Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25959
Gene name Gene Name - the full gene name approved by the HGNC.	KN motif and ankyrin repeat domains 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KANK2
Synonyms (NCBI Gene) Gene synonyms aliases	ANKRD25, MXRA3, NPHS16, PPKWH, SIP
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactiv

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SNP ID	Visualize variation	Clinical significance	Consequence
rs606231303	G>A	Pathogenic	Coding sequence variant, missense variant
rs1555816634	G>A	Pathogenic	Coding sequence variant, missense variant
rs1555820663	T>C	Pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016547	hsa-miR-193b-3p	Microarray	20304954
MIRT020755	hsa-miR-155-5p	Proteomics	18668040
MIRT022589	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT023699	hsa-miR-1-3p	Proteomics	18668040
MIRT029311	hsa-miR-26b-5p	Microarray	19088304
MIRT049313	hsa-miR-92a-3p	CLASH	23622248
MIRT044246	hsa-miR-106b-5p	CLASH	23622248
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661216	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT661215	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT661214	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661216	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT661215	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT661214	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661216	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT661215	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT661214	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661216	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT661215	hsa-miR-26a-1-3p	HITS-CLIP	23824327
MIRT661214	hsa-miR-26a-2-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617119	hsa-miR-7151-5p	HITS-CLIP	23824327
MIRT617118	hsa-miR-664a-3p	HITS-CLIP	23824327
MIRT617117	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT617116	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT617115	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT617114	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT617113	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT1078513	hsa-miR-130a	CLIP-seq
MIRT1078514	hsa-miR-130b	CLIP-seq
MIRT1078515	hsa-miR-1343	CLIP-seq
MIRT1078516	hsa-miR-141	CLIP-seq
MIRT1078517	hsa-miR-200a	CLIP-seq
MIRT1078518	hsa-miR-2276	CLIP-seq
MIRT1078519	hsa-miR-301a	CLIP-seq
MIRT1078520	hsa-miR-301b	CLIP-seq
MIRT1078521	hsa-miR-3159	CLIP-seq
MIRT1078522	hsa-miR-3616-5p	CLIP-seq
MIRT1078523	hsa-miR-3647-5p	CLIP-seq
MIRT1078524	hsa-miR-3662	CLIP-seq
MIRT1078525	hsa-miR-3666	CLIP-seq
MIRT1078526	hsa-miR-370	CLIP-seq
MIRT1078527	hsa-miR-3929	CLIP-seq
MIRT1078528	hsa-miR-3977	CLIP-seq
MIRT1078529	hsa-miR-4263	CLIP-seq
MIRT1078530	hsa-miR-4295	CLIP-seq
MIRT1078531	hsa-miR-4419b	CLIP-seq
MIRT1078532	hsa-miR-4466	CLIP-seq
MIRT1078533	hsa-miR-4478	CLIP-seq
MIRT1078534	hsa-miR-454	CLIP-seq
MIRT1078535	hsa-miR-4640-5p	CLIP-seq
