Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27201
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 78
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR78
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p16.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007057	hsa-miR-30d-5p	Luciferase reporter assay	23085757
MIRT007058	hsa-miR-181a-5p	Luciferase reporter assay	23085757
MIRT007061	hsa-miR-199a-5p	Luciferase reporter assay	23085757
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1031789	hsa-miR-4274	CLIP-seq
MIRT1031790	hsa-miR-4279	CLIP-seq
MIRT1031791	hsa-miR-4704-3p	CLIP-seq
MIRT1031792	hsa-miR-486-5p	CLIP-seq
MIRT2006029	hsa-miR-3158-3p	CLIP-seq
MIRT2006030	hsa-miR-4530	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	17363172
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	26940976
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17363172
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
606921	4528	ENSG00000155269

Protein

UniProt ID

Q96P69

Protein name

G-protein coupled receptor 78

Protein function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	22 → 294	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney. {ECO:0000269|PubMed:17363172}.

Sequence

MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDM
PFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRP
RYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVG
FVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRAT
RKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRP
FRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQ
QTH

Sequence length

363

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	35301432
Carcinoma Non Small Cell Lung	Associate	35986740, 36239568
Hypoxia	Associate	35301432

GPR78 (G protein-coupled receptor 78)