Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
25898
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Ring finger and CHY zinc finger domain containing 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
RCHY1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363 |
Chromosome
Chromosome number
|
4 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
4q21.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regul |
UniProt ID |
Q96PM5
|
Protein name |
RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin trans |
Protein function |
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitinati |
PDB |
2JRJ
,
2K2C
,
2K2D
,
7YNX
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF05495
|
zf-CHY |
20 → 93 |
CHY zinc finger |
Domain |
PF13639
|
zf-RING_2 |
143 → 187 |
Ring finger domain |
Domain |
PF14599
|
zinc_ribbon_6 |
191 → 249 |
Zinc-ribbon |
Domain |
|
Sequence |
|
Sequence length |
261 |
Interactions |
View interactions
|