MIRT1078536	hsa-miR-4666-5p	CLIP-seq
MIRT1078537	hsa-miR-4726-5p	CLIP-seq
MIRT1078538	hsa-miR-4768-5p	CLIP-seq
MIRT1078539	hsa-miR-4772-3p	CLIP-seq
MIRT1078540	hsa-miR-4795-5p	CLIP-seq
MIRT1078541	hsa-miR-519a	CLIP-seq
MIRT1078542	hsa-miR-519b-3p	CLIP-seq
MIRT1078543	hsa-miR-519c-3p	CLIP-seq
MIRT1078544	hsa-miR-548q	CLIP-seq
MIRT1078545	hsa-miR-573	CLIP-seq
MIRT1078546	hsa-miR-582-3p	CLIP-seq
MIRT1078547	hsa-miR-651	CLIP-seq
MIRT1078548	hsa-miR-659	CLIP-seq
MIRT1078549	hsa-miR-664	CLIP-seq
MIRT1078550	hsa-miR-675	CLIP-seq
MIRT1078551	hsa-miR-9	CLIP-seq
MIRT1078552	hsa-miR-126	CLIP-seq
MIRT1078553	hsa-miR-1281	CLIP-seq
MIRT1078554	hsa-miR-193a-3p	CLIP-seq
MIRT1078555	hsa-miR-193b	CLIP-seq
MIRT1078556	hsa-miR-200b	CLIP-seq
MIRT1078557	hsa-miR-200c	CLIP-seq
MIRT1078558	hsa-miR-2054	CLIP-seq
MIRT1078559	hsa-miR-3119	CLIP-seq
MIRT1078560	hsa-miR-3652	CLIP-seq
MIRT1078561	hsa-miR-4281	CLIP-seq
MIRT1078562	hsa-miR-429	CLIP-seq
MIRT1078563	hsa-miR-4430	CLIP-seq
MIRT1078564	hsa-miR-4469	CLIP-seq
MIRT1078565	hsa-miR-4505	CLIP-seq
MIRT1078566	hsa-miR-595	CLIP-seq
MIRT1078567	hsa-miR-892b	CLIP-seq
MIRT2019539	hsa-miR-3199	CLIP-seq
MIRT2019540	hsa-miR-320a	CLIP-seq
MIRT2019541	hsa-miR-320b	CLIP-seq
MIRT2019542	hsa-miR-320c	CLIP-seq
MIRT2019543	hsa-miR-320d	CLIP-seq
MIRT2019544	hsa-miR-330-3p	CLIP-seq
MIRT1078526	hsa-miR-370	CLIP-seq
MIRT2019545	hsa-miR-371-5p	CLIP-seq
MIRT2019546	hsa-miR-371b-5p	CLIP-seq
MIRT2019547	hsa-miR-4429	CLIP-seq
MIRT2019548	hsa-miR-4438	CLIP-seq
MIRT1078538	hsa-miR-4768-5p	CLIP-seq
MIRT2019549	hsa-miR-5095	CLIP-seq
MIRT2019550	hsa-miR-513c	CLIP-seq
MIRT2019551	hsa-miR-514b-5p	CLIP-seq
MIRT2019552	hsa-miR-562	CLIP-seq
MIRT2251379	hsa-miR-103b	CLIP-seq
MIRT2251380	hsa-miR-1178	CLIP-seq
MIRT2251381	hsa-miR-1183	CLIP-seq
MIRT2251382	hsa-miR-1208	CLIP-seq
MIRT2251383	hsa-miR-1252	CLIP-seq
MIRT2251384	hsa-miR-1253	CLIP-seq
MIRT2251385	hsa-miR-125a-5p	CLIP-seq
MIRT2251386	hsa-miR-125b	CLIP-seq
MIRT1078552	hsa-miR-126	CLIP-seq
MIRT1078515	hsa-miR-1343	CLIP-seq
MIRT2251387	hsa-miR-150	CLIP-seq
MIRT2251388	hsa-miR-185	CLIP-seq
MIRT1078554	hsa-miR-193a-3p	CLIP-seq
MIRT1078555	hsa-miR-193b	CLIP-seq
MIRT1078556	hsa-miR-200b	CLIP-seq
MIRT1078557	hsa-miR-200c	CLIP-seq
MIRT1078558	hsa-miR-2054	CLIP-seq
MIRT2251389	hsa-miR-2116	CLIP-seq
MIRT2251390	hsa-miR-22	CLIP-seq
MIRT2251391	hsa-miR-24	CLIP-seq
MIRT2251392	hsa-miR-2467-3p	CLIP-seq
MIRT2251393	hsa-miR-298	CLIP-seq
MIRT2251394	hsa-miR-3074-3p	CLIP-seq
MIRT1078559	hsa-miR-3119	CLIP-seq
MIRT2251395	hsa-miR-3123	CLIP-seq
MIRT2251396	hsa-miR-3137	CLIP-seq
MIRT2251397	hsa-miR-3138	CLIP-seq
MIRT2019539	hsa-miR-3199	CLIP-seq
MIRT2251398	hsa-miR-3201	CLIP-seq
MIRT2019540	hsa-miR-320a	CLIP-seq
MIRT2019541	hsa-miR-320b	CLIP-seq
MIRT2019542	hsa-miR-320c	CLIP-seq
MIRT2019543	hsa-miR-320d	CLIP-seq
MIRT2019544	hsa-miR-330-3p	CLIP-seq
MIRT2251399	hsa-miR-338-3p	CLIP-seq
MIRT2251400	hsa-miR-339-5p	CLIP-seq
MIRT2251401	hsa-miR-34a	CLIP-seq
MIRT2251402	hsa-miR-34c-5p	CLIP-seq
MIRT2251403	hsa-miR-3609	CLIP-seq
