KLK5 (kallikrein related peptidase 5)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25818
Gene name Gene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLK5
Synonyms (NCBI Gene) Gene synonyms aliases
KLK-L2, KLKL2, SCTE
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
Summary Summary of gene provided in NCBI Entrez Gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0002803 Process Positive regulation of antibacterial peptide production IBA 21873635
GO:0002803 Process Positive regulation of antibacterial peptide production IMP 17012259
GO:0004252 Function Serine-type endopeptidase activity EXP 16885167
GO:0004252 Function Serine-type endopeptidase activity IDA 16885167
GO:0004252 Function Serine-type endopeptidase activity NAS 11054574
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605643 6366 ENSG00000167754
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y337
Protein name Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)
Protein function May be involved in desquamation.
PDB 2PSX , 2PSY , 6QFE , 7U5B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 67 → 285 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin. {ECO:0000269|PubMed:19190773}.
Sequence
Sequence length 293
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16517595
Show/Hide Text Mining Associations (38)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30755669
Adenoma Pleomorphic Associate 30120721
Ascites Associate 16557045
Asthma Associate 35487308
Breast Neoplasms Associate 10608802, 15361712, 17656355, 23086576
Breast Neoplasms Inhibit 14710225, 19453546
Breast Neoplasms Stimulate 18804527
Carcinoma Renal Cell Associate 16340244
Cardiotoxicity Associate 35879248
Colorectal Neoplasms Associate 19367279