Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	26286
Gene name	ARF GTPase activating protein 3
Gene symbol	ARFGAP3
Synonyms (NCBI Gene)	ARFGAP1
Chromosome	22
Chromosome location	22q13.2
Summary	The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, wh

Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038823	hsa-miR-93-3p	CLASH	23622248
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT792887	hsa-miR-4789-5p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT792892	hsa-miR-626	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792896	hsa-miR-944	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT792900	hsa-miR-3659	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792901	hsa-miR-4658	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792902	hsa-miR-544	CLIP-seq
MIRT792903	hsa-miR-574-5p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT1933981	hsa-miR-515-5p	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT2173807	hsa-miR-3120-3p	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT2173808	hsa-miR-4420	CLIP-seq
MIRT2173809	hsa-miR-4457	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2173811	hsa-miR-494	CLIP-seq
MIRT2173812	hsa-miR-513b	CLIP-seq
MIRT2384359	hsa-miR-1252	CLIP-seq
MIRT2384360	hsa-miR-147	CLIP-seq
MIRT2384361	hsa-miR-3911	CLIP-seq
MIRT2384362	hsa-miR-595	CLIP-seq
MIRT2384363	hsa-miR-644	CLIP-seq
MIRT2443854	hsa-miR-4433	CLIP-seq
MIRT2443855	hsa-miR-4459	CLIP-seq
MIRT2443856	hsa-miR-4537	CLIP-seq
MIRT2443857	hsa-miR-4722-5p	CLIP-seq
MIRT2443858	hsa-miR-4768-3p	CLIP-seq
MIRT2443859	hsa-miR-765	CLIP-seq
MIRT2477507	hsa-miR-1245b-3p	CLIP-seq
MIRT2477508	hsa-miR-139-3p	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477510	hsa-miR-3173-3p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT2477511	hsa-miR-3671	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477513	hsa-miR-4455	CLIP-seq
MIRT2477514	hsa-miR-4779	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq
MIRT2477518	hsa-miR-607	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT2477519	hsa-miR-656	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	11172815
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	23275563, 24705354, 32296183, 32814053, 35156780, 36012204
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA	11172815
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	NAS	11172815
GO:0008270	Function	Zinc ion binding	IEA
GO:0009306	Process	Protein secretion	IEP	11172815
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016192	Process	Vesicle-mediated transport	NAS	11172815
GO:0046872	Function	Metal ion binding	IEA
GO:0048205	Process	COPI coating of Golgi vesicle	IBA

MIM	HGNC	e!Ensembl
612439	661	ENSG00000242247

Q9NP61

Protein name

ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)

Protein function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

PDB

2CRW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	10 → 124	Putative GTPase activating protein for Arf	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. {ECO:0000269|PubMed:10704287}.

Sequence

MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
FIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSL
ASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPV
ETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANT
CFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNV
DSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEP
VELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKK
FGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLP
NAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS

Sequence length

516

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

ARFGAP3 (ARF GTPase activating protein 3)