TAFA5 (TAFA chemokine like family member 5)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25817
Gene name Gene Name - the full gene name approved by the HGNC.
TAFA chemokine like family member 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAFA5
Synonyms (NCBI Gene) Gene synonyms aliases
FAM19A5, QLLK5208, TAFA-5, UNQ5208
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005615 Component Extracellular space IEA
GO:0007165 Process Signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617499 21592 ENSG00000219438
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q7Z5A7
Protein name Chemokine-like protein TAFA-5
Protein function Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12020 TAFA 42 → 131 TAFA family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the subcutaneous and perirenal adipose tissue (at protein level) (PubMed:29453251). Highly expressed in adipose tissue with moderate expression in the brain and ovary (PubMed:29453251). Isoform 2: Brain-specific (PubMed:15
Sequence
Sequence length 132
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Pancreatic cancer Malignant neoplasm of pancreas rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431 22158540
Show/Hide Unknown Diseases (6)
Unknown
Disease term Disease name Evidence References Source
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Cholangiocarcinoma Associate 26060332
Cognition Disorders Associate 32831973
Colorectal Neoplasms Associate 39199384
Dementia Vascular Associate 32831973
Diabetes Mellitus Type 2 Stimulate 31280604
Heredodegenerative Disorders Nervous System Associate 32831973
Hyperuricemia Associate 26722554
Metabolic Diseases Associate 31280604
Neoplasm Metastasis Stimulate 31702029
Neoplasms Associate 31702029