TTLL3 (tubulin tyrosine ligase like 3)

Gene

• Entrez ID: 26140
• Gene name: Tubulin tyrosine ligase like 3
• Gene symbol: TTLL3
• Synonyms (NCBI Gene): HOTTL
• Chromosome: 3
• Chromosome location: 3p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022524	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT1462396	hsa-miR-1912	CLIP-seq
MIRT1462397	hsa-miR-3130-5p	CLIP-seq
MIRT1462398	hsa-miR-3607-3p	CLIP-seq
MIRT1462399	hsa-miR-3686	CLIP-seq
MIRT1462400	hsa-miR-3934	CLIP-seq
MIRT1462401	hsa-miR-3942-3p	CLIP-seq
MIRT1462402	hsa-miR-4328	CLIP-seq
MIRT1462403	hsa-miR-4482	CLIP-seq
MIRT1462404	hsa-miR-4494	CLIP-seq
MIRT1462405	hsa-miR-4659a-3p	CLIP-seq
MIRT1462406	hsa-miR-4659b-3p	CLIP-seq
MIRT1462407	hsa-miR-499a-5p	CLIP-seq
MIRT1462408	hsa-miR-552	CLIP-seq
MIRT1462400	hsa-miR-3934	CLIP-seq
MIRT2139081	hsa-miR-4740-3p	CLIP-seq
MIRT1462408	hsa-miR-552	CLIP-seq
MIRT2359801	hsa-miR-1283	CLIP-seq
MIRT1462396	hsa-miR-1912	CLIP-seq
MIRT2359802	hsa-miR-1915	CLIP-seq
MIRT2359803	hsa-miR-24	CLIP-seq
MIRT1462397	hsa-miR-3130-5p	CLIP-seq
MIRT2359804	hsa-miR-3155	CLIP-seq
MIRT2359805	hsa-miR-3155b	CLIP-seq
MIRT1462400	hsa-miR-3934	CLIP-seq
MIRT2359806	hsa-miR-4432	CLIP-seq
MIRT1462403	hsa-miR-4482	CLIP-seq
MIRT2359807	hsa-miR-4726-3p	CLIP-seq
MIRT2359808	hsa-miR-484	CLIP-seq
MIRT2359809	hsa-miR-500a	CLIP-seq
MIRT2359810	hsa-miR-520d-5p	CLIP-seq
MIRT2359811	hsa-miR-524-5p	CLIP-seq
MIRT2359812	hsa-miR-548u	CLIP-seq
MIRT1462408	hsa-miR-552	CLIP-seq
MIRT1462398	hsa-miR-3607-3p	CLIP-seq
MIRT1462399	hsa-miR-3686	CLIP-seq
MIRT1462402	hsa-miR-4328	CLIP-seq
MIRT1462404	hsa-miR-4494	CLIP-seq
MIRT1462405	hsa-miR-4659a-3p	CLIP-seq
MIRT1462406	hsa-miR-4659b-3p	CLIP-seq
MIRT1462407	hsa-miR-499a-5p	CLIP-seq
MIRT2694461	hsa-miR-1227	CLIP-seq
MIRT2694462	hsa-miR-3117-3p	CLIP-seq
MIRT2694463	hsa-miR-3169	CLIP-seq
MIRT2694464	hsa-miR-3650	CLIP-seq
MIRT1462400	hsa-miR-3934	CLIP-seq
MIRT2694465	hsa-miR-4715-3p	CLIP-seq
MIRT2694466	hsa-miR-4735-5p	CLIP-seq
MIRT2694467	hsa-miR-4759	CLIP-seq
MIRT2694468	hsa-miR-4775	CLIP-seq
MIRT1462408	hsa-miR-552	CLIP-seq
MIRT2694469	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	ISS
GO:0005930	Component	Axoneme	ISS
GO:0015630	Component	Microtubule cytoskeleton	ISS
GO:0018094	Process	Protein polyglycylation	IDA	19524510
GO:0018094	Process	Protein polyglycylation	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0035082	Process	Axoneme assembly	ISS
GO:0060271	Process	Cilium assembly	ISS
GO:0070735	Function	Protein-glycine ligase activity	IDA	19524510
GO:0070736	Function	Protein-glycine ligase activity, initiating	ISS

Other IDs

• MIM: 619195
• HGNC: 24483
• e!Ensembl: ENSG00000214021

Protein

• UniProt ID: Q9Y4R7
• Protein name: Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3)
• Protein function: Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	213 → 505	Tubulin-tyrosine ligase family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, heart, kidney, testis, liver, lung, muscle, spleen, trachea and colon. {ECO:0000269|PubMed:25180231}.
• Sequence:

  MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLD
  SSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDE
  VDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQ
  PKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQRYYQV
  VHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLE
  EMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIR
  FSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAW
  STIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPST
  AVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKK
  PMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLV
  GTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLC
  PLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKL
  GKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGSTARA

• Sequence length: 772

Pathways

Reactome:

Carboxyterminal post-translational modifications of tubulin

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease term	Disease name	Evidence	References	Source
Alzheimer disease	Alzheimer disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Persistent Fetal Circulation Syndrome	Associate	32054482