Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
26031
Gene name Gene Name - the full gene name approved by the HGNC.
Oxysterol binding protein like 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OSBPL3
Synonyms (NCBI Gene) Gene synonyms aliases
ORP-3, ORP3, OSBP3
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encod
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027159 hsa-miR-103a-3p Sequencing 20371350
MIRT030982 hsa-miR-21-5p Microarray 18591254
MIRT031915 hsa-miR-16-5p Sequencing 20371350
MIRT031915 hsa-miR-16-5p CLASH 23622248
MIRT560858 hsa-miR-548e-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22190034, 32296183
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005829 Component Cytosol IBA 21873635
GO:0005829 Component Cytosol IDA 14593528
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606732 16370 ENSG00000070882
Protein
UniProt ID Q9H4L5
Protein name Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)
Protein function Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular com
PDB 7CYZ , 7DEI , 7DEJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15409 PH_8 56 145 Pleckstrin homology domain Domain
PF01237 Oxysterol_BP 527 871 Oxysterol-binding protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lun
Sequence
MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLK
KRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTE
EHIYHLKVKSEEVFDEWVSKLRHHR
MYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSIS
SRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLL
QSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVR
LHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREK
LKQLMEQDASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNL
AEENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISD
NLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDL
SKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRA
GSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGK
SMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKV
NFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYE
QYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERR
RVLEENHVEHQPRFFRKSDDDSWVSNGTYLE
LRKDLGFSKLDHPVLW
Sequence length 887
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of bile acids and bile salts
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
29221444
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease 17804789 ClinVar
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Aneuploidy Associate 32824360
Breast Neoplasms Associate 28027327
Carcinoma Hepatocellular Associate 36918840
Colorectal Neoplasms Inhibit 32824360
Colorectal Neoplasms Associate 34308980, 36517805, 37550605
Head and Neck Neoplasms Associate 33160365
Leukemia Lymphocytic Chronic B Cell Associate 18945750
Neoplasm Metastasis Inhibit 32824360
Neoplasm Metastasis Associate 36517805
Neoplasms Inhibit 32824360