Gene Gene information from NCBI Gene database.
Entrez ID 27436
Gene name EMAP like 4
Gene symbol EML4
Synonyms (NCBI Gene)
C2orf2ELP120EMAP-4EMAPL4ROPP120
Chromosome 2
Chromosome location 2p21
Summary This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine ki
miRNA miRNA information provided by mirtarbase database.
592
miRTarBase ID miRNA Experiments Reference
MIRT002765 hsa-miR-1-3p Microarray 15685193
MIRT023446 hsa-miR-30b-5p Sequencing 20371350
MIRT002765 hsa-miR-1-3p Microarray;Other 15685193
MIRT031894 hsa-miR-16-5p Proteomics 18668040
MIRT043596 hsa-miR-148b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0000278 Process Mitotic cell cycle NAS 10995578
GO:0005515 Function Protein binding IPI 25789526
GO:0005737 Component Cytoplasm IDA 16890222
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607442 1316 ENSG00000143924
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HC35
Protein name Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)
Protein function Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruit
PDB 4CGC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03451 HELP 225 297 HELP motif Family
PF00400 WD40 299 347 WD domain, G-beta repeat Repeat
PF00400 WD40 499 537 WD domain, G-beta repeat Repeat
PF00400 WD40 583 620 WD domain, G-beta repeat Repeat
PF00400 WD40 711 749 WD domain, G-beta repeat Repeat
PF00400 WD40 824 863 WD domain, G-beta repeat Repeat
Sequence
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI
PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNY
EER
TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLG
TFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT
DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML
IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL
NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT
HPFKDLLLTCAQDRQVCLWN
SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL
DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH
SSYITHLDWSPDNKYIMSNSGDYEILYWD
IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF
GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV
SFTHNDSHLISTGGKDMSIIQWK
LVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP
PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE
ISKEQAKATLLEDQQDPSPSS
Sequence length 981
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Pathways in cancer
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
  EML4 and NUDC in mitotic spindle formation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EML4-related disorder Likely benign rs113909364, rs143932826 RCV003906835
RCV003958950
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 22124476, 22323876, 22706607, 22768234, 25588859, 29199691, 37340599
Adenocarcinoma Mucinous Associate 23617234
Adenocarcinoma of Lung Associate 20179225, 20624322, 21921848, 23289484, 23408463, 23617234, 24755712, 24935562, 25178493, 25695223, 26045865, 26301689, 26666609, 27472693, 27613526
View all (24 more)
Arthritis Rheumatoid Associate 35008858
Calcinosis Cutis Associate 26850068
Carcinoid Tumor Associate 31559892
Carcinoma Associate 35900506
Carcinoma Adenosquamous Associate 35818908
Carcinoma Non Small Cell Lung Associate 18166835, 18320074, 18414414, 19170230, 19737969, 20979469, 20979473, 21103621, 21656749, 21767331, 22124476, 22240786, 22296236, 22323876, 22706607
View all (50 more)
Carcinoma Renal Cell Associate 32467651