GNG11 (G protein subunit gamma 11)

Gene

• Entrez ID: 2791
• Gene name: G protein subunit gamma 11
• Gene symbol: GNG11
• Synonyms (NCBI Gene): GNGT11, HG3H1
• Chromosome: 7
• Chromosome location: 7q21.3
• Summary: This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling sy

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2236514	hsa-miR-127-5p	CLIP-seq
MIRT2236515	hsa-miR-3942-5p	CLIP-seq
MIRT2236516	hsa-miR-4703-5p	CLIP-seq
MIRT2540245	hsa-miR-1265	CLIP-seq
MIRT2540246	hsa-miR-1298	CLIP-seq
MIRT2540247	hsa-miR-150	CLIP-seq
MIRT2540248	hsa-miR-153	CLIP-seq
MIRT2540249	hsa-miR-217	CLIP-seq
MIRT2540250	hsa-miR-2392	CLIP-seq
MIRT2540251	hsa-miR-3126-3p	CLIP-seq
MIRT2540252	hsa-miR-3140-3p	CLIP-seq
MIRT2540253	hsa-miR-3168	CLIP-seq
MIRT2540254	hsa-miR-3174	CLIP-seq
MIRT2540255	hsa-miR-3192	CLIP-seq
MIRT2540256	hsa-miR-3653	CLIP-seq
MIRT2540257	hsa-miR-3658	CLIP-seq
MIRT2540258	hsa-miR-3667-3p	CLIP-seq
MIRT2540259	hsa-miR-3907	CLIP-seq
MIRT2540260	hsa-miR-4314	CLIP-seq
MIRT2540261	hsa-miR-4422	CLIP-seq
MIRT2540262	hsa-miR-4436b-5p	CLIP-seq
MIRT2540263	hsa-miR-4646-5p	CLIP-seq
MIRT2540264	hsa-miR-4713-5p	CLIP-seq
MIRT2540265	hsa-miR-4720-3p	CLIP-seq
MIRT2540266	hsa-miR-4775	CLIP-seq
MIRT2540267	hsa-miR-4781-3p	CLIP-seq
MIRT2540268	hsa-miR-4789-5p	CLIP-seq
MIRT2540269	hsa-miR-4804-3p	CLIP-seq
MIRT2540270	hsa-miR-495	CLIP-seq
MIRT2540271	hsa-miR-532-3p	CLIP-seq
MIRT2540272	hsa-miR-548u	CLIP-seq
MIRT2540273	hsa-miR-651	CLIP-seq
MIRT2540274	hsa-miR-767-3p	CLIP-seq
MIRT2540275	hsa-miR-921	CLIP-seq
MIRT2540245	hsa-miR-1265	CLIP-seq
MIRT2540246	hsa-miR-1298	CLIP-seq
MIRT2540247	hsa-miR-150	CLIP-seq
MIRT2540248	hsa-miR-153	CLIP-seq
MIRT2540249	hsa-miR-217	CLIP-seq
MIRT2540250	hsa-miR-2392	CLIP-seq
MIRT2540251	hsa-miR-3126-3p	CLIP-seq
MIRT2540252	hsa-miR-3140-3p	CLIP-seq
MIRT2681741	hsa-miR-3153	CLIP-seq
MIRT2540253	hsa-miR-3168	CLIP-seq
MIRT2540254	hsa-miR-3174	CLIP-seq
MIRT2540255	hsa-miR-3192	CLIP-seq
MIRT2540256	hsa-miR-3653	CLIP-seq
MIRT2540257	hsa-miR-3658	CLIP-seq
MIRT2540258	hsa-miR-3667-3p	CLIP-seq
MIRT2540259	hsa-miR-3907	CLIP-seq
MIRT2540260	hsa-miR-4314	CLIP-seq
MIRT2540261	hsa-miR-4422	CLIP-seq
MIRT2540262	hsa-miR-4436b-5p	CLIP-seq
MIRT2540263	hsa-miR-4646-5p	CLIP-seq
MIRT2681742	hsa-miR-4668-5p	CLIP-seq
MIRT2540264	hsa-miR-4713-5p	CLIP-seq
MIRT2540265	hsa-miR-4720-3p	CLIP-seq
MIRT2540266	hsa-miR-4775	CLIP-seq
MIRT2540267	hsa-miR-4781-3p	CLIP-seq
MIRT2540268	hsa-miR-4789-5p	CLIP-seq
MIRT2540269	hsa-miR-4804-3p	CLIP-seq
MIRT2540270	hsa-miR-495	CLIP-seq
MIRT2540271	hsa-miR-532-3p	CLIP-seq
MIRT2540272	hsa-miR-548u	CLIP-seq
MIRT2540273	hsa-miR-651	CLIP-seq
MIRT2540274	hsa-miR-767-3p	CLIP-seq
MIRT2540275	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	TAS	7665596
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	7665596
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0031681	Function	G-protein beta-subunit binding	IBA
GO:0031681	Function	G-protein beta-subunit binding	IEA

Other IDs

• MIM: 604390
• HGNC: 4403
• e!Ensembl: ENSG00000127920

Protein

• UniProt ID: P61952
• Protein name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
• Protein function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00631	G-gamma	9 → 73	GGL domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Abundantly expressed in all tissues tested except for brain.
• Sequence:

  MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPED
  KNPFKEKGSCVIS

• Sequence length: 73

Pathways

KEGG:

Ras signaling pathway
Chemokine signaling pathway
Hormone signaling
PI3K-Akt signaling pathway
Apelin signaling pathway
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Relaxin signaling pathway
Morphine addiction
Alcoholism
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer

Reactome:

Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits