TAS2R43 (taste 2 receptor member 43)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
259289
Gene name Gene Name - the full gene name approved by the HGNC.
Taste 2 receptor member 43
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAS2R43
Synonyms (NCBI Gene) Gene synonyms aliases
T2R43, T2R52
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For furth
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0001580 Process Detection of chemical stimulus involved in sensory perception of bitter taste IBA 21873635
GO:0001580 Process Detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576, 20022913
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005886 Component Plasma membrane TAS
GO:0007186 Process G protein-coupled receptor signaling pathway IC 16720576
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
612668 18875 ENSG00000255374
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P59537
Protein name Taste receptor type 2 member 43 (T2R43) (Taste receptor type 2 member 52) (T2R52)
Protein function Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners sacc
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05296 TAS2R 1 → 298 Taste receptor protein (TAS2R) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia. {ECO:0000269|PubMed:19628819}.
Sequence
Sequence length 309
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Taste transduction   G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Show/Hide Text Mining Associations (1)
Associations from Text Mining
Disease Name Relationship Type References
Balkan Nephropathy Associate 23050764