Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27436
Gene name Gene Name - the full gene name approved by the HGNC.
EMAP like 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EML4
Synonyms (NCBI Gene) Gene synonyms aliases
C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine ki
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002765 hsa-miR-1-3p Microarray 15685193
MIRT023446 hsa-miR-30b-5p Sequencing 20371350
MIRT002765 hsa-miR-1-3p Microarray;Other 15685193
MIRT031894 hsa-miR-16-5p Proteomics 18668040
MIRT043596 hsa-miR-148b-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0000278 Process Mitotic cell cycle NAS 10995578
GO:0005515 Function Protein binding IPI 25789526
GO:0005737 Component Cytoplasm IDA 16890222
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607442 1316 ENSG00000143924
Protein
UniProt ID Q9HC35
Protein name Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)
Protein function Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruit
PDB 4CGC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03451 HELP 225 297 HELP motif Family
PF00400 WD40 299 347 WD domain, G-beta repeat Repeat
PF00400 WD40 499 537 WD domain, G-beta repeat Repeat
PF00400 WD40 583 620 WD domain, G-beta repeat Repeat
PF00400 WD40 711 749 WD domain, G-beta repeat Repeat
PF00400 WD40 824 863 WD domain, G-beta repeat Repeat
Sequence
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFI
PSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNY
EER
TQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLG
TFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPT
DANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVML
IWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL
NPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLAT
HPFKDLLLTCAQDRQVCLWN
SMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVL
DAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGH
SSYITHLDWSPDNKYIMSNSGDYEILYWD
IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVF
GVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNV
SFTHNDSHLISTGGKDMSIIQWK
LVEKLSLPQNETVADTTLTKAPVSSTESVIQSNTPTP
PPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNE
ISKEQAKATLLEDQQDPSPSS
Sequence length 981
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pathways in cancer
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
  EML4 and NUDC in mitotic spindle formation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypospadias Hypospadias N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 22124476, 22323876, 22706607, 22768234, 25588859, 29199691, 37340599
Adenocarcinoma Mucinous Associate 23617234
Adenocarcinoma of Lung Associate 20179225, 20624322, 21921848, 23289484, 23408463, 23617234, 24755712, 24935562, 25178493, 25695223, 26045865, 26301689, 26666609, 27472693, 27613526
View all (24 more)
Arthritis Rheumatoid Associate 35008858
Calcinosis Cutis Associate 26850068
Carcinoid Tumor Associate 31559892
Carcinoma Associate 35900506
Carcinoma Adenosquamous Associate 35818908
Carcinoma Non Small Cell Lung Associate 18166835, 18320074, 18414414, 19170230, 19737969, 20979469, 20979473, 21103621, 21656749, 21767331, 22124476, 22240786, 22296236, 22323876, 22706607
View all (50 more)
Carcinoma Renal Cell Associate 32467651