Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	26253
Gene name Gene Name - the full gene name approved by the HGNC.	C-type lectin domain family 4 member E
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLEC4E
Synonyms (NCBI Gene) Gene synonyms aliases	CLECSF9, MINCLE
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles

Show/Hide all(201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT518202	hsa-miR-5692a	PAR-CLIP	23446348
MIRT518201	hsa-miR-3529-3p	PAR-CLIP	23446348
MIRT518200	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT518199	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT518198	hsa-miR-6742-3p	PAR-CLIP	23446348
MIRT518196	hsa-miR-378g	PAR-CLIP	23446348
MIRT518197	hsa-miR-6776-5p	PAR-CLIP	23446348
MIRT518195	hsa-miR-27a-5p	PAR-CLIP	23446348
MIRT518194	hsa-miR-374c-5p	PAR-CLIP	23446348
MIRT518193	hsa-miR-655-3p	PAR-CLIP	23446348
MIRT518192	hsa-miR-1262	PAR-CLIP	23446348
MIRT518191	hsa-miR-4701-3p	PAR-CLIP	23446348
MIRT518189	hsa-miR-6736-5p	PAR-CLIP	23446348
MIRT518190	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT518202	hsa-miR-5692a	PAR-CLIP	23446348
MIRT518201	hsa-miR-3529-3p	PAR-CLIP	23446348
MIRT518200	hsa-miR-619-3p	PAR-CLIP	23446348
MIRT518199	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT518198	hsa-miR-6742-3p	PAR-CLIP	23446348
MIRT518196	hsa-miR-378g	PAR-CLIP	23446348
MIRT518197	hsa-miR-6776-5p	PAR-CLIP	23446348
MIRT518195	hsa-miR-27a-5p	PAR-CLIP	23446348
MIRT518194	hsa-miR-374c-5p	PAR-CLIP	23446348
MIRT518193	hsa-miR-655-3p	PAR-CLIP	23446348
MIRT518192	hsa-miR-1262	PAR-CLIP	23446348
MIRT518191	hsa-miR-4701-3p	PAR-CLIP	23446348
MIRT518189	hsa-miR-6736-5p	PAR-CLIP	23446348
MIRT518190	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT896054	hsa-miR-103a	CLIP-seq
MIRT896055	hsa-miR-107	CLIP-seq
MIRT896056	hsa-miR-1206	CLIP-seq
MIRT896057	hsa-miR-1270	CLIP-seq
MIRT896058	hsa-miR-1276	CLIP-seq
MIRT896059	hsa-miR-1289	CLIP-seq
MIRT896060	hsa-miR-1301	CLIP-seq
MIRT896061	hsa-miR-143	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT896065	hsa-miR-3141	CLIP-seq
MIRT896066	hsa-miR-3154	CLIP-seq
MIRT896067	hsa-miR-3160-3p	CLIP-seq
MIRT896068	hsa-miR-3198	CLIP-seq
MIRT896069	hsa-miR-338-5p	CLIP-seq
MIRT896070	hsa-miR-3616-3p	CLIP-seq
MIRT896071	hsa-miR-3622a-5p	CLIP-seq
MIRT896072	hsa-miR-3622b-5p	CLIP-seq
MIRT896073	hsa-miR-3652	CLIP-seq
MIRT896074	hsa-miR-374c	CLIP-seq
MIRT896075	hsa-miR-3909	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT896077	hsa-miR-4294	CLIP-seq
MIRT896078	hsa-miR-4309	CLIP-seq
MIRT896079	hsa-miR-4311	CLIP-seq
MIRT896080	hsa-miR-4317	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT896082	hsa-miR-4423-3p	CLIP-seq
MIRT896083	hsa-miR-4430	CLIP-seq
MIRT896084	hsa-miR-4505	CLIP-seq
MIRT896085	hsa-miR-4633-3p	CLIP-seq
MIRT896086	hsa-miR-4643	CLIP-seq
MIRT896087	hsa-miR-4683	CLIP-seq
MIRT896088	hsa-miR-4720-5p	CLIP-seq
MIRT896089	hsa-miR-4721	CLIP-seq
MIRT896090	hsa-miR-4770	CLIP-seq
MIRT896091	hsa-miR-4790-5p	CLIP-seq
MIRT896092	hsa-miR-4799-3p	CLIP-seq
MIRT896093	hsa-miR-5047	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT896096	hsa-miR-513b	CLIP-seq
MIRT896097	hsa-miR-548p	CLIP-seq
MIRT896098	hsa-miR-548u	CLIP-seq
MIRT896099	hsa-miR-583	CLIP-seq
MIRT896100	hsa-miR-619	CLIP-seq
MIRT896101	hsa-miR-620	CLIP-seq
MIRT896102	hsa-miR-642b	CLIP-seq
MIRT896103	hsa-miR-655	CLIP-seq
MIRT896104	hsa-miR-934	CLIP-seq
MIRT896054	hsa-miR-103a	CLIP-seq
MIRT896055	hsa-miR-107	CLIP-seq
MIRT896056	hsa-miR-1206	CLIP-seq
MIRT896060	hsa-miR-1301	CLIP-seq
MIRT1965655	hsa-miR-196a	CLIP-seq
MIRT1965656	hsa-miR-196b	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT1965657	hsa-miR-219-2-3p	CLIP-seq
MIRT1965658	hsa-miR-2964a-3p	CLIP-seq
MIRT1965659	hsa-miR-302f	CLIP-seq
MIRT1965660	hsa-miR-3606	CLIP-seq
