ARMC8 (armadillo repeat containing 8)

Gene

• Entrez ID: 25852
• Gene name: Armadillo repeat containing 8
• Gene symbol: ARMC8
• Synonyms (NCBI Gene): GID5, HSPC056, S863-2, VID28
• Chromosome: 3
• Chromosome location: 3q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030148	hsa-miR-26b-5p	Microarray	19088304
MIRT051825	hsa-let-7c-5p	CLASH	23622248
MIRT051358	hsa-let-7f-5p	CLASH	23622248
MIRT038998	hsa-let-7a-3p	CLASH	23622248
MIRT441182	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT441182	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT728308	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT728307	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT799222	hsa-miR-105	CLIP-seq
MIRT799223	hsa-miR-1252	CLIP-seq
MIRT799224	hsa-miR-1343	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799227	hsa-miR-204	CLIP-seq
MIRT799228	hsa-miR-211	CLIP-seq
MIRT799229	hsa-miR-219-5p	CLIP-seq
MIRT799230	hsa-miR-2467-5p	CLIP-seq
MIRT799231	hsa-miR-29a	CLIP-seq
MIRT799232	hsa-miR-29b	CLIP-seq
MIRT799233	hsa-miR-29c	CLIP-seq
MIRT799234	hsa-miR-3065-3p	CLIP-seq
MIRT799235	hsa-miR-3120-3p	CLIP-seq
MIRT799236	hsa-miR-3121-3p	CLIP-seq
MIRT799237	hsa-miR-3126-3p	CLIP-seq
MIRT799238	hsa-miR-3137	CLIP-seq
MIRT799239	hsa-miR-3140-3p	CLIP-seq
MIRT799240	hsa-miR-3148	CLIP-seq
MIRT799241	hsa-miR-3150a-3p	CLIP-seq
MIRT799242	hsa-miR-3154	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT799244	hsa-miR-3175	CLIP-seq
MIRT799245	hsa-miR-3176	CLIP-seq
MIRT799246	hsa-miR-3183	CLIP-seq
MIRT799247	hsa-miR-3188	CLIP-seq
MIRT799248	hsa-miR-3192	CLIP-seq
MIRT799249	hsa-miR-3662	CLIP-seq
MIRT799250	hsa-miR-3908	CLIP-seq
MIRT799251	hsa-miR-3922-3p	CLIP-seq
MIRT799252	hsa-miR-3938	CLIP-seq
MIRT799253	hsa-miR-3975	CLIP-seq
MIRT799254	hsa-miR-4273	CLIP-seq
MIRT799255	hsa-miR-4308	CLIP-seq
MIRT799256	hsa-miR-4314	CLIP-seq
MIRT799257	hsa-miR-4435	CLIP-seq
MIRT799258	hsa-miR-4445	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT799261	hsa-miR-4646-5p	CLIP-seq
MIRT799262	hsa-miR-4652-3p	CLIP-seq
MIRT799263	hsa-miR-4667-5p	CLIP-seq
MIRT799264	hsa-miR-4677-5p	CLIP-seq
MIRT799265	hsa-miR-4678	CLIP-seq
MIRT799266	hsa-miR-4700-5p	CLIP-seq
MIRT799267	hsa-miR-4704-3p	CLIP-seq
MIRT799268	hsa-miR-4720-3p	CLIP-seq
MIRT799269	hsa-miR-4723-3p	CLIP-seq
MIRT799270	hsa-miR-4747-5p	CLIP-seq
MIRT799271	hsa-miR-4749-3p	CLIP-seq
MIRT799272	hsa-miR-4755-5p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT799274	hsa-miR-4778-5p	CLIP-seq
MIRT799275	hsa-miR-4780	CLIP-seq
MIRT799276	hsa-miR-4782-3p	CLIP-seq
MIRT799277	hsa-miR-4789-5p	CLIP-seq
MIRT799278	hsa-miR-4793-5p	CLIP-seq
MIRT799279	hsa-miR-4799-5p	CLIP-seq
MIRT799280	hsa-miR-4804-3p	CLIP-seq
MIRT799281	hsa-miR-485-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT799283	hsa-miR-508-3p	CLIP-seq
MIRT799284	hsa-miR-518a-5p	CLIP-seq
MIRT799285	hsa-miR-527	CLIP-seq
MIRT799286	hsa-miR-548g	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT799288	hsa-miR-576-5p	CLIP-seq
MIRT799289	hsa-miR-623	CLIP-seq
MIRT799290	hsa-miR-624	CLIP-seq
MIRT799291	hsa-miR-630	CLIP-seq
MIRT799292	hsa-miR-767-5p	CLIP-seq
MIRT799293	hsa-miR-875-3p	CLIP-seq
MIRT799294	hsa-miR-939	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799295	hsa-miR-300	CLIP-seq
