Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27339
Gene name Gene Name - the full gene name approved by the HGNC.	Pre-mRNA processing factor 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRPF19
Synonyms (NCBI Gene) Gene synonyms aliases	NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.2
Summary Summary of gene provided in NCBI Entrez Gene.	PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

Show/Hide all(83)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051973	hsa-let-7b-5p	CLASH	23622248
MIRT049927	hsa-miR-30a-5p	CLASH	23622248
MIRT041329	hsa-miR-193b-3p	CLASH	23622248
MIRT1265325	hsa-miR-1273f	CLIP-seq
MIRT1265326	hsa-miR-128	CLIP-seq
MIRT1265327	hsa-miR-143	CLIP-seq
MIRT1265328	hsa-miR-1976	CLIP-seq
MIRT1265329	hsa-miR-203	CLIP-seq
MIRT1265330	hsa-miR-204	CLIP-seq
MIRT1265331	hsa-miR-211	CLIP-seq
MIRT1265332	hsa-miR-24	CLIP-seq
MIRT1265333	hsa-miR-27a	CLIP-seq
MIRT1265334	hsa-miR-27b	CLIP-seq
MIRT1265335	hsa-miR-28-3p	CLIP-seq
MIRT1265336	hsa-miR-3127-3p	CLIP-seq
MIRT1265337	hsa-miR-4284	CLIP-seq
MIRT1265338	hsa-miR-4290	CLIP-seq
MIRT1265339	hsa-miR-4667-3p	CLIP-seq
MIRT1265340	hsa-miR-4687-5p	CLIP-seq
MIRT1265341	hsa-miR-4708-5p	CLIP-seq
MIRT1265342	hsa-miR-4738-3p	CLIP-seq
MIRT1265343	hsa-miR-4755-5p	CLIP-seq
MIRT1265344	hsa-miR-4770	CLIP-seq
MIRT1265345	hsa-miR-4780	CLIP-seq
MIRT1265346	hsa-miR-513a-5p	CLIP-seq
MIRT1265347	hsa-miR-520d-5p	CLIP-seq
MIRT1265348	hsa-miR-524-5p	CLIP-seq
MIRT1265349	hsa-miR-623	CLIP-seq
MIRT1265350	hsa-miR-759	CLIP-seq
MIRT1265326	hsa-miR-128	CLIP-seq
MIRT1265328	hsa-miR-1976	CLIP-seq
MIRT1265330	hsa-miR-204	CLIP-seq
MIRT1265331	hsa-miR-211	CLIP-seq
MIRT1265332	hsa-miR-24	CLIP-seq
MIRT1265333	hsa-miR-27a	CLIP-seq
MIRT1265334	hsa-miR-27b	CLIP-seq
MIRT1265335	hsa-miR-28-3p	CLIP-seq
MIRT1265336	hsa-miR-3127-3p	CLIP-seq
MIRT1265337	hsa-miR-4284	CLIP-seq
MIRT1265338	hsa-miR-4290	CLIP-seq
MIRT2078020	hsa-miR-4641	CLIP-seq
MIRT1265339	hsa-miR-4667-3p	CLIP-seq
MIRT1265340	hsa-miR-4687-5p	CLIP-seq
MIRT2078021	hsa-miR-4722-3p	CLIP-seq
MIRT1265342	hsa-miR-4738-3p	CLIP-seq
MIRT1265343	hsa-miR-4755-5p	CLIP-seq
MIRT1265345	hsa-miR-4780	CLIP-seq
MIRT1265346	hsa-miR-513a-5p	CLIP-seq
MIRT1265347	hsa-miR-520d-5p	CLIP-seq
MIRT1265348	hsa-miR-524-5p	CLIP-seq
MIRT1265349	hsa-miR-623	CLIP-seq
MIRT2304512	hsa-miR-1224-3p	CLIP-seq
MIRT2304513	hsa-miR-1257	CLIP-seq
MIRT2304514	hsa-miR-1260	CLIP-seq
MIRT2304515	hsa-miR-1260b	CLIP-seq
MIRT1265326	hsa-miR-128	CLIP-seq
MIRT2304516	hsa-miR-1280	CLIP-seq
MIRT1265328	hsa-miR-1976	CLIP-seq
MIRT1265330	hsa-miR-204	CLIP-seq
MIRT1265331	hsa-miR-211	CLIP-seq
MIRT2304517	hsa-miR-2115	CLIP-seq
MIRT1265332	hsa-miR-24	CLIP-seq
MIRT1265333	hsa-miR-27a	CLIP-seq
MIRT1265334	hsa-miR-27b	CLIP-seq
MIRT1265336	hsa-miR-3127-3p	CLIP-seq
MIRT2304518	hsa-miR-3154	CLIP-seq
MIRT2304519	hsa-miR-3679-3p	CLIP-seq
MIRT2304520	hsa-miR-3689d	CLIP-seq
MIRT2304521	hsa-miR-4277	CLIP-seq
MIRT1265337	hsa-miR-4284	CLIP-seq
MIRT2304522	hsa-miR-4462	CLIP-seq
MIRT2078020	hsa-miR-4641	CLIP-seq
MIRT2304523	hsa-miR-4645-3p	CLIP-seq
MIRT2078021	hsa-miR-4722-3p	CLIP-seq
MIRT1265343	hsa-miR-4755-5p	CLIP-seq
MIRT1265345	hsa-miR-4780	CLIP-seq
MIRT2304524	hsa-miR-490-5p	CLIP-seq
MIRT1265346	hsa-miR-513a-5p	CLIP-seq
MIRT2304525	hsa-miR-542-3p	CLIP-seq
MIRT2304526	hsa-miR-584	CLIP-seq
MIRT2304527	hsa-miR-602	CLIP-seq
MIRT1265349	hsa-miR-623	CLIP-seq
MIRT2304528	hsa-miR-876-3p	CLIP-seq