MIRT1965661	hsa-miR-3646	CLIP-seq
MIRT896075	hsa-miR-3909	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT1965662	hsa-miR-4300	CLIP-seq
MIRT896080	hsa-miR-4317	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT1965663	hsa-miR-4528	CLIP-seq
MIRT896085	hsa-miR-4633-3p	CLIP-seq
MIRT896086	hsa-miR-4643	CLIP-seq
MIRT1965664	hsa-miR-4789-5p	CLIP-seq
MIRT896093	hsa-miR-5047	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT896096	hsa-miR-513b	CLIP-seq
MIRT896098	hsa-miR-548u	CLIP-seq
MIRT1965665	hsa-miR-550b	CLIP-seq
MIRT1965666	hsa-miR-610	CLIP-seq
MIRT896100	hsa-miR-619	CLIP-seq
MIRT896102	hsa-miR-642b	CLIP-seq
MIRT1965667	hsa-miR-920	CLIP-seq
MIRT896054	hsa-miR-103a	CLIP-seq
MIRT896055	hsa-miR-107	CLIP-seq
MIRT896056	hsa-miR-1206	CLIP-seq
MIRT2201603	hsa-miR-1272	CLIP-seq
MIRT896060	hsa-miR-1301	CLIP-seq
MIRT1965655	hsa-miR-196a	CLIP-seq
MIRT1965656	hsa-miR-196b	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT1965657	hsa-miR-219-2-3p	CLIP-seq
MIRT1965658	hsa-miR-2964a-3p	CLIP-seq
MIRT1965659	hsa-miR-302f	CLIP-seq
MIRT2201604	hsa-miR-3065-5p	CLIP-seq
MIRT2201605	hsa-miR-3163	CLIP-seq
MIRT1965660	hsa-miR-3606	CLIP-seq
MIRT1965661	hsa-miR-3646	CLIP-seq
MIRT896075	hsa-miR-3909	CLIP-seq
MIRT2201606	hsa-miR-410	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT1965662	hsa-miR-4300	CLIP-seq
MIRT896080	hsa-miR-4317	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT896085	hsa-miR-4633-3p	CLIP-seq
MIRT896086	hsa-miR-4643	CLIP-seq
MIRT2201607	hsa-miR-4802-3p	CLIP-seq
MIRT2201608	hsa-miR-495	CLIP-seq
MIRT896093	hsa-miR-5047	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT896096	hsa-miR-513b	CLIP-seq
MIRT2201609	hsa-miR-548aa	CLIP-seq
MIRT896097	hsa-miR-548p	CLIP-seq
MIRT896098	hsa-miR-548u	CLIP-seq
MIRT1965666	hsa-miR-610	CLIP-seq
MIRT896102	hsa-miR-642b	CLIP-seq
MIRT1965667	hsa-miR-920	CLIP-seq
MIRT896054	hsa-miR-103a	CLIP-seq
MIRT896055	hsa-miR-107	CLIP-seq
MIRT896056	hsa-miR-1206	CLIP-seq
MIRT2386171	hsa-miR-1292	CLIP-seq
MIRT896060	hsa-miR-1301	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT896075	hsa-miR-3909	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT896080	hsa-miR-4317	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT2386172	hsa-miR-4471	CLIP-seq
MIRT896093	hsa-miR-5047	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT896096	hsa-miR-513b	CLIP-seq
MIRT896097	hsa-miR-548p	CLIP-seq
MIRT2386171	hsa-miR-1292	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT2386172	hsa-miR-4471	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT2201609	hsa-miR-548aa	CLIP-seq
MIRT2386171	hsa-miR-1292	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT2386172	hsa-miR-4471	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT2201609	hsa-miR-548aa	CLIP-seq
MIRT2386171	hsa-miR-1292	CLIP-seq
MIRT896062	hsa-miR-200b	CLIP-seq
MIRT896063	hsa-miR-200c	CLIP-seq
MIRT896064	hsa-miR-217	CLIP-seq
MIRT2201604	hsa-miR-3065-5p	CLIP-seq
MIRT2201605	hsa-miR-3163	CLIP-seq
MIRT2201606	hsa-miR-410	CLIP-seq
MIRT896076	hsa-miR-429	CLIP-seq
MIRT896081	hsa-miR-4418	CLIP-seq
MIRT2386172	hsa-miR-4471	CLIP-seq
MIRT2201608	hsa-miR-495	CLIP-seq
MIRT896094	hsa-miR-509-3-5p	CLIP-seq
MIRT896095	hsa-miR-509-5p	CLIP-seq
MIRT2201609	hsa-miR-548aa	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002221	Process	Pattern recognition receptor signaling pathway	IMP	24101491
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0005509	Function	Calcium ion binding	IDA	24101491
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IDA	24101491
GO:0016021	Component	Integral component of membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0038187	Function	Pattern recognition receptor activity	IDA	24101491
GO:0045087	Process	Innate immune response	IEA

