PGBD3 (piggyBac transposable element derived 3)

Gene

• Entrez ID: 267004
• Gene name: PiggyBac transposable element derived 3
• Gene symbol: PGBD3
• Synonyms (NCBI Gene): -
• Chromosome: 10
• Chromosome location: 10q11.23
• Summary: This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Alternative spl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1227214	hsa-miR-129-5p	CLIP-seq
MIRT1227215	hsa-miR-221	CLIP-seq
MIRT1227216	hsa-miR-222	CLIP-seq
MIRT1227217	hsa-miR-3163	CLIP-seq
MIRT1227218	hsa-miR-4282	CLIP-seq
MIRT1227219	hsa-miR-4307	CLIP-seq
MIRT1227220	hsa-miR-4452	CLIP-seq
MIRT1227221	hsa-miR-450b-5p	CLIP-seq
MIRT1227222	hsa-miR-4704-5p	CLIP-seq
MIRT1227223	hsa-miR-4709-3p	CLIP-seq
MIRT1227224	hsa-miR-507	CLIP-seq
MIRT1227225	hsa-miR-548a-3p	CLIP-seq
MIRT1227226	hsa-miR-548aa	CLIP-seq
MIRT1227227	hsa-miR-548e	CLIP-seq
MIRT1227228	hsa-miR-548f	CLIP-seq
MIRT1227229	hsa-miR-548v	CLIP-seq
MIRT1227230	hsa-miR-557	CLIP-seq
MIRT1227231	hsa-miR-568	CLIP-seq
MIRT1227215	hsa-miR-221	CLIP-seq
MIRT1227216	hsa-miR-222	CLIP-seq
MIRT1227226	hsa-miR-548aa	CLIP-seq
MIRT1227229	hsa-miR-548v	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0043565	Function	Sequence-specific DNA binding	IBA
GO:0043565	Function	Sequence-specific DNA binding	IDA	22483866

Other IDs

• MIM: HGNC
• HGNC: 19400
• e!Ensembl: N/A

Protein

• UniProt ID: Q8N328
• Protein name: PiggyBac transposable element-derived protein 3
• Protein function: Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. {ECO:0000269|PubMed:2248
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13843	DDE_Tnp_1_7	141 → 499	Transposase IS4	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart and oocytes, but not in granulosa cells (at protein level). {ECO:0000269|PubMed:26218421}.
• Sequence:

  MPRTLSLHEITDLLETDDSIEASAIVIQPPENATAPVSDEESGDEEGGTINNLPGSLLHT
  AAYLIQDGSDAESDSDDPSYAPKDDSPDEVPSTFTVQQPPPSRRRKMTKILCKWKKADLT
  VQPVAGRVTAPPNDFFTVMRTPTEILELFLDDEVIELIVKYSNLYACSKGVHLGLTSSEF
  KCFLGIIFLSGYVSVPRRRMFWEQRTDVHNVLVSAAMRRDRFETIFSNLHVADNANLDPV
  DKFSKLRPLISKLNERCMKFVPNETYFSFDEFMVPYFGRHGCKQFIRGKPIRFGYKFWCG
  ATCLGYICWFQPYQGKNPNTKHEEYGVGASLVLQFSEALTEAHPGQYHFVFNNFFTSIAL
  LDKLSSMGHQATGTVRKDHIDRVPLESDVALKKKERGTFDYRIDGKGNIVCRWNDNSVVT
  VASSGAGIHPLCLVSRYSQKLKKKIQVQQPNMIKVYNQFMGGVDRADENIDKYRASIRGK
  KWYSSPLLFCFELVLQNAWQLHKTYDEKPVDFLEFRRRVVCHYLETHGHPPEPGQKGRPQ
  KRNIDSRYDGINHVIVKQGKQTRCAECHKNTTFRCEKCDVALHVKCSVEYHTE

• Sequence length: 593

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cerebrooculofacioskeletal syndrome 1	Uncertain significance	rs370101518	RCV001199238
PGBD3-related disorder	Likely benign	rs751839495, rs373174504, rs201468099	RCV003919625 RCV003907308 RCV003971697

Associations from Text Mining
Disease Name	Relationship Type	References
Cockayne Syndrome	Associate	22483866
Primary Ovarian Insufficiency	Associate	26218421
UV Sensitive Syndrome	Associate	22483866