MIRT2251404	hsa-miR-361-5p	CLIP-seq
MIRT1078522	hsa-miR-3616-5p	CLIP-seq
MIRT2251405	hsa-miR-3620	CLIP-seq
MIRT1078523	hsa-miR-3647-5p	CLIP-seq
MIRT2251406	hsa-miR-3650	CLIP-seq
MIRT2251407	hsa-miR-3679-3p	CLIP-seq
MIRT1078526	hsa-miR-370	CLIP-seq
MIRT2019545	hsa-miR-371-5p	CLIP-seq
MIRT2019546	hsa-miR-371b-5p	CLIP-seq
MIRT2251408	hsa-miR-383	CLIP-seq
MIRT1078527	hsa-miR-3929	CLIP-seq
MIRT2251409	hsa-miR-4280	CLIP-seq
MIRT1078562	hsa-miR-429	CLIP-seq
MIRT2251410	hsa-miR-4291	CLIP-seq
MIRT2251411	hsa-miR-4306	CLIP-seq
MIRT2251412	hsa-miR-4319	CLIP-seq
MIRT2251413	hsa-miR-4324	CLIP-seq
MIRT1078531	hsa-miR-4419b	CLIP-seq
MIRT2019547	hsa-miR-4429	CLIP-seq
MIRT2251414	hsa-miR-4437	CLIP-seq
MIRT2019548	hsa-miR-4438	CLIP-seq
MIRT1078533	hsa-miR-4478	CLIP-seq
MIRT2251415	hsa-miR-449a	CLIP-seq
MIRT2251416	hsa-miR-449b	CLIP-seq
MIRT1078535	hsa-miR-4640-5p	CLIP-seq
MIRT2251417	hsa-miR-4644	CLIP-seq
MIRT2251418	hsa-miR-4677-5p	CLIP-seq
MIRT2251419	hsa-miR-4680-5p	CLIP-seq
MIRT2251420	hsa-miR-4685-5p	CLIP-seq
MIRT2251421	hsa-miR-4708-5p	CLIP-seq
MIRT2251422	hsa-miR-4711-5p	CLIP-seq
MIRT2251423	hsa-miR-4716-5p	CLIP-seq
MIRT1078537	hsa-miR-4726-5p	CLIP-seq
MIRT2251424	hsa-miR-4729	CLIP-seq
MIRT2251425	hsa-miR-4732-5p	CLIP-seq
MIRT2251426	hsa-miR-4772-5p	CLIP-seq
MIRT2251427	hsa-miR-4781-5p	CLIP-seq
MIRT2251428	hsa-miR-4786-3p	CLIP-seq
MIRT2251429	hsa-miR-4791	CLIP-seq
MIRT1078540	hsa-miR-4795-5p	CLIP-seq
MIRT2251430	hsa-miR-4800-5p	CLIP-seq
MIRT2251431	hsa-miR-486-3p	CLIP-seq
MIRT2019549	hsa-miR-5095	CLIP-seq
MIRT2019550	hsa-miR-513c	CLIP-seq
MIRT2019551	hsa-miR-514b-5p	CLIP-seq
MIRT1078541	hsa-miR-519a	CLIP-seq
MIRT1078542	hsa-miR-519b-3p	CLIP-seq
MIRT1078543	hsa-miR-519c-3p	CLIP-seq
MIRT2251432	hsa-miR-545	CLIP-seq
MIRT2251433	hsa-miR-548aa	CLIP-seq
MIRT2251434	hsa-miR-548ah	CLIP-seq
MIRT2019552	hsa-miR-562	CLIP-seq
MIRT1078545	hsa-miR-573	CLIP-seq
MIRT2251435	hsa-miR-579	CLIP-seq
MIRT1078566	hsa-miR-595	CLIP-seq
MIRT2251436	hsa-miR-643	CLIP-seq
MIRT1078548	hsa-miR-659	CLIP-seq
MIRT2251437	hsa-miR-662	CLIP-seq
MIRT1078549	hsa-miR-664	CLIP-seq
MIRT2251438	hsa-miR-711	CLIP-seq
MIRT2251439	hsa-miR-720	CLIP-seq
MIRT2251440	hsa-miR-744	CLIP-seq
MIRT1078567	hsa-miR-892b	CLIP-seq
MIRT1078551	hsa-miR-9	CLIP-seq
MIRT2251381	hsa-miR-1183	CLIP-seq
MIRT2251382	hsa-miR-1208	CLIP-seq
MIRT2251396	hsa-miR-3137	CLIP-seq
MIRT2251420	hsa-miR-4685-5p	CLIP-seq
MIRT2438068	hsa-miR-1224-3p	CLIP-seq
MIRT2438069	hsa-miR-1260	CLIP-seq
MIRT2438070	hsa-miR-1260b	CLIP-seq
MIRT2438071	hsa-miR-1280	CLIP-seq
MIRT2438072	hsa-miR-188-3p	CLIP-seq
MIRT2438073	hsa-miR-1976	CLIP-seq
MIRT2438074	hsa-miR-3065-5p	CLIP-seq
MIRT2438075	hsa-miR-3126-3p	CLIP-seq
MIRT2438076	hsa-miR-3128	CLIP-seq
MIRT2438077	hsa-miR-3156-3p	CLIP-seq
MIRT2438078	hsa-miR-3671	CLIP-seq
MIRT2438079	hsa-miR-4640-3p	CLIP-seq
MIRT2438080	hsa-miR-4667-3p	CLIP-seq
MIRT2438081	hsa-miR-4720-5p	CLIP-seq
MIRT2438082	hsa-miR-4762-5p	CLIP-seq
MIRT1078539	hsa-miR-4772-3p	CLIP-seq
