Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways
Entrez ID	251
Gene name	Alkaline phosphatase, germ cell
Gene symbol	ALPG
Synonyms (NCBI Gene)	ALPPLALPPL2GCAP
Chromosome	2
Chromosome location	2q37.1
Summary	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certa

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004035	Function	Alkaline phosphatase activity	IBA
GO:0004035	Function	Alkaline phosphatase activity	IDA	1939159
GO:0004035	Function	Alkaline phosphatase activity	IEA
GO:0004035	Function	Alkaline phosphatase activity	NAS	2162249
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0098552	Component	Side of membrane	IEA

MIM	HGNC	e!Ensembl
171810	441	ENSG00000163286

P10696

Protein name

Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)

Protein function

Alkaline phosphatase that can hydrolyze various phosphate compounds.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00245	Alk_phosphatase	52 → 487	Alkaline phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Trace amounts in the testis and thymus, and in elevated amounts in germ cell tumors.

Sequence

MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

Sequence length

532

Interactions

View interactions

	KEGG		Reactome
	Thiamine metabolism Folate biosynthesis Metabolic pathways Biosynthesis of cofactors		Post-translational modification: synthesis of GPI-anchored proteins

ALPG (alkaline phosphatase, germ cell)