Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
253260
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
RPTOR independent companion of MTOR complex 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
RICTOR |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
AVO3, PIA, hAVO3 |
Chromosome
Chromosome number
|
5 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5p13.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
UniProt ID |
Q6R327
|
Protein name |
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) |
Protein function |
Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:15268862, PubMed:15718470 |
PDB |
5ZCS
,
6ZWM
,
6ZWO
,
7PE7
,
7PE8
,
7PE9
,
7TZO
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF14664
|
RICTOR_N |
57 → 439 |
Rapamycin-insensitive companion of mTOR, N-term |
Domain |
PF14666
|
RICTOR_M |
637 → 740 |
Rapamycin-insensitive companion of mTOR, middle domain |
Domain |
PF14663
|
RasGEF_N_2 |
746 → 853 |
Rapamycin-insensitive companion of mTOR RasGEF_N domain |
Domain |
PF14668
|
RICTOR_V |
921 → 991 |
Rapamycin-insensitive companion of mTOR, domain 5 |
Domain |
PF14665
|
RICTOR_phospho |
1084 → 1188 |
Rapamycin-insensitive companion of mTOR, phosphorylation-site |
Domain |
|
Sequence |
|
Sequence length |
1708 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
|
Lung carcinoma |
Carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
|
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Glioblastoma |
Glioblastoma |
CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 |
|
GWAS, CBGDA |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
27151654 |
Astrocytoma |
Associate
|
27789731 |
Breast Neoplasms |
Associate
|
24479521, 26336805, 27184734, 40403210 |
Breast Neoplasms |
Inhibit
|
27525949 |
Calcinosis Cutis |
Stimulate
|
35392503 |
Carcinoma Hepatocellular |
Associate
|
24312415, 33061800, 35187863 |
Carcinoma Merkel Cell |
Associate
|
26981779 |
Carcinoma Non Small Cell Lung |
Associate
|
26176608, 35982899, 37569873 |
Carcinoma Pancreatic Ductal |
Associate
|
28445935 |
Carcinoma Renal Cell |
Associate
|
26500094, 37298315 |
Carcinoma Small Cell |
Associate
|
28028034 |
Cholangiocarcinoma |
Associate
|
38186315 |
Colonic Neoplasms |
Associate
|
29882195, 37372460 |
Colorectal Neoplasms |
Associate
|
21430067, 22285861, 24244675, 28028034, 38186315 |
Desmoplastic Small Round Cell Tumor |
Associate
|
23922674 |
Endometrial Neoplasms |
Associate
|
24966915 |
Gallbladder Neoplasms |
Associate
|
24508317 |
Gastrointestinal Neoplasms |
Associate
|
20116405, 38186315 |
GATA2 Deficiency |
Associate
|
25907832 |
Glioblastoma |
Associate
|
27789731 |
Glioma |
Associate
|
25761241, 27789731, 31187466 |
Hypersensitivity Immediate |
Stimulate
|
27789731 |
Hypoxia |
Associate
|
28445935 |
Impotence Vasculogenic |
Associate
|
28699701 |
Kidney Neoplasms |
Associate
|
25016284 |
Leiomyosarcoma |
Stimulate
|
22080063 |
Lung Neoplasms |
Associate
|
28028034 |
Lymphatic Metastasis |
Associate
|
24966915 |
Lymphoma Large B Cell Diffuse |
Associate
|
22899290 |
Melanoma |
Associate
|
28699701, 38615585 |
Mesothelioma Malignant |
Associate
|
20839315 |
Multiple Myeloma |
Associate
|
37499483 |
Nasopharyngeal Carcinoma |
Inhibit
|
27525949 |
Neoplasm Metastasis |
Stimulate
|
21430067 |
Neoplasm Metastasis |
Associate
|
26500094, 35982899 |
Neoplasms |
Associate
|
18831768, 24244675, 25122428, 25918246, 27151654, 27184734, 28028034, 28122379, 28445935, 28699701, 28776571, 32588907, 33416177, 35187863, 37949943, 38186315 View all (1 more) |
Neoplasms |
Stimulate
|
37372460 |
Oculocutaneous albinism type 2 |
Stimulate
|
27789731 |
Ovarian Neoplasms |
Associate
|
24086535, 27211906, 34126157 |
Pancreatic Neoplasms |
Associate
|
28445935 |
Prostatic Neoplasms |
Associate
|
23272152, 23646189, 24244675, 31995655, 36388085 |
Respiratory System Abnormalities |
Associate
|
38186315 |
Sarcoma |
Associate
|
28028034 |
Small Cell Lung Carcinoma |
Associate
|
24978188, 27863413, 32584426, 38233864, 38237798 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
31393061, 37372460 |
Squamous Cell Carcinoma of Head and Neck |
Stimulate
|
33482765 |
Stomach Diseases |
Associate
|
28028034 |
Stomach Neoplasms |
Associate
|
28028034, 32588907 |
Thrombocytopenia Neonatal Alloimmune |
Associate
|
1932744 |
Tongue Neoplasms |
Associate
|
25749387 |
Urinary Bladder Neoplasms |
Associate
|
24312263 |
Uterine Cervical Neoplasms |
Associate
|
25945419 |
Uterine Cervical Neoplasms |
Inhibit
|
27525949 |
|