MIM	HGNC	e!Ensembl
609962	14555	ENSG00000166523

Protein

UniProt ID

Q9ULY5

Protein name

C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE)

Protein function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and f

PDB

3WH2 , 3WH3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	97 → 207	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in monocytes and macrophages. {ECO:0000269|PubMed:23602766}.

Sequence

MNSSKSSETQCTERGCFSSQMFLWTVAGIPILFLSACFITRCVVTFRIFQTCDEKKFQLP
ENFTELSCYNYGSGSVKNCCPLNWEYFQSSCYFFSTDTISWALSLKNCSAMGAHLVVINS
QEEQEFLSYKKPKMREFFIGLSDQVVEGQWQWVDGTPLTKSLSFWDVGEPNNIATLEDCA
TMRDSSNPRQNWNDVTCFLNYFRICEMVGINPLNKGKSL

Sequence length

219

Interactions

View interactions

	KEGG		Reactome
	C-type lectin receptor signaling pathway Tuberculosis		Dectin-2 family

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Takayasu Arteritis	Takayasu Arteritis			GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Rheumatoid	Associate	17082220
Diabetic Nephropathies	Associate	36329882
Myocardial Infarction	Associate	31863085
ST Elevation Myocardial Infarction	Associate	31863085
Tuberculosis Pulmonary	Associate	32971250
Urinary Bladder Neoplasms	Associate	36131933

CLEC4E (C-type lectin domain family 4 member E)