MIRT799296	hsa-miR-3133	CLIP-seq
MIRT799297	hsa-miR-338-5p	CLIP-seq
MIRT799298	hsa-miR-381	CLIP-seq
MIRT799299	hsa-miR-4312	CLIP-seq
MIRT799300	hsa-miR-4635	CLIP-seq
MIRT799301	hsa-miR-4643	CLIP-seq
MIRT799302	hsa-miR-4666-3p	CLIP-seq
MIRT799303	hsa-miR-4803	CLIP-seq
MIRT799304	hsa-miR-488	CLIP-seq
MIRT799305	hsa-miR-548a-3p	CLIP-seq
MIRT799306	hsa-miR-548e	CLIP-seq
MIRT799307	hsa-miR-548f	CLIP-seq
MIRT799308	hsa-miR-581	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT1935996	hsa-miR-1229	CLIP-seq
MIRT1935997	hsa-miR-1298	CLIP-seq
MIRT1935998	hsa-miR-132	CLIP-seq
MIRT1935999	hsa-miR-212	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT1936001	hsa-miR-4422	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT1936002	hsa-miR-4719	CLIP-seq
MIRT1936003	hsa-miR-4796-3p	CLIP-seq
MIRT1936004	hsa-miR-486-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT1936005	hsa-miR-520g	CLIP-seq
MIRT1936006	hsa-miR-520h	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT1936007	hsa-miR-604	CLIP-seq
MIRT1936008	hsa-miR-647	CLIP-seq
MIRT1936009	hsa-miR-664	CLIP-seq
MIRT2176022	hsa-miR-103a	CLIP-seq
MIRT799222	hsa-miR-105	CLIP-seq
MIRT2176023	hsa-miR-107	CLIP-seq
MIRT2176024	hsa-miR-1184	CLIP-seq
MIRT1935996	hsa-miR-1229	CLIP-seq
MIRT799223	hsa-miR-1252	CLIP-seq
MIRT1935997	hsa-miR-1298	CLIP-seq
MIRT2176025	hsa-miR-146a	CLIP-seq
MIRT2176026	hsa-miR-146b-5p	CLIP-seq
MIRT2176027	hsa-miR-188-5p	CLIP-seq
MIRT2176028	hsa-miR-1915	CLIP-seq
MIRT799225	hsa-miR-19a	CLIP-seq
MIRT799226	hsa-miR-19b	CLIP-seq
MIRT2176029	hsa-miR-2053	CLIP-seq
MIRT799230	hsa-miR-2467-5p	CLIP-seq
MIRT799231	hsa-miR-29a	CLIP-seq
MIRT799232	hsa-miR-29b	CLIP-seq
MIRT799233	hsa-miR-29c	CLIP-seq
MIRT799234	hsa-miR-3065-3p	CLIP-seq
MIRT799236	hsa-miR-3121-3p	CLIP-seq
MIRT2176030	hsa-miR-3136-3p	CLIP-seq
MIRT799242	hsa-miR-3154	CLIP-seq
MIRT799243	hsa-miR-3164	CLIP-seq
MIRT2176031	hsa-miR-3173-3p	CLIP-seq
MIRT799245	hsa-miR-3176	CLIP-seq
MIRT799247	hsa-miR-3188	CLIP-seq
MIRT2176032	hsa-miR-342-3p	CLIP-seq
MIRT2176033	hsa-miR-3665	CLIP-seq
MIRT2176034	hsa-miR-3689d	CLIP-seq
MIRT2176035	hsa-miR-371-3p	CLIP-seq
MIRT2176036	hsa-miR-371b-3p	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT799251	hsa-miR-3922-3p	CLIP-seq
MIRT799253	hsa-miR-3975	CLIP-seq
MIRT2176037	hsa-miR-4251	CLIP-seq
MIRT2176038	hsa-miR-4293	CLIP-seq
MIRT2176039	hsa-miR-4324	CLIP-seq
MIRT2176040	hsa-miR-4457	CLIP-seq
MIRT2176041	hsa-miR-448	CLIP-seq
MIRT799259	hsa-miR-450b-5p	CLIP-seq
MIRT799260	hsa-miR-455-3p	CLIP-seq
MIRT2176042	hsa-miR-4641	CLIP-seq
MIRT2176043	hsa-miR-4654	CLIP-seq
MIRT799265	hsa-miR-4678	CLIP-seq
MIRT2176044	hsa-miR-4688	CLIP-seq
MIRT1936002	hsa-miR-4719	CLIP-seq
MIRT2176045	hsa-miR-4728-3p	CLIP-seq
MIRT799273	hsa-miR-4761-5p	CLIP-seq
MIRT2176046	hsa-miR-4769-5p	CLIP-seq
MIRT799274	hsa-miR-4778-5p	CLIP-seq
MIRT1936003	hsa-miR-4796-3p	CLIP-seq
MIRT799281	hsa-miR-485-5p	CLIP-seq
MIRT1936004	hsa-miR-486-5p	CLIP-seq
MIRT799282	hsa-miR-507	CLIP-seq
MIRT2176047	hsa-miR-515-3p	CLIP-seq
MIRT799284	hsa-miR-518a-5p	CLIP-seq
MIRT2176048	hsa-miR-519e	CLIP-seq
MIRT1936005	hsa-miR-520g	CLIP-seq
MIRT1936006	hsa-miR-520h	CLIP-seq
MIRT799285	hsa-miR-527	CLIP-seq
