Gene Gene information from NCBI Gene database.
Entrez ID 253943
Gene name YTH N6-methyladenosine RNA binding protein F3
Gene symbol YTHDF3
Synonyms (NCBI Gene)
DF3
Chromosome 8
Chromosome location 8q12.3
Summary This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple tran
miRNA miRNA information provided by mirtarbase database.
670
miRTarBase ID miRNA Experiments Reference
MIRT720076 hsa-miR-137 HITS-CLIP 19536157
MIRT720075 hsa-miR-6865-3p HITS-CLIP 19536157
MIRT720074 hsa-miR-3620-3p HITS-CLIP 19536157
MIRT720073 hsa-miR-6802-3p HITS-CLIP 19536157
MIRT720071 hsa-miR-5096 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IDA 32492408
GO:0000932 Component P-body IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0003723 Function RNA binding IDA 32194978
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618669 26465 ENSG00000185728
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z739
Protein name YTH domain-containing family protein 3 (DF3)
Protein function Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability (PubMed:28106072, PubMed:28106076, PubMed:28281539, PubMed:32492408). M6A is a modification present at internal sites of mRNAs and some non
PDB 6ZOT , 8BS5 , 8BS6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04146 YTH 416 491 YT521-B-like domain Domain
PF04146 YTH 488 551 YT521-B-like domain Domain
Sequence
MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSY
YAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLG
QHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSK
VPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAA
IARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTI
IQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNR
GAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFI
IKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMK
SVVDYNA
YAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPL
EKAKQVLKIIA
TFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
Sequence length 585
Interactions View interactions