MIRT2438083	hsa-miR-4799-3p	CLIP-seq
MIRT2438084	hsa-miR-607	CLIP-seq
MIRT2452108	hsa-miR-1182	CLIP-seq
MIRT2452109	hsa-miR-1275	CLIP-seq
MIRT2452110	hsa-miR-299-3p	CLIP-seq
MIRT2452111	hsa-miR-3151	CLIP-seq
MIRT2452112	hsa-miR-3179	CLIP-seq
MIRT1078526	hsa-miR-370	CLIP-seq
MIRT1078527	hsa-miR-3929	CLIP-seq
MIRT1078531	hsa-miR-4419b	CLIP-seq
MIRT2452113	hsa-miR-4447	CLIP-seq
MIRT2452114	hsa-miR-4472	CLIP-seq
MIRT1078533	hsa-miR-4478	CLIP-seq
MIRT2452115	hsa-miR-4525	CLIP-seq
MIRT2452116	hsa-miR-4665-5p	CLIP-seq
MIRT2452117	hsa-miR-4723-5p	CLIP-seq
MIRT2452118	hsa-miR-491-5p	CLIP-seq
MIRT2452119	hsa-miR-625	CLIP-seq
MIRT2251439	hsa-miR-720	CLIP-seq
MIRT2452109	hsa-miR-1275	CLIP-seq
MIRT2452110	hsa-miR-299-3p	CLIP-seq
MIRT2452111	hsa-miR-3151	CLIP-seq
MIRT2452112	hsa-miR-3179	CLIP-seq
MIRT2019539	hsa-miR-3199	CLIP-seq
MIRT2019548	hsa-miR-4438	CLIP-seq
MIRT2452113	hsa-miR-4447	CLIP-seq
MIRT2452114	hsa-miR-4472	CLIP-seq
MIRT2452115	hsa-miR-4525	CLIP-seq
MIRT2452116	hsa-miR-4665-5p	CLIP-seq
MIRT2452117	hsa-miR-4723-5p	CLIP-seq
MIRT2554666	hsa-miR-4794	CLIP-seq
MIRT2452118	hsa-miR-491-5p	CLIP-seq
MIRT2019549	hsa-miR-5095	CLIP-seq
MIRT2452119	hsa-miR-625	CLIP-seq
MIRT2452109	hsa-miR-1275	CLIP-seq
MIRT2452110	hsa-miR-299-3p	CLIP-seq
MIRT2452111	hsa-miR-3151	CLIP-seq
MIRT2452112	hsa-miR-3179	CLIP-seq
MIRT2452113	hsa-miR-4447	CLIP-seq
MIRT2452114	hsa-miR-4472	CLIP-seq
MIRT2452115	hsa-miR-4525	CLIP-seq
MIRT2452116	hsa-miR-4665-5p	CLIP-seq
MIRT2452117	hsa-miR-4723-5p	CLIP-seq
MIRT2554666	hsa-miR-4794	CLIP-seq
MIRT2452118	hsa-miR-491-5p	CLIP-seq
MIRT2452119	hsa-miR-625	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	17476305
GO:0005515	Function	Protein binding	IPI	17476305, 21516116, 22371500, 24722188, 25416956, 25961457, 29183992, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17476305, 25961457
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	22371500
GO:0005739	Component	Mitochondrion	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IBA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	17476305
GO:0030837	Process	Negative regulation of actin filament polymerization	IEA
GO:0033147	Process	Negative regulation of intracellular estrogen receptor signaling pathway	IBA
GO:0033147	Process	Negative regulation of intracellular estrogen receptor signaling pathway	IDA	17476305
GO:0035023	Process	Regulation of Rho protein signal transduction	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IMP	25961457
GO:0043069	Process	Negative regulation of programmed cell death	IDA	22371500
GO:0070563	Process	Negative regulation of vitamin D receptor signaling pathway	IBA
GO:0070563	Process	Negative regulation of vitamin D receptor signaling pathway	IMP	24671081
GO:0072073	Process	Kidney epithelium development	IMP	25961457
GO:0090521	Process	Podocyte cell migration	IEA
GO:0090521	Process	Podocyte cell migration	IMP	25961457
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IBA
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	17476305

