Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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257397
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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TGF-beta activated kinase 1 (MAP3K7) binding protein 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TAB3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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MAP3K7IP3, NAP1 |
Chromosome
Chromosome number
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X |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
Xp21.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 |
UniProt ID |
Q8N5C8
|
Protein name |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) |
Protein function |
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:14633987, PubMed:14766965, PubMed:15327770, PubMed:22158 |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02845
|
CUE |
9 → 50 |
CUE domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Widely expressed. Constitutively overexpressed in certain tumor tissues. {ECO:0000269|PubMed:14670075}.; TISSUE SPECIFICITY: [Isoform 1]: Major transcript. {ECO:0000269|PubMed:14766965}.; TISSUE SPECIFICITY: [Isoform 2]: Minor transcri |
Sequence |
MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHS PDDNRMNRNRLLHINLGIHSPSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICL VQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPP PPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIYIRQTSQSSS GRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSAYHSPPPSQC PSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGPPSYQKQGSHSVAYLPYTASSLSK GSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKP PFSVNPVYITYTQPTGPSCTPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAP EPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEEL ERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQINVDCTLKEVDLLQS RGNFDPKAMNNFYDNIEPGPVVPPKPSKKDSSDPCTIERKARRISVTSKVQADIHDTQAA AADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
|
|
Sequence length |
712 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Common variable immunodeficiency |
Common Variable Immunodeficiency |
rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113, rs1553319504, rs201017642, rs1555550717, rs1558192723, rs1030733127, rs749636258, rs185689791, rs1559035937, rs1565214594, rs1560679469, rs1560711146, rs1569376229, rs1578790573, rs939459600, rs1572952530, rs1572950925, rs772481080, rs369363360, rs72553885, rs72553879, rs1265262160, rs1303637368, rs757598952, rs1016142312, rs1578771120, rs1578771197, rs1578793298, rs1578793312, rs1578809101, rs1578811073, rs1590715754, rs144718007, rs759649059, rs1723945421, rs2061279365 View all (35 more) |
21497890 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Prostate cancer |
Prostate cancer |
Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. |
|
GWAS, CBGDA |
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Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Carcinogenesis |
Associate
|
37203408 |
Carcinoma Hepatocellular |
Associate
|
24565101, 26875893 |
Carcinoma Non Small Cell Lung |
Stimulate
|
26476534 |
Gonadal Dysgenesis 46 XY |
Associate
|
36613932 |
Inflammation |
Associate
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17449468, 24942571 |
Lung Neoplasms |
Associate
|
26476534 |
Ovarian Neoplasms |
Inhibit
|
27651027 |
Uterine Cervical Neoplasms |
Associate
|
37203408 |
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