Gene Gene information from NCBI Gene database.
Entrez ID 27115
Gene name Phosphodiesterase 7B
Gene symbol PDE7B
Synonyms (NCBI Gene)
bA472E5.1
Chromosome 6
Chromosome location 6q23.3
Summary The 3`,5`-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3`,5`-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5`-monophosphates a
miRNA miRNA information provided by mirtarbase database.
537
miRTarBase ID miRNA Experiments Reference
MIRT672230 hsa-miR-6715a-3p HITS-CLIP 23824327
MIRT672229 hsa-miR-4717-3p HITS-CLIP 23824327
MIRT672228 hsa-miR-6715b-3p HITS-CLIP 23824327
MIRT672227 hsa-miR-607 HITS-CLIP 23824327
MIRT672226 hsa-miR-1305 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0004112 Function Cyclic-nucleotide phosphodiesterase activity IEA
GO:0004114 Function 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
GO:0004115 Function 3',5'-cyclic-AMP phosphodiesterase activity IBA
GO:0004115 Function 3',5'-cyclic-AMP phosphodiesterase activity IDA 10814504, 10872825
GO:0004115 Function 3',5'-cyclic-AMP phosphodiesterase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604645 8792 ENSG00000171408
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NP56
Protein name 3',5'-cyclic-AMP phosphodiesterase 7B (EC 3.1.4.53) (cAMP-specific phosphodiesterase 7B)
Protein function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00233 PDEase_I 172 406 Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain (PubMed:10814504). Also expressed in heart, liver, skeletal muscle and pancreas (PubMed:10814504). {ECO:0000269|PubMed:10814504}.
Sequence
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHL
AHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
Sequence length 450
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Purine metabolism
Metabolic pathways
Morphine addiction
  G alpha (s) signalling events
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920799 RCV000149261
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 30209363
Colorectal Neoplasms Associate 37632791
Diabetes Mellitus Type 2 Associate 24603685
Fibrous Dysplasia of Bone Associate 31999703
Leukemia Associate 31740742
Leukemia Lymphocytic Chronic B Cell Associate 19033455, 21796143
Leukemia Myeloid Acute Associate 31740742
Neoplasms Associate 30209363
Prostatic Neoplasms Associate 25979379
Triple Negative Breast Neoplasms Associate 30209363