MIM	HGNC	e!Ensembl
614610	29300	ENSG00000197256

Protein

UniProt ID

Q63ZY3

Protein name

KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)

Protein function

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor

PDB

4HBD , 5YBV , 6TMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12075	KN_motif	31 → 69	KN motif	Motif
PF00023	Ank	666 → 699	Ankyrin repeat	Repeat
PF13637	Ank_4	739 → 792		Repeat
PF12796	Ank_2	764 → 834	Ankyrin repeats (3 copies)	Repeat

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). {ECO:0000269|PubMed:17996375, ECO:0000269|PubMed:20720434}.

Sequence

MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLR
RVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGF
NPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPP
SAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPT
AGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKAL
QELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPY
GTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPE
VPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVR
SIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPS
VAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLA
LEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVV
NIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIE
TVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCAC
EHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSD
DESPTSSSAEE

Sequence length

851

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Nephrotic Syndrome	Nephrotic syndrome 16	rs1555816634	N/A
Palmoplantar Keratoderma And Woolly Hair	Wooly hair-palmoplantar keratoderma syndrome	rs606231303	N/A

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Carpal Tunnel Syndrome	Carpal tunnel syndrome	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Diabetes Mellitus Type 2	Associate	35271662
Melanoma	Associate	37460977
Sarcopenia	Associate	35271662

KANK2 (KN motif and ankyrin repeat domains 2)