Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	27148
Gene name Gene Name - the full gene name approved by the HGNC.	Serine/threonine kinase 36
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STK36
Synonyms (NCBI Gene) Gene synonyms aliases	CILD46, FU
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q35
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022162	hsa-miR-124-3p	Microarray	18668037
MIRT614439	hsa-miR-8485	HITS-CLIP	23824327
MIRT614438	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614437	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT629817	hsa-miR-603	HITS-CLIP	23824327
MIRT614436	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614435	hsa-miR-3941	HITS-CLIP	23824327
MIRT614434	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT614439	hsa-miR-8485	HITS-CLIP	23824327
MIRT614438	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614437	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT614436	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614435	hsa-miR-3941	HITS-CLIP	23824327
MIRT614434	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT734321	hsa-miR-21-5p	Immunofluorescence, qRT-PCR, RNA-seq, Western blotting	31735554
MIRT734322	hsa-miR-146b-3p	Immunofluorescence, qRT-PCR, RNA-seq, Western blotting	31735554
MIRT734323	hsa-miR-5571-3p	Immunofluorescence, qRT-PCR, RNA-seq, Western blotting	31735554
MIRT734324	hsa-miR-6503-3p	Immunofluorescence, qRT-PCR, RNA-seq, Western blotting	31735554
MIRT614439	hsa-miR-8485	HITS-CLIP	23824327
MIRT614438	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614437	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT629817	hsa-miR-603	HITS-CLIP	23824327
MIRT614436	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614435	hsa-miR-3941	HITS-CLIP	23824327
MIRT614434	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT614439	hsa-miR-8485	HITS-CLIP	23824327
MIRT614438	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT614437	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT614436	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT614435	hsa-miR-3941	HITS-CLIP	23824327
MIRT614434	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT1397927	hsa-miR-124	CLIP-seq
MIRT1397928	hsa-miR-1343	CLIP-seq
MIRT1397929	hsa-miR-329	CLIP-seq
MIRT1397930	hsa-miR-3714	CLIP-seq
MIRT1397931	hsa-miR-3910	CLIP-seq
MIRT1397932	hsa-miR-4521	CLIP-seq
MIRT1397933	hsa-miR-4640-5p	CLIP-seq
MIRT1397934	hsa-miR-4726-5p	CLIP-seq
MIRT1397935	hsa-miR-506	CLIP-seq
MIRT2119282	hsa-miR-2117	CLIP-seq
MIRT2119283	hsa-miR-3163	CLIP-seq
MIRT2119284	hsa-miR-4264	CLIP-seq
MIRT2119285	hsa-miR-4273	CLIP-seq
MIRT2119286	hsa-miR-4677-5p	CLIP-seq
MIRT2119287	hsa-miR-4797-3p	CLIP-seq
MIRT2119288	hsa-miR-578	CLIP-seq
MIRT1397927	hsa-miR-124	CLIP-seq
MIRT2341457	hsa-miR-1297	CLIP-seq
MIRT1397928	hsa-miR-1343	CLIP-seq
MIRT2341458	hsa-miR-2355-3p	CLIP-seq
MIRT2341459	hsa-miR-26a	CLIP-seq
MIRT2341460	hsa-miR-26b	CLIP-seq
MIRT2341461	hsa-miR-3192	CLIP-seq
MIRT2341462	hsa-miR-4300	CLIP-seq
MIRT2341463	hsa-miR-4465	CLIP-seq
MIRT2341464	hsa-miR-4484	CLIP-seq
MIRT1397935	hsa-miR-506	CLIP-seq
MIRT2341465	hsa-miR-520d-5p	CLIP-seq
MIRT2341466	hsa-miR-524-5p	CLIP-seq
MIRT2341467	hsa-miR-548an	CLIP-seq
MIRT2341468	hsa-miR-676	CLIP-seq
MIRT2341469	hsa-miR-920	CLIP-seq
MIRT2395353	hsa-miR-581	CLIP-seq
MIRT2635416	hsa-miR-1208	CLIP-seq
MIRT1397927	hsa-miR-124	CLIP-seq
MIRT1397928	hsa-miR-1343	CLIP-seq
MIRT2635417	hsa-miR-28-5p	CLIP-seq
MIRT2635418	hsa-miR-3120-5p	CLIP-seq
MIRT2635419	hsa-miR-3139	CLIP-seq
MIRT2635420	hsa-miR-3155	CLIP-seq
MIRT2635421	hsa-miR-3155b	CLIP-seq
MIRT2635422	hsa-miR-370	CLIP-seq
MIRT1397930	hsa-miR-3714	CLIP-seq
MIRT1397931	hsa-miR-3910	CLIP-seq
MIRT2635423	hsa-miR-4438	CLIP-seq
MIRT1397932	hsa-miR-4521	CLIP-seq
MIRT1397933	hsa-miR-4640-5p	CLIP-seq
MIRT2635424	hsa-miR-4646-5p	CLIP-seq
MIRT2635425	hsa-miR-4699-5p	CLIP-seq
MIRT1397934	hsa-miR-4726-5p	CLIP-seq
MIRT2635426	hsa-miR-4731-5p	CLIP-seq
MIRT2635427	hsa-miR-4747-5p	CLIP-seq
MIRT2635428	hsa-miR-484	CLIP-seq
MIRT1397935	hsa-miR-506	CLIP-seq
MIRT2635429	hsa-miR-548ac	CLIP-seq
MIRT2635430	hsa-miR-548d-3p	CLIP-seq
MIRT2635431	hsa-miR-548z	CLIP-seq
MIRT2635432	hsa-miR-708	CLIP-seq
MIRT2635433	hsa-miR-760	CLIP-seq
MIRT2635416	hsa-miR-1208	CLIP-seq
MIRT1397927	hsa-miR-124	CLIP-seq
MIRT2692258	hsa-miR-1252	CLIP-seq
MIRT1397928	hsa-miR-1343	CLIP-seq
MIRT2635417	hsa-miR-28-5p	CLIP-seq
MIRT2692259	hsa-miR-3120-3p	CLIP-seq
MIRT2635418	hsa-miR-3120-5p	CLIP-seq
MIRT2635419	hsa-miR-3139	CLIP-seq
MIRT2635420	hsa-miR-3155	CLIP-seq
MIRT2635421	hsa-miR-3155b	CLIP-seq
MIRT2119283	hsa-miR-3163	CLIP-seq
MIRT2341461	hsa-miR-3192	CLIP-seq
MIRT2635422	hsa-miR-370	CLIP-seq
MIRT1397930	hsa-miR-3714	CLIP-seq
