Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
253558
Gene name Gene Name - the full gene name approved by the HGNC.
Lysocardiolipin acyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LCLAT1
Synonyms (NCBI Gene) Gene synonyms aliases
1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LPLAT6, LYCAT, UNQ1849
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p23.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005252 hsa-miR-155-5p pSILAC 18668040
MIRT005252 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023154 hsa-miR-124-3p Microarray 18668037
MIRT025101 hsa-miR-181a-5p Sequencing 20371350
MIRT028546 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IDA 16620771, 19075029
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005783 Component Endoplasmic reticulum IDA 16620771, 19075029
GO:0005789 Component Endoplasmic reticulum membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614241 26756 ENSG00000172954
Protein
UniProt ID Q6UWP7
Protein name Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)
Protein function Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as subs
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 103 262 Acyltransferase Family
PF16076 Acyltransf_C 271 347 Acyltransferase C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Sequence
MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSI
FMLSPFLPLMFVNPSWYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVII
MNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKS
HFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTF
VVDRLREGKNLDAVHDITVAYP
HNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDL
QLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKL
LSILYWTLFSPAM
CLLIYLYSLVKWYFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE
Sequence length 414
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
  Acyl chain remodeling of CL
Synthesis of PA
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Eczema Eczema GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 25997986
Carcinoma Hepatocellular Associate 36845084
Ovarian Diseases Associate 37393390
Squamous Cell Carcinoma of Head and Neck Associate 33456371
Tetralogy of Fallot Inhibit 23571024
Ventricular Remodeling Associate 23571024