Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27346
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane protein 97
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMEM97
Synonyms (NCBI Gene) Gene synonyms aliases
MAC30, S2R, sigma2R
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025807 hsa-miR-7-5p Microarray 17612493
MIRT025807 hsa-miR-7-5p Microarray 19073608
MIRT050502 hsa-miR-20a-5p CLASH 23622248
MIRT041579 hsa-miR-193b-3p CLASH 23622248
MIRT039218 hsa-miR-769-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth NAS 7694637
GO:0005515 Function Protein binding IPI 19583955, 32296183
GO:0005764 Component Lysosome IDA 19583955
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005783 Component Endoplasmic reticulum IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612912 28106 ENSG00000109084
Protein
UniProt ID Q5BJF2
Protein name Sigma intracellular receptor 2 (S2R) (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (MAC30) (Transmembrane protein 97)
Protein function Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-boun
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05241 EBP 43 161 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215). {ECO:0000269|PubMed:15375745, ECO:0000
Sequence
Sequence length 176
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Neuroactive ligand-receptor interaction  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Age-related macular degeneration Age related macular degeneration rs199474657, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152
View all (20 more)
26691988
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Associate 23229099, 26376695, 27688262
Colonic Neoplasms Associate 33985413
Frontotemporal Dementia Associate 37979250
Glioblastoma Associate 38167429
Glioma Associate 26002575
Glioma of Brain Familial Associate 30940290
Lymphatic Metastasis Stimulate 23229099, 27268655, 27688262
Macular Degeneration Associate 36834828
Mucopolysaccharidosis I Inhibit 32880920
Neoplasm Metastasis Associate 26002575