MIRT799286	hsa-miR-548g	CLIP-seq
MIRT2176049	hsa-miR-550a	CLIP-seq
MIRT799287	hsa-miR-557	CLIP-seq
MIRT2176050	hsa-miR-569	CLIP-seq
MIRT2176051	hsa-miR-589	CLIP-seq
MIRT1936007	hsa-miR-604	CLIP-seq
MIRT799290	hsa-miR-624	CLIP-seq
MIRT799291	hsa-miR-630	CLIP-seq
MIRT1936008	hsa-miR-647	CLIP-seq
MIRT1936009	hsa-miR-664	CLIP-seq
MIRT2176052	hsa-miR-671-5p	CLIP-seq
MIRT2176053	hsa-miR-764	CLIP-seq
MIRT799292	hsa-miR-767-5p	CLIP-seq
MIRT2176054	hsa-miR-873	CLIP-seq
MIRT2176055	hsa-miR-890	CLIP-seq
MIRT2479291	hsa-miR-137	CLIP-seq
MIRT2479292	hsa-miR-3177-3p	CLIP-seq
MIRT2479293	hsa-miR-338-3p	CLIP-seq
MIRT2479294	hsa-miR-3613-3p	CLIP-seq
MIRT2479295	hsa-miR-3682-5p	CLIP-seq
MIRT1936000	hsa-miR-377	CLIP-seq
MIRT2479296	hsa-miR-4252	CLIP-seq
MIRT2479297	hsa-miR-4328	CLIP-seq
MIRT2479298	hsa-miR-4530	CLIP-seq
MIRT2479299	hsa-miR-4659a-3p	CLIP-seq
MIRT2479300	hsa-miR-4659b-3p	CLIP-seq
MIRT2479301	hsa-miR-4762-5p	CLIP-seq
MIRT799279	hsa-miR-4799-5p	CLIP-seq
MIRT2479302	hsa-miR-495	CLIP-seq
MIRT2479303	hsa-miR-522	CLIP-seq
MIRT2479304	hsa-miR-548ac	CLIP-seq
MIRT2479305	hsa-miR-548ae	CLIP-seq
MIRT2479306	hsa-miR-548aj	CLIP-seq
MIRT2479307	hsa-miR-548am	CLIP-seq
MIRT2479308	hsa-miR-548d-3p	CLIP-seq
MIRT2479309	hsa-miR-548x	CLIP-seq
MIRT2479310	hsa-miR-548z	CLIP-seq
MIRT2479311	hsa-miR-616	CLIP-seq
MIRT2479312	hsa-miR-642b	CLIP-seq
MIRT2479292	hsa-miR-3177-3p	CLIP-seq
MIRT2479293	hsa-miR-338-3p	CLIP-seq
MIRT2479294	hsa-miR-3613-3p	CLIP-seq
MIRT2479296	hsa-miR-4252	CLIP-seq
MIRT2479298	hsa-miR-4530	CLIP-seq
MIRT2479311	hsa-miR-616	CLIP-seq
MIRT2479312	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	29911972
GO:0005515	Function	Protein binding	IPI	17467196, 25416956, 27173435, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	17467196
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	17467196
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0034657	Component	GID complex	IBA
GO:0035580	Component	Specific granule lumen	TAS
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:1904724	Component	Tertiary granule lumen	TAS

Other IDs

• MIM: 618521
• HGNC: 24999
• e!Ensembl: ENSG00000114098

Protein

• UniProt ID: Q8IUR7
• Protein name: Armadillo repeat-containing protein 8
• Protein function: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.
• PDB: 7NSC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00514	Arm	50 → 92	Armadillo/beta-catenin-like repeat	Repeat

• Sequence:

  MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVL
  GAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLK
  FIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDH
  QTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIF
  VKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEG
  AETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQA
  AFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRT
  SFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSE
  NPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLS
  TRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDIL
  QKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNL
  CDKAKMALQQYLA

• Sequence length: 673

Pathways

Reactome:

Neutrophil degranulation