Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	27201
Gene name	G protein-coupled receptor 78
Gene symbol	GPR78
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4p16.1
Summary	The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007057	hsa-miR-30d-5p	Luciferase reporter assay	23085757
MIRT007058	hsa-miR-181a-5p	Luciferase reporter assay	23085757
MIRT007061	hsa-miR-199a-5p	Luciferase reporter assay	23085757
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT640635	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT629466	hsa-miR-181d-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT618547	hsa-miR-8485	HITS-CLIP	23824327
MIRT618546	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT618545	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT618544	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT618543	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT618542	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT1031789	hsa-miR-4274	CLIP-seq
MIRT1031790	hsa-miR-4279	CLIP-seq
MIRT1031791	hsa-miR-4704-3p	CLIP-seq
MIRT1031792	hsa-miR-486-5p	CLIP-seq
MIRT2006029	hsa-miR-3158-3p	CLIP-seq
MIRT2006030	hsa-miR-4530	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	17363172
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	26940976
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17363172
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
606921	4528	ENSG00000155269

Q96P69

Protein name

G-protein coupled receptor 78

Protein function

Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	22 → 294	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney. {ECO:0000269|PubMed:17363172}.

Sequence

MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDM
PFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRP
RYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVG
FVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRAT
RKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRP
FRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQ
QTH

Sequence length

363

Interactions

View interactions

GPR78 (G protein-coupled receptor 78)