MIRT1397931	hsa-miR-3910	CLIP-seq
MIRT2692260	hsa-miR-3942-5p	CLIP-seq
MIRT2692261	hsa-miR-4282	CLIP-seq
MIRT2692262	hsa-miR-4314	CLIP-seq
MIRT2692263	hsa-miR-4434	CLIP-seq
MIRT2635423	hsa-miR-4438	CLIP-seq
MIRT2692264	hsa-miR-4516	CLIP-seq
MIRT1397932	hsa-miR-4521	CLIP-seq
MIRT1397933	hsa-miR-4640-5p	CLIP-seq
MIRT2635424	hsa-miR-4646-5p	CLIP-seq
MIRT2692265	hsa-miR-4699-3p	CLIP-seq
MIRT2635425	hsa-miR-4699-5p	CLIP-seq
MIRT2692266	hsa-miR-4703-5p	CLIP-seq
MIRT1397934	hsa-miR-4726-5p	CLIP-seq
MIRT2635426	hsa-miR-4731-5p	CLIP-seq
MIRT2635427	hsa-miR-4747-5p	CLIP-seq
MIRT2692267	hsa-miR-4793-5p	CLIP-seq
MIRT2635428	hsa-miR-484	CLIP-seq
MIRT1397935	hsa-miR-506	CLIP-seq
MIRT2635429	hsa-miR-548ac	CLIP-seq
MIRT2635430	hsa-miR-548d-3p	CLIP-seq
MIRT2635431	hsa-miR-548z	CLIP-seq
MIRT2692268	hsa-miR-563	CLIP-seq
MIRT2692269	hsa-miR-570	CLIP-seq
MIRT2635432	hsa-miR-708	CLIP-seq
MIRT2635433	hsa-miR-760	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001222	Function	Transcription corepressor binding	IDA	10806483
GO:0003351	Process	Epithelial cilium movement involved in extracellular fluid movement	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	31279575
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	10806483
GO:0005515	Function	Protein binding	IPI	10806483, 25241761, 32707033, 32814053, 37584603
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	TAS	10806483
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IDA	10806483
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10806483
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	TAS	10806483
GO:0007017	Process	Microtubule-based process	IEA
GO:0007224	Process	Smoothened signaling pathway	IBA
GO:0007224	Process	Smoothened signaling pathway	IEA
GO:0007224	Process	Smoothened signaling pathway	IMP	31279575
GO:0007224	Process	Smoothened signaling pathway	ISS
GO:0007420	Process	Brain development	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0009791	Process	Post-embryonic development	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0035082	Process	Axoneme assembly	IMP	28543983
GO:0042995	Component	Cell projection	IEA
GO:0045880	Process	Positive regulation of smoothened signaling pathway	IEA
GO:0045880	Process	Positive regulation of smoothened signaling pathway	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051090	Process	Regulation of DNA-binding transcription factor activity	IDA	10806483
GO:0060271	Process	Cilium assembly	IEA
GO:0060271	Process	Cilium assembly	IMP	28543983
GO:0060271	Process	Cilium assembly	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
607652	17209	ENSG00000163482

Protein

UniProt ID

Q9NRP7

Protein name

Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)

Protein function

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and G

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	4 → 254	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells (PubMed:10806483). Expressed in respiratory epithelial cells of the lung (PubMed:28543983). {ECO:00002

Sequence

MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH
PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR
ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHT
ADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPR
QRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSR
ILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILAS
ELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEW
QHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLS
SLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFA
CTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGN
SRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISS
ALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYS
CCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGM
EKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRL
TPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEG
ELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLC
PSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQV
CCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSD
LLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHS
MALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQL
LGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSL
QQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM

Sequence length

1315

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	N/A	N/A	GWAS
Ciliary dyskinesia	Ciliary dyskinesia, primary, 46, ciliary dyskinesia, primary, 46, primary ciliary dyskinesia	N/A	N/A	ClinVar, GenCC

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Prostatic Neoplasms	Stimulate	38184689
Temple Baraitser Syndrome	Associate	27282200

STK36 (serine/threonine kinase 36)