Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	25842
Gene name	Anti-silencing function 1A histone chaperone
Gene symbol	ASF1A
Synonyms (NCBI Gene)	CGI-98CIAHSPC146
Chromosome	6
Chromosome location	6q22.31
Summary	This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019628	hsa-miR-340-5p	Sequencing	20371350
MIRT020266	hsa-miR-130b-3p	Sequencing	20371350
MIRT028099	hsa-miR-93-5p	Sequencing	20371350
MIRT217679	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT217678	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT559425	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT244053	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT559424	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT217676	hsa-miR-6083	PAR-CLIP	21572407
MIRT559423	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT217679	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT217678	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT559425	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT244053	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT559424	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT217676	hsa-miR-6083	PAR-CLIP	21572407
MIRT559423	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT802707	hsa-miR-105	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT802709	hsa-miR-1265	CLIP-seq
MIRT802710	hsa-miR-132	CLIP-seq
MIRT802711	hsa-miR-139-5p	CLIP-seq
MIRT802712	hsa-miR-2052	CLIP-seq
MIRT802713	hsa-miR-212	CLIP-seq
MIRT802714	hsa-miR-23a	CLIP-seq
MIRT802715	hsa-miR-23b	CLIP-seq
MIRT802716	hsa-miR-23c	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT802720	hsa-miR-3127-5p	CLIP-seq
MIRT802721	hsa-miR-3148	CLIP-seq
MIRT802722	hsa-miR-3168	CLIP-seq
MIRT802723	hsa-miR-3188	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT802726	hsa-miR-3647-3p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT802729	hsa-miR-369-3p	CLIP-seq
MIRT802730	hsa-miR-374a	CLIP-seq
MIRT802731	hsa-miR-374b	CLIP-seq
MIRT802732	hsa-miR-3978	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT802734	hsa-miR-4270	CLIP-seq
MIRT802735	hsa-miR-4289	CLIP-seq
MIRT802736	hsa-miR-4307	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT802738	hsa-miR-4441	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT802740	hsa-miR-4668-3p	CLIP-seq
MIRT802741	hsa-miR-4700-3p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT802743	hsa-miR-4788	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT802747	hsa-miR-569	CLIP-seq
MIRT802748	hsa-miR-626	CLIP-seq
MIRT802749	hsa-miR-633	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT1937036	hsa-miR-4719	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT1937037	hsa-miR-561	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802709	hsa-miR-1265	CLIP-seq
MIRT802711	hsa-miR-139-5p	CLIP-seq
MIRT2176826	hsa-miR-200b	CLIP-seq
MIRT2176827	hsa-miR-200c	CLIP-seq
MIRT802712	hsa-miR-2052	CLIP-seq
MIRT2176828	hsa-miR-21	CLIP-seq
MIRT802714	hsa-miR-23a	CLIP-seq
MIRT802715	hsa-miR-23b	CLIP-seq
MIRT802716	hsa-miR-23c	CLIP-seq
MIRT802720	hsa-miR-3127-5p	CLIP-seq
MIRT802722	hsa-miR-3168	CLIP-seq
MIRT2176829	hsa-miR-340	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT802734	hsa-miR-4270	CLIP-seq
MIRT802735	hsa-miR-4289	CLIP-seq
MIRT2176830	hsa-miR-429	CLIP-seq
MIRT802736	hsa-miR-4307	CLIP-seq
MIRT802738	hsa-miR-4441	CLIP-seq
MIRT802741	hsa-miR-4700-3p	CLIP-seq
MIRT2176831	hsa-miR-4775	CLIP-seq
MIRT802743	hsa-miR-4788	CLIP-seq
MIRT2176832	hsa-miR-590-5p	CLIP-seq
MIRT802749	hsa-miR-633	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT2480157	hsa-miR-140-5p	CLIP-seq
MIRT2480158	hsa-miR-2116	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT2480159	hsa-miR-3145-3p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT2480160	hsa-miR-3194-3p	CLIP-seq
MIRT2480161	hsa-miR-3545-5p	CLIP-seq
MIRT2480162	hsa-miR-3616-5p	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT2480163	hsa-miR-3647-5p	CLIP-seq
MIRT2480164	hsa-miR-3663-5p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT2480165	hsa-miR-375	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT2480166	hsa-miR-4273	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT2480167	hsa-miR-4460	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT2480168	hsa-miR-4677-5p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT2480169	hsa-miR-4753-5p	CLIP-seq
MIRT2480170	hsa-miR-4799-5p	CLIP-seq
MIRT2480171	hsa-miR-490-3p	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT2480172	hsa-miR-573	CLIP-seq
MIRT2480173	hsa-miR-601	CLIP-seq
MIRT2480174	hsa-miR-607	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT2480157	hsa-miR-140-5p	CLIP-seq
MIRT2480158	hsa-miR-2116	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT2480159	hsa-miR-3145-3p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT2480160	hsa-miR-3194-3p	CLIP-seq
MIRT2480161	hsa-miR-3545-5p	CLIP-seq
MIRT2480162	hsa-miR-3616-5p	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT2480163	hsa-miR-3647-5p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT2480165	hsa-miR-375	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT2480166	hsa-miR-4273	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT2480167	hsa-miR-4460	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT2480168	hsa-miR-4677-5p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT2480169	hsa-miR-4753-5p	CLIP-seq
MIRT2480170	hsa-miR-4799-5p	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT2480172	hsa-miR-573	CLIP-seq
MIRT2480174	hsa-miR-607	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	18417535, 27338793, 27797818
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	14718166
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003682	Function	Chromatin binding	NAS	10759893
GO:0005515	Function	Protein binding	IPI	16189514, 16980972, 19029251, 19862764, 21217774, 22407294, 23075851, 24981860, 25416956, 26167883, 26496610, 28514442, 31527615, 32296183, 33323470, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10759893
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IDA	11897662, 20545304
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IDA	11897662
GO:0006334	Process	Nucleosome assembly	IDA	14718166
GO:0006334	Process	Nucleosome assembly	IEA
GO:0006335	Process	DNA replication-dependent chromatin assembly	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0031297	Process	Replication fork processing	IDA	18417535, 27338793, 27797818, 29478807
GO:0031297	Process	Replication fork processing	IDA	29478807
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0035861	Component	Site of double-strand break	IDA	29478807
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	10759893
GO:0042692	Process	Muscle cell differentiation	IEA
GO:0071168	Process	Protein localization to chromatin	IDA	27338793, 27797818
GO:0140713	Function	Histone chaperone activity	IDA	10759893, 29478807
GO:0140713	Function	Histone chaperone activity	IEA
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IDA	29478807

MIM	HGNC	e!Ensembl
609189	20995	ENSG00000111875

Q9Y294

Protein name

Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)

Protein function

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454

PDB

1TEY , 2I32 , 2IIJ , 2IO5 , 3AAD , 5C3I , 6F0F , 6F0G , 6F0H , 6ZUF , 7LNY , 7LO0 , 7V6Q , 8BV1 , 8CJ1 , 8CJ2 , 8CJ3 , 8Z50

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04729	ASF1_hist_chap	1 → 154	ASF1 like histone chaperone	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12842904}.

Sequence

MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSV
LVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTET
ELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALP
SASKGWSTSENSLNVMLESHMDCM

Sequence length

204

Interactions

View interactions

	Reactome
			Formation of Senescence-Associated Heterochromatin Foci (SAHF)

ASF1A (anti-silencing function 1A histone chaperone)