Gene Gene information from NCBI Gene database.
Entrez ID 253260
Gene name RPTOR independent companion of MTOR complex 2
Gene symbol RICTOR
Synonyms (NCBI Gene)
AVO3PIAhAVO3
Chromosome 5
Chromosome location 5p13.1
Summary RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs1554059320 T>- Likely-pathogenic Coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
756
miRTarBase ID miRNA Experiments Reference
MIRT006105 hsa-miR-218-5p Luciferase reporter assayqRT-PCRWestern blot 21795477
MIRT006105 hsa-miR-218-5p Luciferase reporter assayqRT-PCRWestern blot 21795477
MIRT006105 hsa-miR-218-5p Luciferase reporter assayqRT-PCRWestern blot 21795477
MIRT006105 hsa-miR-218-5p Luciferase reporter assayqRT-PCRWestern blot 21795477
MIRT006105 hsa-miR-218-5p Luciferase reporter assayqRT-PCRWestern blot 21795477
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
58
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0005515 Function Protein binding IPI 15467718, 15778465, 17461779, 17565979, 18339839, 18566587, 19446321, 19720745, 19875983, 19935711, 21045808, 21339740, 21376236, 21964062, 22307628, 23263282, 23953116, 24036451, 24375676, 25241761, 25897075, 27043084, 28514442, 29567957, 30232230, 32647003, 33378666, 33961781, 352
GO:0005524 Function ATP binding IDA 33158864
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609022 28611 ENSG00000164327
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6R327
Protein name Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
Protein function Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470
PDB 5ZCS , 6ZWM , 6ZWO , 7PE7 , 7PE8 , 7PE9 , 7TZO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14664 RICTOR_N 57 439 Rapamycin-insensitive companion of mTOR, N-term Domain
PF14666 RICTOR_M 637 740 Rapamycin-insensitive companion of mTOR, middle domain Domain
PF14663 RasGEF_N_2 746 853 Rapamycin-insensitive companion of mTOR RasGEF_N domain Domain
PF14668 RICTOR_V 921 991 Rapamycin-insensitive companion of mTOR, domain 5 Domain
PF14665 RICTOR_phospho 1084 1188 Rapamycin-insensitive companion of mTOR, phosphorylation-site Domain
Sequence
MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHL
NNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKV
LKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQER
DRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKT
RQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIIN
LCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQD
SWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHIS
VRATILLGELLHMANTILP
HSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFH
EMKKRGPKPYSLHLDHIIQKAIATHQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQH
KENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQ
LTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYF
LFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKI
LTAATDACRLYATKHLRVLL
RANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACED
KANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYV
DLIEEQLNEALTT
YRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQN
IITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCE
VLSIRGTCVYVLGLIAKTKQGCDILKCHNWD
AVRHSRKHLWPVVPDDVEQLCNELSSIPS
TLSLNSESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIK
DKNSFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVD
FNHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKN
FGTENHRENTSR
ERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVS
TKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFS
YTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRF
MKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVK
DIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDA
SLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIH
NPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLV
INLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV
QFLQMHEEAEAVLATPPKQPIVDTSAES
Sequence length 1708
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  mTOR signaling pathway   PIP3 activates AKT signaling
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Premature ovarian failure Likely pathogenic rs1329438711 RCV001270199
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Uncertain significance rs61748206 RCV005926872
Gastric cancer Uncertain significance rs61748206 RCV005926873
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27151654
Astrocytoma Associate 27789731
Breast Neoplasms Associate 24479521, 26336805, 27184734, 40403210
Breast Neoplasms Inhibit 27525949
Calcinosis Cutis Stimulate 35392503
Carcinoma Hepatocellular Associate 24312415, 33061800, 35187863
Carcinoma Merkel Cell Associate 26981779
Carcinoma Non Small Cell Lung Associate 26176608, 35982899, 37569873
Carcinoma Pancreatic Ductal Associate 28445935
Carcinoma Renal Cell Associate 26500094, 37298315