Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26286
Gene name Gene Name - the full gene name approved by the HGNC.	ARF GTPase activating protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARFGAP3
Synonyms (NCBI Gene) Gene synonyms aliases	ARFGAP1
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, wh

Show/Hide all(86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038823	hsa-miR-93-3p	CLASH	23622248
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT792887	hsa-miR-4789-5p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT792892	hsa-miR-626	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792896	hsa-miR-944	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT792900	hsa-miR-3659	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792901	hsa-miR-4658	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792902	hsa-miR-544	CLIP-seq
MIRT792903	hsa-miR-574-5p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT1933981	hsa-miR-515-5p	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT2173807	hsa-miR-3120-3p	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT2173808	hsa-miR-4420	CLIP-seq
MIRT2173809	hsa-miR-4457	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2173811	hsa-miR-494	CLIP-seq
MIRT2173812	hsa-miR-513b	CLIP-seq
MIRT2384359	hsa-miR-1252	CLIP-seq
MIRT2384360	hsa-miR-147	CLIP-seq
MIRT2384361	hsa-miR-3911	CLIP-seq
MIRT2384362	hsa-miR-595	CLIP-seq
MIRT2384363	hsa-miR-644	CLIP-seq
MIRT2443854	hsa-miR-4433	CLIP-seq
MIRT2443855	hsa-miR-4459	CLIP-seq
MIRT2443856	hsa-miR-4537	CLIP-seq
MIRT2443857	hsa-miR-4722-5p	CLIP-seq
MIRT2443858	hsa-miR-4768-3p	CLIP-seq
MIRT2443859	hsa-miR-765	CLIP-seq
MIRT2477507	hsa-miR-1245b-3p	CLIP-seq
MIRT2477508	hsa-miR-139-3p	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477510	hsa-miR-3173-3p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT2477511	hsa-miR-3671	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477513	hsa-miR-4455	CLIP-seq
MIRT2477514	hsa-miR-4779	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq
MIRT2477518	hsa-miR-607	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT2477519	hsa-miR-656	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	11172815
GO:0005515	Function	Protein binding	IPI	23275563, 24705354, 32296183, 32814053
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA	11172815
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	NAS	11172815
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0009306	Process	Protein secretion	IEP	11172815
GO:0016020	Component	Membrane	HDA	19946888
GO:0016192	Process	Vesicle-mediated transport	NAS	11172815
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048205	Process	COPI coating of Golgi vesicle	IBA	21873635

MIM	HGNC	e!Ensembl
612439	661	ENSG00000242247

Protein

UniProt ID

Q9NP61

Protein name

ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)

Protein function

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

PDB

2CRW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	10 → 124	Putative GTPase activating protein for Arf	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary. {ECO:0000269|PubMed:10704287}.

Sequence

MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
FIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSL
ASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPV
ETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANT
CFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNV
DSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEP
VELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKK
FGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLP
NAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS

Sequence length

516

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Neoplasms Squamous Cell	Associate	30589052
Obesity	Associate	31880793
Oculocutaneous albinism type 2	Inhibit	31868832
Pelvic Organ Prolapse	Inhibit	31868832

ARFGAP3 (ARF GTPase activating protein 3)