Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25898
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger and CHY zinc finger domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RCHY1
Synonyms (NCBI Gene) Gene synonyms aliases
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regul
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT1298229 hsa-miR-1246 CLIP-seq
MIRT1298230 hsa-miR-1255a CLIP-seq
MIRT1298231 hsa-miR-1255b CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 19043414
GO:0002039 Function P53 binding IPI 19043414
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005515 Function Protein binding IPI 15781263, 17568776, 19043414, 19483087, 20452352, 21988832, 25416956, 27519799, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607680 17479 ENSG00000163743
Protein
UniProt ID Q96PM5
Protein name RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin trans
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitinati
PDB 2JRJ , 2K2C , 2K2D , 7YNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05495 zf-CHY 20 93 CHY zinc finger Domain
PF13639 zf-RING_2 143 187 Ring finger domain Domain
PF14599 zinc_ribbon_6 191 249 Zinc-ribbon Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  p53 signaling pathway
Ubiquitin mediated proteolysis
Measles
  Translesion Synthesis by POLH
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 28191284
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 22491018
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 19551892
Carcinoma Non Small Cell Lung Associate 19895323
Lung Neoplasms Associate 19895323
Neoplasm Invasiveness Stimulate 19551892
Neoplasms Associate 15919663, 17950244, 20008555, 21852228, 24367557
Prostatic Neoplasms Associate 16914734, 17721809, 23159636
Severe Acute Respiratory Syndrome Associate 27519799