Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	26575
Gene name	Regulator of G protein signaling 17
Gene symbol	RGS17
Synonyms (NCBI Gene)	RGS-17RGSZ2hRGS17
Chromosome	6
Chromosome location	6q25.2
Summary	This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024057	hsa-miR-1-3p	Microarray	18668037
MIRT028374	hsa-miR-32-5p	Sequencing	20371350
MIRT671793	hsa-miR-562	HITS-CLIP	23824327
MIRT671792	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT671791	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT671790	hsa-miR-5697	HITS-CLIP	23824327
MIRT671789	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT671787	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT671788	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT671786	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671785	hsa-miR-1976	HITS-CLIP	23824327
MIRT671784	hsa-miR-1297	HITS-CLIP	23824327
MIRT671783	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT671782	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT671781	hsa-miR-4465	HITS-CLIP	23824327
MIRT671780	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT671779	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT671778	hsa-miR-4279	HITS-CLIP	23824327
MIRT540236	hsa-miR-498	HITS-CLIP	23824327
MIRT654270	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT654269	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654268	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT654267	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT654265	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654266	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654264	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT540253	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540252	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT540251	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT540250	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540249	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540248	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540247	hsa-miR-1304-3p	PAR-CLIP	21572407
MIRT540246	hsa-miR-6821-3p	PAR-CLIP	21572407
MIRT540245	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT540244	hsa-miR-6791-3p	PAR-CLIP	21572407
MIRT540243	hsa-miR-6829-3p	PAR-CLIP	21572407
MIRT540242	hsa-miR-23a-5p	PAR-CLIP	21572407
MIRT540241	hsa-miR-23b-5p	PAR-CLIP	21572407
MIRT540240	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540239	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540238	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT540237	hsa-miR-6836-3p	PAR-CLIP	21572407
MIRT540236	hsa-miR-498	PAR-CLIP	21572407
MIRT540253	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540252	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT540251	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT540250	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540249	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540248	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540247	hsa-miR-1304-3p	PAR-CLIP	21572407
MIRT540246	hsa-miR-6821-3p	PAR-CLIP	21572407
MIRT540245	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT540244	hsa-miR-6791-3p	PAR-CLIP	21572407
MIRT540243	hsa-miR-6829-3p	PAR-CLIP	21572407
MIRT540242	hsa-miR-23a-5p	PAR-CLIP	21572407
MIRT540241	hsa-miR-23b-5p	PAR-CLIP	21572407
MIRT540240	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540239	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540238	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT540237	hsa-miR-6836-3p	PAR-CLIP	21572407
MIRT540236	hsa-miR-498	PAR-CLIP	21572407
MIRT497496	hsa-miR-1264	PAR-CLIP	22291592
MIRT497495	hsa-miR-5007-5p	PAR-CLIP	22291592
MIRT497494	hsa-miR-3973	PAR-CLIP	22291592
MIRT497493	hsa-miR-520g-3p	PAR-CLIP	22291592
MIRT497492	hsa-miR-520h	PAR-CLIP	22291592
MIRT497491	hsa-miR-936	PAR-CLIP	22291592
MIRT497490	hsa-miR-199a-3p	PAR-CLIP	22291592
MIRT497489	hsa-miR-199b-3p	PAR-CLIP	22291592
MIRT497488	hsa-miR-3129-5p	PAR-CLIP	22291592
MIRT497487	hsa-miR-4635	PAR-CLIP	22291592
MIRT497486	hsa-miR-222-5p	PAR-CLIP	22291592
MIRT448550	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT448548	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT448549	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT448547	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT448550	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT448548	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT448549	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT448547	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT028374	hsa-miR-32-5p	Western blot	26185539
MIRT736970	hsa-miR-149-5p	Luciferase reporter assayWestern blottingqRT-PCR	33790651
MIRT671793	hsa-miR-562	HITS-CLIP	23824327
MIRT671792	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT671791	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT671790	hsa-miR-5697	HITS-CLIP	23824327
MIRT671789	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT671787	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT671788	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT671786	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671785	hsa-miR-1976	HITS-CLIP	23824327
MIRT671784	hsa-miR-1297	HITS-CLIP	23824327
