ACOT11 (acyl-CoA thioesterase 11)

Gene

• Entrez ID: 26027
• Gene name: Acyl-CoA thioesterase 11
• Gene symbol: ACOT11
• Synonyms (NCBI Gene): BFIT, STARD14, THEA, THEM1
• Chromosome: 1
• Chromosome location: 1p32.3
• Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low te

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022706	hsa-miR-124-3p	Microarray	18668037
MIRT762866	hsa-miR-1205	CLIP-seq
MIRT762867	hsa-miR-221	CLIP-seq
MIRT762868	hsa-miR-222	CLIP-seq
MIRT762869	hsa-miR-3922-5p	CLIP-seq
MIRT762870	hsa-miR-4708-3p	CLIP-seq
MIRT762871	hsa-miR-4742-5p	CLIP-seq
MIRT1924883	hsa-miR-4501	CLIP-seq
MIRT2166090	hsa-miR-3940-5p	CLIP-seq
MIRT2166091	hsa-miR-4507	CLIP-seq
MIRT2166092	hsa-miR-548a-3p	CLIP-seq
MIRT2166093	hsa-miR-548e	CLIP-seq
MIRT2166094	hsa-miR-548f	CLIP-seq
MIRT2166095	hsa-miR-563	CLIP-seq
MIRT2468624	hsa-miR-1260	CLIP-seq
MIRT2468625	hsa-miR-1260b	CLIP-seq
MIRT2468626	hsa-miR-1827	CLIP-seq
MIRT2468627	hsa-miR-188-3p	CLIP-seq
MIRT2468628	hsa-miR-3156-3p	CLIP-seq
MIRT2468629	hsa-miR-3612	CLIP-seq
MIRT2468630	hsa-miR-650	CLIP-seq
MIRT2468631	hsa-miR-662	CLIP-seq
MIRT2468632	hsa-miR-940	CLIP-seq
MIRT2468624	hsa-miR-1260	CLIP-seq
MIRT2468625	hsa-miR-1260b	CLIP-seq
MIRT2468626	hsa-miR-1827	CLIP-seq
MIRT2468627	hsa-miR-188-3p	CLIP-seq
MIRT2468628	hsa-miR-3156-3p	CLIP-seq
MIRT2468629	hsa-miR-3612	CLIP-seq
MIRT2468630	hsa-miR-650	CLIP-seq
MIRT2468631	hsa-miR-662	CLIP-seq
MIRT2468632	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22897136
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	22897136
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	NAS	11696000
GO:0006637	Process	Acyl-CoA metabolic process	IBA
GO:0008289	Function	Lipid binding	IEA
GO:0009266	Process	Response to temperature stimulus	IEA
GO:0009266	Process	Response to temperature stimulus	ISS
GO:0009409	Process	Response to cold	IEA
GO:0009409	Process	Response to cold	ISS	11696000
GO:0016787	Function	Hydrolase activity	IEA
GO:0016790	Function	Thiolester hydrolase activity	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	11696000
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IDA	22897136
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	TAS	11696000
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0052816	Function	Long-chain fatty acyl-CoA hydrolase activity	IBA
GO:0052816	Function	Long-chain fatty acyl-CoA hydrolase activity	IDA	22897136
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	27110486

Other IDs

• MIM: 606803
• HGNC: 18156
• e!Ensembl: ENSG00000162390

Protein

• UniProt ID: Q8WXI4
• Protein name: Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2)
• Protein function: Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. {E
• PDB: 3FO5, 6VVQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03061	4HBT	62 → 135	Thioesterase superfamily	Domain
  PF03061	4HBT	234 → 309	Thioesterase superfamily	Domain
  PF01852	START	384 → 590	START domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.
• Sequence:

  MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQ
  RGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFN
  SSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAER
  RRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKTRVESVELVLPPHANHQGNTFGG
  QIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGV
  CVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYREASARKKIRL
  DRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLED
  DKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALG
  GHTKPQDFVILASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQ
  LTKCCWVRVSLTELVSASGFYSWGLESRSKGRRSDGWNGKLAGGHLSTLKAIPVAKINSR
  FGYLQDT

• Sequence length: 607

Pathways

Reactome:

Mitochondrial Fatty Acid Beta-Oxidation