Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25814
Gene name Gene Name - the full gene name approved by the HGNC.	Ataxin 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ATXN10
Synonyms (NCBI Gene) Gene synonyms aliases	ATX10, E46L, HUMEEP, SCA10
Disease Acronyms (UniProt) Disease acronyms from UniProt database	SCA10
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 8

Show/Hide all(264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020830	hsa-miR-155-5p	Proteomics	18668040
MIRT028592	hsa-miR-30a-5p	Proteomics	18668040
MIRT046248	hsa-miR-23b-3p	CLASH	23622248
MIRT158763	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT158763	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT810634	hsa-miR-1208	CLIP-seq
MIRT810635	hsa-miR-127-5p	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT810640	hsa-miR-3156-3p	CLIP-seq
MIRT810641	hsa-miR-320e	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810643	hsa-miR-4301	CLIP-seq
MIRT810644	hsa-miR-4475	CLIP-seq
MIRT810645	hsa-miR-452	CLIP-seq
MIRT810646	hsa-miR-4668-5p	CLIP-seq
MIRT810647	hsa-miR-4676-3p	CLIP-seq
MIRT810648	hsa-miR-4686	CLIP-seq
MIRT810649	hsa-miR-4731-5p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810651	hsa-miR-532-3p	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810653	hsa-miR-626	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT810654	hsa-miR-155	CLIP-seq
MIRT810655	hsa-miR-190	CLIP-seq
MIRT810656	hsa-miR-190b	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT810657	hsa-miR-2278	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT810658	hsa-miR-3140-3p	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810660	hsa-miR-340	CLIP-seq
MIRT810661	hsa-miR-34b	CLIP-seq
MIRT810662	hsa-miR-3617	CLIP-seq
MIRT810663	hsa-miR-3682-3p	CLIP-seq
MIRT810664	hsa-miR-3925-5p	CLIP-seq
MIRT810665	hsa-miR-4276	CLIP-seq
MIRT810666	hsa-miR-4468	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT810668	hsa-miR-450b-5p	CLIP-seq
MIRT810669	hsa-miR-4678	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT810648	hsa-miR-4686	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810672	hsa-miR-4795-3p	CLIP-seq
MIRT810673	hsa-miR-4803	CLIP-seq
MIRT810674	hsa-miR-507	CLIP-seq
MIRT810675	hsa-miR-518a-5p	CLIP-seq
MIRT810676	hsa-miR-527	CLIP-seq
MIRT810677	hsa-miR-539	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT810679	hsa-miR-557	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT810653	hsa-miR-626	CLIP-seq
MIRT810681	hsa-miR-641	CLIP-seq
MIRT810682	hsa-miR-653	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT1545634	hsa-miR-297	CLIP-seq
MIRT1545635	hsa-miR-3149	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT1545636	hsa-miR-567	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT1939609	hsa-miR-2052	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT1545634	hsa-miR-297	CLIP-seq
MIRT1545635	hsa-miR-3149	CLIP-seq
MIRT1939610	hsa-miR-3202	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810660	hsa-miR-340	CLIP-seq
MIRT1939611	hsa-miR-421	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT1939612	hsa-miR-4533	CLIP-seq
MIRT1939613	hsa-miR-4650-3p	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT1545636	hsa-miR-567	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT810654	hsa-miR-155	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT2178843	hsa-miR-23a	CLIP-seq
MIRT2178844	hsa-miR-23b	CLIP-seq
MIRT2178845	hsa-miR-23c	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810660	hsa-miR-340	CLIP-seq
MIRT810664	hsa-miR-3925-5p	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT1939613	hsa-miR-4650-3p	CLIP-seq
MIRT2178846	hsa-miR-4668-3p	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT810648	hsa-miR-4686	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810672	hsa-miR-4795-3p	CLIP-seq
MIRT810675	hsa-miR-518a-5p	CLIP-seq
MIRT810676	hsa-miR-527	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT2178847	hsa-miR-548c-3p	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT810653	hsa-miR-626	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810654	hsa-miR-155	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT2482395	hsa-miR-1321	CLIP-seq
MIRT2482396	hsa-miR-1343	CLIP-seq
MIRT810654	hsa-miR-155	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT2178843	hsa-miR-23a	CLIP-seq
MIRT2178844	hsa-miR-23b	CLIP-seq
MIRT2178845	hsa-miR-23c	CLIP-seq
MIRT2482397	hsa-miR-24	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT1545634	hsa-miR-297	CLIP-seq