Show/Hide all(53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000077	Process	DNA damage checkpoint signaling	IMP	24332808
GO:0000209	Process	Protein polyubiquitination	IDA	11435423
GO:0000244	Process	Spliceosomal tri-snRNP complex assembly	IDA	20595234
GO:0000245	Process	Spliceosomal complex assembly	IMP	16332694
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	20176811
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	23742842
GO:0000974	Component	Prp19 complex	IBA
GO:0000974	Component	Prp19 complex	IDA	20176811
GO:0000974	Component	Prp19 complex	IEA
GO:0000974	Component	Prp19 complex	IPI	20176811
GO:0001833	Process	Inner cell mass cell proliferation	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	19188445, 19633697, 19641227, 20176811, 20467437, 20595234, 21536736, 22365833, 22569250, 22961380, 23022480, 28514442, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	11435423, 19188445
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005662	Component	DNA replication factor A complex	IDA	24332808
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11435423
GO:0005737	Component	Cytoplasm	IEA
GO:0005811	Component	Lipid droplet	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006303	Process	Double-strand break repair via nonhomologous end joining	IMP	18263876
GO:0006397	Process	MRNA processing	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008104	Process	Intracellular protein localization	IMP	18263876
GO:0008380	Process	RNA splicing	IEA
GO:0008610	Process	Lipid biosynthetic process	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IMP	17349974
GO:0016020	Component	Membrane	HDA	19946888
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016607	Component	Nuclear speck	IDA	16332694, 24332808
GO:0016740	Function	Transferase activity	IEA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IDA	11435423
GO:0035861	Component	Site of double-strand break	IDA	18263876
GO:0042802	Function	Identical protein binding	IPI	16332694
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	11435423
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IMP	20595234
GO:0070534	Process	Protein K63-linked ubiquitination	IMP	20595234, 24332808
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IBA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

MIM	HGNC	e!Ensembl
608330	17896	ENSG00000110107

Protein

UniProt ID

Q9UMS4

Protein name

Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)

Protein function

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:2

PDB

4LG8 , 5MQF , 5XJC , 5YZG , 5Z56 , 5Z57 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 7A5P , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0T , 8I0U , 8I0V , 8I0W , 8RO2 , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04564	U-box	2 → 57	U-box domain	Domain
PF08606	Prp19	67 → 134	Prp19/Pso4-like	Domain
PF00400	WD40	254 → 292	WD domain, G-beta repeat	Repeat
PF00400	WD40	296 → 329	WD domain, G-beta repeat	Repeat
PF00400	WD40	338 → 378	WD domain, G-beta repeat	Repeat
PF00400	WD40	382 → 420	WD domain, G-beta repeat	Repeat
PF00400	WD40	465 → 503	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed in tumor cell lines. {ECO:0000269|PubMed:10404385, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO

Sequence

MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHP
IRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARL
TKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKA
TVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTG
GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQ
VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP
DGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD
LRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTG
VAFGHHAKFIASTGMDRSLKFYSL

Sequence length

504

Interactions

View interactions

	KEGG		Reactome
	Spliceosome Ubiquitin mediated proteolysis		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway

PRPF19 (pre-mRNA processing factor 19)