Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23683
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase D3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKD3
Synonyms (NCBI Gene) Gene synonyms aliases
EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PKD3
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019291 hsa-miR-148b-3p Microarray 17612493
MIRT021381 hsa-miR-9-5p Microarray 17612493
MIRT024592 hsa-miR-215-5p Microarray 19074876
MIRT026308 hsa-miR-192-5p Microarray 19074876
MIRT050498 hsa-miR-20a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004697 Function Protein kinase C activity TAS 10231560
GO:0004698 Function Calcium-dependent protein kinase C activity IEA
GO:0005515 Function Protein binding IPI 17196367
GO:0005524 Function ATP binding IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607077 9408 ENSG00000115825
Protein
UniProt ID O94806
Protein name Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)
Protein function Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).
PDB 2D9Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 155 206 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 272 324 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00169 PH 417 532 PH domain Domain
PF00069 Pkinase 577 832 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV
SFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSEN
ILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVR
QGLKCEGCGLNYHKRCAFKIPNNCSG
VRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEES
HVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM
QCKDCKFNCHKRCASKVPRDCLGE
VTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDT
EEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKE
GWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQG
SNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALM
PVTPQASV
CTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGR
DVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDML
EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD
FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE
DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWL
QDYQTWLD
LREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
Sequence length 890
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Rap1 signaling pathway
Aldosterone synthesis and secretion
Chemical carcinogenesis - reactive oxygen species
  Sphingolipid de novo biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Unknown
Disease term Disease name Evidence References Source
Eosinophilia Eosinophilia GWAS
Schizophrenia Schizophrenia GWAS
Dementia Dementia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 27179279, 33878706
Alzheimer Disease Associate 34099642
Breast Neoplasms Associate 28656000, 34433666
Cholangiocarcinoma Associate 36231050
Death Associate 27179279
Leukemia Lymphocytic Chronic B Cell Associate 22675518
Neoplasm Metastasis Associate 33378018
Neoplasms Associate 22797919, 27179279, 28656000
Prostatic Neoplasms Associate 22797919, 36672148
Salivary Gland Neoplasms Associate 26426580, 31917707, 33878706