MIRT1545635	hsa-miR-3149	CLIP-seq
MIRT2482398	hsa-miR-3158-3p	CLIP-seq
MIRT2482399	hsa-miR-3192	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810660	hsa-miR-340	CLIP-seq
MIRT2482400	hsa-miR-3545-3p	CLIP-seq
MIRT2482401	hsa-miR-3618	CLIP-seq
MIRT2482402	hsa-miR-3646	CLIP-seq
MIRT2482403	hsa-miR-3662	CLIP-seq
MIRT2482404	hsa-miR-3682-5p	CLIP-seq
MIRT810664	hsa-miR-3925-5p	CLIP-seq
MIRT810665	hsa-miR-4276	CLIP-seq
MIRT2482405	hsa-miR-4314	CLIP-seq
MIRT2482406	hsa-miR-4419a	CLIP-seq
MIRT2482407	hsa-miR-4437	CLIP-seq
MIRT2482408	hsa-miR-4446-3p	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT2482409	hsa-miR-4506	CLIP-seq
MIRT2482410	hsa-miR-4510	CLIP-seq
MIRT2482411	hsa-miR-4646-5p	CLIP-seq
MIRT1939613	hsa-miR-4650-3p	CLIP-seq
MIRT2178846	hsa-miR-4668-3p	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT2482412	hsa-miR-4690-3p	CLIP-seq
MIRT2482413	hsa-miR-4698	CLIP-seq
MIRT2482414	hsa-miR-4709-3p	CLIP-seq
MIRT2482415	hsa-miR-4712-5p	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT2482416	hsa-miR-4728-5p	CLIP-seq
MIRT2482417	hsa-miR-4739	CLIP-seq
MIRT2482418	hsa-miR-4756-5p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT2482419	hsa-miR-494	CLIP-seq
MIRT2482420	hsa-miR-516a-5p	CLIP-seq
MIRT810675	hsa-miR-518a-5p	CLIP-seq
MIRT810676	hsa-miR-527	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT2178847	hsa-miR-548c-3p	CLIP-seq
MIRT1545636	hsa-miR-567	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT2482421	hsa-miR-642b	CLIP-seq
MIRT2482422	hsa-miR-770-5p	CLIP-seq
MIRT2482423	hsa-miR-934	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq
MIRT810636	hsa-miR-128	CLIP-seq
MIRT2482395	hsa-miR-1321	CLIP-seq
MIRT2482396	hsa-miR-1343	CLIP-seq
MIRT810654	hsa-miR-155	CLIP-seq
MIRT810637	hsa-miR-21	CLIP-seq
MIRT2178843	hsa-miR-23a	CLIP-seq
MIRT2178844	hsa-miR-23b	CLIP-seq
MIRT2178845	hsa-miR-23c	CLIP-seq
MIRT2482397	hsa-miR-24	CLIP-seq
MIRT810638	hsa-miR-27a	CLIP-seq
MIRT810639	hsa-miR-27b	CLIP-seq
MIRT2675776	hsa-miR-296-3p	CLIP-seq
MIRT1545634	hsa-miR-297	CLIP-seq
MIRT2675777	hsa-miR-3064-3p	CLIP-seq
MIRT1545635	hsa-miR-3149	CLIP-seq
MIRT2482398	hsa-miR-3158-3p	CLIP-seq
MIRT2482399	hsa-miR-3192	CLIP-seq
MIRT810659	hsa-miR-323-3p	CLIP-seq
MIRT810642	hsa-miR-338-5p	CLIP-seq
MIRT810660	hsa-miR-340	CLIP-seq
MIRT2482400	hsa-miR-3545-3p	CLIP-seq
MIRT2482401	hsa-miR-3618	CLIP-seq
MIRT2482402	hsa-miR-3646	CLIP-seq
MIRT2482403	hsa-miR-3662	CLIP-seq
MIRT2675778	hsa-miR-3671	CLIP-seq
MIRT2482404	hsa-miR-3682-5p	CLIP-seq
MIRT2675779	hsa-miR-3691-3p	CLIP-seq
MIRT810664	hsa-miR-3925-5p	CLIP-seq
MIRT810665	hsa-miR-4276	CLIP-seq
MIRT2482405	hsa-miR-4314	CLIP-seq
MIRT2482406	hsa-miR-4419a	CLIP-seq
MIRT2482407	hsa-miR-4437	CLIP-seq
MIRT2482408	hsa-miR-4446-3p	CLIP-seq
MIRT810667	hsa-miR-4470	CLIP-seq
MIRT2675780	hsa-miR-4504	CLIP-seq
MIRT2482409	hsa-miR-4506	CLIP-seq
MIRT2482410	hsa-miR-4510	CLIP-seq
MIRT2482411	hsa-miR-4646-5p	CLIP-seq
MIRT1939613	hsa-miR-4650-3p	CLIP-seq
MIRT2178846	hsa-miR-4668-3p	CLIP-seq
MIRT810670	hsa-miR-4685-5p	CLIP-seq
MIRT2482412	hsa-miR-4690-3p	CLIP-seq
MIRT2482413	hsa-miR-4698	CLIP-seq
MIRT2482414	hsa-miR-4709-3p	CLIP-seq
MIRT2482415	hsa-miR-4712-5p	CLIP-seq
MIRT810671	hsa-miR-4716-3p	CLIP-seq
MIRT2482416	hsa-miR-4728-5p	CLIP-seq
MIRT2482417	hsa-miR-4739	CLIP-seq
MIRT2482418	hsa-miR-4756-5p	CLIP-seq
MIRT810650	hsa-miR-4789-5p	CLIP-seq
MIRT810675	hsa-miR-518a-5p	CLIP-seq
MIRT810676	hsa-miR-527	CLIP-seq
MIRT810678	hsa-miR-548an	CLIP-seq
MIRT2178847	hsa-miR-548c-3p	CLIP-seq
MIRT1545636	hsa-miR-567	CLIP-seq
MIRT810652	hsa-miR-590-5p	CLIP-seq
MIRT810680	hsa-miR-618	CLIP-seq
MIRT2482421	hsa-miR-642b	CLIP-seq
MIRT2482422	hsa-miR-770-5p	CLIP-seq
MIRT2482423	hsa-miR-934	CLIP-seq
MIRT810683	hsa-miR-935	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16498633, 21565611, 26496610, 32814053
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005737	Component	Cytoplasm	IDA	15201271
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0007399	Process	Nervous system development	IMP	16385455
GO:0016020	Component	Membrane	HDA	19946888
GO:0019899	Function	Enzyme binding	IEA
GO:0030425	Component	Dendrite	IDA	15201271
GO:0031175	Process	Neuron projection development	IBA	21873635
GO:0031175	Process	Neuron projection development	IDA	16498633
GO:0042802	Function	Identical protein binding	IEA
GO:0043025	Component	Neuronal cell body	IDA	15201271
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15201271, 16498633
GO:0060271	Process	Cilium assembly	IEA

