Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	26260
Gene name	F-box protein 25
Gene symbol	FBXO25
Synonyms (NCBI Gene)	FBX25
Chromosome	8
Chromosome location	8p23.3
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024524	hsa-miR-215-5p	Microarray	19074876
MIRT026896	hsa-miR-192-5p	Microarray	19074876
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT685428	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT685427	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT685426	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT649088	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT649086	hsa-miR-6723-5p	HITS-CLIP	23824327
MIRT649085	hsa-miR-4540	HITS-CLIP	23824327
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT649088	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT649087	hsa-miR-4656	HITS-CLIP	23824327
MIRT649086	hsa-miR-6723-5p	HITS-CLIP	23824327
MIRT649085	hsa-miR-4540	HITS-CLIP	23824327
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT685428	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT685427	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT685426	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT649088	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT649086	hsa-miR-6723-5p	HITS-CLIP	23824327
MIRT649085	hsa-miR-4540	HITS-CLIP	23824327
MIRT649089	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT649088	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT649087	hsa-miR-4656	HITS-CLIP	23824327
MIRT649086	hsa-miR-6723-5p	HITS-CLIP	23824327
MIRT649085	hsa-miR-4540	HITS-CLIP	23824327
MIRT991563	hsa-miR-1287	CLIP-seq
MIRT991564	hsa-miR-1914	CLIP-seq
MIRT991565	hsa-miR-1915	CLIP-seq
MIRT991566	hsa-miR-3135b	CLIP-seq
MIRT991567	hsa-miR-3154	CLIP-seq
MIRT991568	hsa-miR-3160-5p	CLIP-seq
MIRT991569	hsa-miR-3189-3p	CLIP-seq
MIRT991570	hsa-miR-345	CLIP-seq
MIRT991571	hsa-miR-3647-3p	CLIP-seq
MIRT991572	hsa-miR-4276	CLIP-seq
MIRT991573	hsa-miR-4277	CLIP-seq
MIRT991574	hsa-miR-4436b-3p	CLIP-seq
MIRT991575	hsa-miR-4722-3p	CLIP-seq
MIRT991576	hsa-miR-4726-3p	CLIP-seq
MIRT991577	hsa-miR-4757-5p	CLIP-seq
MIRT991578	hsa-miR-502-5p	CLIP-seq
MIRT991579	hsa-miR-649	CLIP-seq
MIRT991565	hsa-miR-1915	CLIP-seq
MIRT1994075	hsa-miR-23a	CLIP-seq
MIRT1994076	hsa-miR-23b	CLIP-seq
MIRT1994077	hsa-miR-23c	CLIP-seq
MIRT991567	hsa-miR-3154	CLIP-seq
MIRT991568	hsa-miR-3160-5p	CLIP-seq
MIRT1994078	hsa-miR-3976	CLIP-seq
MIRT1994079	hsa-miR-4272	CLIP-seq
MIRT991572	hsa-miR-4276	CLIP-seq
MIRT991573	hsa-miR-4277	CLIP-seq
MIRT1994080	hsa-miR-4282	CLIP-seq
MIRT991574	hsa-miR-4436b-3p	CLIP-seq
MIRT991576	hsa-miR-4726-3p	CLIP-seq
MIRT1994081	hsa-miR-513a-3p	CLIP-seq
MIRT1994075	hsa-miR-23a	CLIP-seq
MIRT1994076	hsa-miR-23b	CLIP-seq
MIRT1994077	hsa-miR-23c	CLIP-seq
MIRT1994080	hsa-miR-4282	CLIP-seq
MIRT2228059	hsa-miR-4517	CLIP-seq
MIRT1994081	hsa-miR-513a-3p	CLIP-seq
MIRT2228060	hsa-miR-889	CLIP-seq
MIRT2531621	hsa-miR-214	CLIP-seq
MIRT2531622	hsa-miR-3619-5p	CLIP-seq
MIRT2531623	hsa-miR-761	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	NAS	10531035
GO:0003779	Function	Actin binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	NAS	10531035
GO:0005515	Function	Protein binding	IPI	20473970, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16278047
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005730	Component	Nucleolus	IDA	16278047
GO:0005737	Component	Cytoplasm	IBA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	ISS
GO:0016567	Process	Protein ubiquitination	NAS	10531035
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019005	Component	SCF ubiquitin ligase complex	ISS

MIM	HGNC	e!Ensembl
609098	13596	ENSG00000147364

Q8TCJ0

Protein name

F-box only protein 25

Protein function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in all brain tissue observed. {ECO:0000269|PubMed:16278047}.

Sequence

MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNRCNISHSIILNSEDGEIFNNEEH
EYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIR
RFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHHNPRLIKDLLQDLSSTL
CILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNIL
YRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMY
FALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPDSCFTPVSPQH
FIDLFKF

Sequence length

367

Interactions

View interactions

	KEGG
	FoxO signaling pathway

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hepatocellular carcinoma	Uncertain significance	rs558624439	RCV005932640

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	27596142
Carcinoma Non Small Cell Lung	Associate	27596142
Epilepsy	Associate	33925474
Gastrointestinal Stromal Tumors	Associate	25987131
Lung Neoplasms	Associate	27596142
Lymphatic Metastasis	Stimulate	27596142
Neoplasms	Associate	27556634, 40117808
Ovarian Neoplasms	Associate	40117808

FBXO25 (F-box protein 25)