Gene Gene information from NCBI Gene database.
Entrez ID 253558
Gene name Lysocardiolipin acyltransferase 1
Gene symbol LCLAT1
Synonyms (NCBI Gene)
1AGPAT8AGPAT8ALCAT1HSRG1849LPLAT6LYCATUNQ1849
Chromosome 2
Chromosome location 2p23.1
miRNA miRNA information provided by mirtarbase database.
872
miRTarBase ID miRNA Experiments Reference
MIRT005252 hsa-miR-155-5p pSILAC 18668040
MIRT005252 hsa-miR-155-5p Proteomics;Other 18668040
MIRT023154 hsa-miR-124-3p Microarray 18668037
MIRT025101 hsa-miR-181a-5p Sequencing 20371350
MIRT028546 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IDA 16620771, 19075029
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005783 Component Endoplasmic reticulum IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614241 26756 ENSG00000172954
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6UWP7
Protein name Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)
Protein function Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as subs
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 103 262 Acyltransferase Family
PF16076 Acyltransf_C 271 347 Acyltransferase C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. {ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
Sequence
MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSI
FMLSPFLPLMFVNPSWYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVII
MNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKS
HFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTF
VVDRLREGKNLDAVHDITVAYP
HNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDL
QLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKL
LSILYWTLFSPAM
CLLIYLYSLVKWYFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE
Sequence length 414
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
  Acyl chain remodeling of CL
Synthesis of PA