GP2 (glycoprotein 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 2813 |
| Gene name | Glycoprotein 2 |
| Gene symbol | GP2 |
| Synonyms (NCBI Gene) |
ZAP75
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| Chromosome | 16 |
| Chromosome location | 16p12.3 |
| Summary | This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby |
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miRNA
miRNA information provided by mirtarbase database.
398
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P55259 | ||||||||||
| Protein name | Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) | ||||||||||
| Protein function | Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type | ||||||||||
| PDB | 7P6R , 7P6S , 7P6T | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in pancreas (at protein level) (PubMed:10760606, PubMed:8666297). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495). {ECO:0000269|PubMed:10 | ||||||||||
| Sequence |
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| Sequence length | 537 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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