Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
26136
Gene name Gene Name - the full gene name approved by the HGNC.
Testin LIM domain protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TES
Synonyms (NCBI Gene) Gene synonyms aliases
TESS, TESS-2
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.2
Summary Summary of gene provided in NCBI Entrez Gene.
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli ce
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019575 hsa-miR-340-5p Sequencing 20371350
MIRT020280 hsa-miR-130b-3p Sequencing 20371350
MIRT021189 hsa-miR-186-5p Sequencing 20371350
MIRT025480 hsa-miR-34a-5p Proteomics 21566225
MIRT027620 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 21278383, 32814053
GO:0005634 Component Nucleus HDA 21630459
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606085 14620 ENSG00000135269
Protein
UniProt ID Q9UGI8
Protein name Testin (TESS)
Protein function Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:000
PDB 2IYB , 2XQN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06297 PET 109 193 PET Domain Domain
PF00412 LIM 236 297 LIM domain Domain
PF00412 LIM 301 357 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11420696}.
Sequence
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED
RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ
ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK
KYKSEALGVGDVK
LPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK
LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE
KPR
CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV
CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM
S
Sequence length 421
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 16909125
Unknown
Disease term Disease name Evidence References Source
Glaucoma Glaucoma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Astrocytoma Associate 24650279
Breast Neoplasms Inhibit 12695497
Breast Neoplasms Associate 25119600, 25809865
Carcinoma Renal Cell Associate 36530957
Glioblastoma Associate 25498217
Hypoxia Associate 35789607
Immunologic Deficiency Syndromes Associate 39925840
Leukemia T Cell Inhibit 26985820
Lymphatic Metastasis Associate 25119600
Melanoma Associate 22201996