Gene Gene information from NCBI Gene database.
Entrez ID 25898
Gene name Ring finger and CHY zinc finger domain containing 1
Gene symbol RCHY1
Synonyms (NCBI Gene)
ARNIPCHIMPPIRH2PRO1996RNF199ZCHYZNF363
Chromosome 4
Chromosome location 4q21.1
Summary The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regul
miRNA miRNA information provided by mirtarbase database.
456
miRTarBase ID miRNA Experiments Reference
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT1298229 hsa-miR-1246 CLIP-seq
MIRT1298230 hsa-miR-1255a CLIP-seq
MIRT1298231 hsa-miR-1255b CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 19043414
GO:0002039 Function P53 binding IPI 19043414, 19483087
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005515 Function Protein binding IPI 15781263, 17568776, 19043414, 19483087, 20452352, 21988832, 25416956, 27519799, 31515488, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607680 17479 ENSG00000163743
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96PM5
Protein name RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin trans
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitinati
PDB 2JRJ , 2K2C , 2K2D , 7YNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05495 zf-CHY 20 93 CHY zinc finger Domain
PF13639 zf-RING_2 143 187 Ring finger domain Domain
PF14599 zinc_ribbon_6 191 249 Zinc-ribbon Domain
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  p53 signaling pathway
Ubiquitin mediated proteolysis
Measles
  Translesion Synthesis by POLH
Antigen processing: Ubiquitination & Proteasome degradation