Gene Gene information from NCBI Gene database.
Entrez ID 26136
Gene name Testin LIM domain protein
Gene symbol TES
Synonyms (NCBI Gene)
TESSTESS-2
Chromosome 7
Chromosome location 7q31.2
Summary Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli ce
miRNA miRNA information provided by mirtarbase database.
443
miRTarBase ID miRNA Experiments Reference
MIRT019575 hsa-miR-340-5p Sequencing 20371350
MIRT020280 hsa-miR-130b-3p Sequencing 20371350
MIRT021189 hsa-miR-186-5p Sequencing 20371350
MIRT025480 hsa-miR-34a-5p Proteomics 21566225
MIRT027620 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 21278383, 32814053
GO:0005634 Component Nucleus HDA 21630459
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606085 14620 ENSG00000135269
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UGI8
Protein name Testin (TESS)
Protein function Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:000
PDB 2IYB , 2XQN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06297 PET 109 193 PET Domain Domain
PF00412 LIM 236 297 LIM domain Domain
PF00412 LIM 301 357 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11420696}.
Sequence
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED
RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ
ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK
KYKSEALGVGDVK
LPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK
LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE
KPR
CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV
CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM
S
Sequence length 421
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLITIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLAUCOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Astrocytoma Associate 24650279
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Inhibit 12695497
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 25119600, 25809865
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 36530957
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 25498217
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hypoxia Associate 35789607
★☆☆☆☆
Found in Text Mining only
Immunologic Deficiency Syndromes Associate 39925840
★☆☆☆☆
Found in Text Mining only
Leukemia T Cell Inhibit 26985820
★☆☆☆☆
Found in Text Mining only
Lymphatic Metastasis Associate 25119600
★☆☆☆☆
Found in Text Mining only
Melanoma Associate 22201996
★☆☆☆☆
Found in Text Mining only