like hydrolase Domain
PF13242 Hydrolase_like 232 315 Domain
Tissue specificity TISSUE SPECIFICITY: Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle. {ECO:0000269|PubMed:215071}.
Sequence
MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARG
KRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPK
AYVLGSPALAAELEAVGVA
SVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMK
LTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFI
FDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSK
KKMVPDFYVDSIADL
LPALQG
Sequence length 321
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Glyoxylate and dicarboxylate metabolism
Metabolic pathways
Carbon metabolism
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Achalasia Addisonianism Alacrimia syndrome Associate 26234720
Alzheimer Disease Inhibit 32885413, 40023574
Alzheimer Disease Associate 33115695
Arthritis Rheumatoid Associate 36724603
Autoimmune Diseases Inhibit 40023574
Bacterial Infections Associate 33427563
Breast Neoplasms Associate 16925584, 17912240, 19940361, 22521303, 22615870, 24368600, 25973019, 26279432, 26722437, 28131717, 30292104, 35449387, 40332431
Breast Neoplasms Stimulate 36867605, 9180147
Calcinosis Cutis Associate 28131717
Cancer Pain Associate 19079610