Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
266727
Gene name Gene Name - the full gene name approved by the HGNC.
MAM domain containing glycosylphosphatidylinositol anchor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MDGA1
Synonyms (NCBI Gene) Gene synonyms aliases
GPIM, MAMDC3
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six I
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003161 hsa-miR-210-3p immunoprecipitaion, Microarray, qRT-PCR 19826008
MIRT677340 hsa-miR-8485 HITS-CLIP 23313552
MIRT623286 hsa-miR-6793-3p HITS-CLIP 23313552
MIRT687569 hsa-miR-1913 HITS-CLIP 23313552
MIRT687568 hsa-miR-324-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration ISS
GO:0003674 Function Molecular_function ND
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space HDA 22664934
GO:0005794 Component Golgi apparatus IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609626 19267 ENSG00000112139
Protein
UniProt ID Q8NFP4
Protein name MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3)
Protein function Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO
PDB 5V5V , 5V5W , 5XEQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13927 Ig_3 40 112 Domain
PF13927 Ig_3 131 217 Domain
PF13927 Ig_3 239 312 Domain
PF13927 Ig_3 335 418 Domain
PF13927 Ig_3 439 517 Domain
PF13927 Ig_3 538 619 Domain
PF00629 MAM 753 917 MAM domain, meprin/A5/mu Domain
Tissue specificity TISSUE SPECIFICITY: Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues.
Sequence
MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQC
LVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAEN
GVGVPAIK
SIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQ
DNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVS
VRNVCGIPDKAITFRLTNTTAPP
ALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQA
RDSGYYNCTATN
NVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVD
AVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMAS
FP
GAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDK
EAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTA
RYNGFNVRPREAQVQLNVQFPPE
VEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAEL
RLDAVTRDSSGSYECSVSN
DVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVL
QWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVR
LTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALT
QNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHM
YGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY
LGDIAIDDVTLKKGECP
RKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR
Sequence length 955
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21146959, 18384059
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Restless Legs Syndrome Restless Legs Syndrome GWAS