Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2568
Gene name	Gamma-aminobutyric acid type A receptor subunit pi
Gene symbol	GABRP
Synonyms (NCBI Gene)	-
Chromosome	5
Chromosome location	5q35.1
Summary	The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues includ

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016992	hsa-miR-335-5p	Microarray	18185580
MIRT1010125	hsa-miR-125a-3p	CLIP-seq
MIRT1010126	hsa-miR-145	CLIP-seq
MIRT1010127	hsa-miR-146a	CLIP-seq
MIRT1010128	hsa-miR-146b-5p	CLIP-seq
MIRT1010129	hsa-miR-2110	CLIP-seq
MIRT1010130	hsa-miR-299-3p	CLIP-seq
MIRT1010131	hsa-miR-29a	CLIP-seq
MIRT1010132	hsa-miR-29b	CLIP-seq
MIRT1010133	hsa-miR-29c	CLIP-seq
MIRT1010134	hsa-miR-3153	CLIP-seq
MIRT1010135	hsa-miR-3667-3p	CLIP-seq
MIRT1010136	hsa-miR-3671	CLIP-seq
MIRT1010137	hsa-miR-3675-5p	CLIP-seq
MIRT1010138	hsa-miR-376a	CLIP-seq
MIRT1010139	hsa-miR-376b	CLIP-seq
MIRT1010140	hsa-miR-3934	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010142	hsa-miR-4270	CLIP-seq
MIRT1010143	hsa-miR-4271	CLIP-seq
MIRT1010144	hsa-miR-4432	CLIP-seq
MIRT1010145	hsa-miR-4441	CLIP-seq
MIRT1010146	hsa-miR-4468	CLIP-seq
MIRT1010147	hsa-miR-4506	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010150	hsa-miR-4668-5p	CLIP-seq
MIRT1010151	hsa-miR-4712-5p	CLIP-seq
MIRT1010152	hsa-miR-4725-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010154	hsa-miR-4764-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010156	hsa-miR-548u	CLIP-seq
MIRT1010157	hsa-miR-589	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010159	hsa-miR-649	CLIP-seq
MIRT1010160	hsa-miR-656	CLIP-seq
MIRT1010161	hsa-miR-759	CLIP-seq
MIRT1010162	hsa-miR-764	CLIP-seq
MIRT1010163	hsa-miR-767-5p	CLIP-seq
MIRT1010164	hsa-miR-770-5p	CLIP-seq
MIRT1010165	hsa-miR-888	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT2232884	hsa-miR-4773	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq
MIRT1010141	hsa-miR-412	CLIP-seq
MIRT1010148	hsa-miR-4659a-3p	CLIP-seq
MIRT1010149	hsa-miR-4659b-3p	CLIP-seq
MIRT1010153	hsa-miR-4735-5p	CLIP-seq
MIRT1010155	hsa-miR-4775	CLIP-seq
MIRT1010158	hsa-miR-590-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	IBA
GO:0004890	Function	GABA-A receptor activity	IDA	10462548
GO:0004890	Function	GABA-A receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	IEA
GO:0004890	Function	GABA-A receptor activity	TAS	9182563
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0022851	Function	GABA-gated chloride ion channel activity	IDA	10462548
GO:0022851	Function	GABA-gated chloride ion channel activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0051932	Process	Synaptic transmission, GABAergic	IBA
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902711	Component	GABA-A receptor complex	IBA

MIM	HGNC	e!Ensembl
602729	4089	ENSG00000094755

O00591

Protein name

Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) (GABAAR subunit pi)

Protein function

Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central p

PDB

8VSZ , 8VV0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02931	Neur_chan_LBD	40 → 242	Neurotransmitter-gated ion-channel ligand binding domain	Family
PF02932	Neur_chan_memb	249 → 365	Neurotransmitter-gated ion-channel transmembrane region	Family

Tissue specificity

TISSUE SPECIFICITY: Most abundant in non-neuronal tissues including the uterus, ovaries and also expressed in lung, thymus and prostate (PubMed:10462548, PubMed:9182563). Expressed in the hippocampus (PubMed:10462548). {ECO:0000269|PubMed:10462548, ECO:00

Sequence

MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEP
VQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDT
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
WGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRR
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSIS
SFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKL
LFPLIFMLANVFYWAYYMYF

Sequence length

440

Interactions

View interactions

	KEGG
	Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Morphine addiction Nicotine addiction

GABRP (gamma-aminobutyric acid type A receptor subunit pi)