MIRT671783	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT671782	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT671781	hsa-miR-4465	HITS-CLIP	23824327
MIRT671780	hsa-miR-513c-5p	HITS-CLIP	23824327
MIRT671779	hsa-miR-514b-5p	HITS-CLIP	23824327
MIRT671778	hsa-miR-4279	HITS-CLIP	23824327
MIRT540236	hsa-miR-498	HITS-CLIP	23824327
MIRT654270	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT654269	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654268	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT654267	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT654265	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT654266	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654264	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT540253	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540252	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT540251	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT540250	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540249	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540248	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540247	hsa-miR-1304-3p	PAR-CLIP	21572407
MIRT540246	hsa-miR-6821-3p	PAR-CLIP	21572407
MIRT540245	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT540244	hsa-miR-6791-3p	PAR-CLIP	21572407
MIRT540243	hsa-miR-6829-3p	PAR-CLIP	21572407
MIRT540242	hsa-miR-23a-5p	PAR-CLIP	21572407
MIRT540241	hsa-miR-23b-5p	PAR-CLIP	21572407
MIRT540240	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540239	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540238	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT540237	hsa-miR-6836-3p	PAR-CLIP	21572407
MIRT540236	hsa-miR-498	PAR-CLIP	21572407
MIRT540253	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540252	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT540251	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT540250	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540249	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540248	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540247	hsa-miR-1304-3p	PAR-CLIP	21572407
MIRT540246	hsa-miR-6821-3p	PAR-CLIP	21572407
MIRT540245	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT540244	hsa-miR-6791-3p	PAR-CLIP	21572407
MIRT540243	hsa-miR-6829-3p	PAR-CLIP	21572407
MIRT540242	hsa-miR-23a-5p	PAR-CLIP	21572407
MIRT540241	hsa-miR-23b-5p	PAR-CLIP	21572407
MIRT540240	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540239	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540238	hsa-miR-5001-3p	PAR-CLIP	21572407
MIRT540237	hsa-miR-6836-3p	PAR-CLIP	21572407
MIRT540236	hsa-miR-498	PAR-CLIP	21572407
MIRT497496	hsa-miR-1264	PAR-CLIP	22291592
MIRT497495	hsa-miR-5007-5p	PAR-CLIP	22291592
MIRT497494	hsa-miR-3973	PAR-CLIP	22291592
MIRT497493	hsa-miR-520g-3p	PAR-CLIP	22291592
MIRT497492	hsa-miR-520h	PAR-CLIP	22291592
MIRT497491	hsa-miR-936	PAR-CLIP	22291592
MIRT497490	hsa-miR-199a-3p	PAR-CLIP	22291592
MIRT497489	hsa-miR-199b-3p	PAR-CLIP	22291592
MIRT497488	hsa-miR-3129-5p	PAR-CLIP	22291592
MIRT497487	hsa-miR-4635	PAR-CLIP	22291592
MIRT497486	hsa-miR-222-5p	PAR-CLIP	22291592
MIRT448550	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT448548	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT448549	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT448547	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT448550	hsa-miR-551b-5p	PAR-CLIP	22100165
MIRT448548	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT448549	hsa-miR-4524a-3p	PAR-CLIP	22100165
MIRT448547	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT1304248	hsa-miR-128	CLIP-seq
MIRT1304249	hsa-miR-27a	CLIP-seq
MIRT1304250	hsa-miR-27b	CLIP-seq
MIRT1304251	hsa-miR-3915	CLIP-seq
MIRT1304252	hsa-miR-3928	CLIP-seq
MIRT1304253	hsa-miR-409-3p	CLIP-seq
MIRT1304254	hsa-miR-4293	CLIP-seq
MIRT1304255	hsa-miR-4694-3p	CLIP-seq
MIRT1304256	hsa-miR-5096	CLIP-seq
MIRT1304257	hsa-miR-513a-5p	CLIP-seq
MIRT1304258	hsa-miR-544b	CLIP-seq
MIRT1304259	hsa-miR-596	CLIP-seq
MIRT1304260	hsa-miR-653	CLIP-seq
MIRT2090176	hsa-miR-1271	CLIP-seq
MIRT2090177	hsa-miR-1290	CLIP-seq
MIRT2090178	hsa-miR-182	CLIP-seq
MIRT2090179	hsa-miR-4760-3p	CLIP-seq
MIRT2090180	hsa-miR-495	CLIP-seq
MIRT2090181	hsa-miR-664	CLIP-seq
MIRT2090182	hsa-miR-96	CLIP-seq
MIRT2314899	hsa-miR-3646	CLIP-seq
MIRT2314900	hsa-miR-515-5p	CLIP-seq
MIRT2393689	hsa-miR-4328	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001975	Process	Response to amphetamine	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA

MIM	HGNC	e!Ensembl
607191	14088	ENSG00000091844

Q9UGC6

Protein name

Regulator of G-protein signaling 17 (RGS17)

Protein function

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, ther

PDB

1ZV4 , 6AM3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	84 → 199	Regulator of G protein signaling domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. {ECO:0000269|PubMed:15096504}.

Sequence

MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGENAGRPTHTTK
MESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDL
KKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHMYEDAQLQIYT
LMHRDSFPRFLNSQIYKSFVESTAGSSSES

Sequence length

210

Interactions

View interactions

	Reactome
			G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events

RGS17 (regulator of G protein signaling 17)