MIM	HGNC	e!Ensembl
611150	10549	ENSG00000130638

Protein

UniProt ID

Q9UBB4

Protein name

Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)

Protein function

May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the surv

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09759	Atx10homo_assoc	370 → 467	Spinocerebellar ataxia type 10 protein domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the central nervous system. {ECO:0000269|PubMed:15201271}.

Sequence

MAAPRPPPARLSGVMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSSHA
VELACRDPSQVENLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLILLFRE
LRVEQESLLTAFRCGLQFLGNIASRNEDSQSIVWVHAFPELFLSCLNHPDKKIVAYSSMI
LFTSLNHERMKELEENLNIAIDVIDAYQKHPESEWPFLIITDLFLKSPELVQAMFPKLNN
QERVTLLDLMIAKITSDEPLTKDDIPVFLRHAELIASTFVDQCKTVLKLASEEPPDDEEA
LATIRLLDVLCEMTVNTELLGYLQVFPGLLERVIDLLRVIHVAGKETTNIFSNCGCVRAE
GDISNVANGFKSHLIRLIGNLCYKNKDNQDKVNELDGIPLILDNCNISDSNPFLTQWVIY
AIRNLTEDNSQNQDLIAKMEEQGLADASLLKKVGFEVEKKGEKLILKSTRDTPKP

Sequence length

475

Interactions

View interactions

	KEGG
	Spinocerebellar ataxia

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Cerebellar ataxia	Progressive cerebellar ataxia	rs28936415, rs199476133, rs540331226, rs797046006, rs863224069, rs138358708, rs1057519429, rs750959420, rs1568440440, rs1597846084, rs759460806, rs761486324, rs1240335250, rs1596489887
Epilepsy	Epilepsy, Partial, Motor	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)
Nephronophthisis	Nephronophthisis	rs62635288, rs267607116, rs201893408, rs267607117, rs202149403, rs118204032, rs121918244, rs750962965, rs1474058708, rs119456959, rs119456960, rs119456961, rs119456962, rs267606916, rs137852856 View all (190 more)	21565611
Nystagmus	Nystagmus, Nystagmus, End-Position	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Seizure	Complex partial seizures, Generalized seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061 View all (179 more)
Spinocerebellar ataxia	Spinocerebellar Ataxia 10, Spinocerebellar ataxia type 10	rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926 View all (203 more)	17620556

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Mental depression	Depressive disorder		ClinVar
Diabetes	Diabetes		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining
Apraxia oculomotor Cogan type	Associate	25630585
Ataxia	Associate	9973298
Atherosclerosis	Associate	34858081
Colorectal Neoplasms	Associate	35247911
Communicable Diseases	Associate	31061469
Epilepsy	Associate	24935856
Friedreich Ataxia	Associate	15096564
Glioma	Associate	40214613
Immunoglobulin G4 Related Disease	Stimulate	32745980
Inflammation	Inhibit	34858081
Meningococcal Infections	Associate	31061469
Neuromuscular Diseases	Associate	24269018
Seizures	Associate	25630585
Spinocerebellar Ataxia 10	Associate	15970586, 19234597, 20548952, 21282659, 24278426, 24318420, 24935856, 25666058, 26039897, 28423040, 28542277, 32520333
Spinocerebellar Ataxia 10	Stimulate	17846122
Spinocerebellar Ataxias	Associate	33502644
Spinocerebellar Degenerations	Associate	26374734
Vascular Diseases	Associate	34858081

ATXN10 (ataxin 10)