Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23659
Gene name Gene Name - the full gene name approved by the HGNC.
Phospholipase A2 group XV
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLA2G15
Synonyms (NCBI Gene) Gene synonyms aliases
ACS, GXVPLA2, LLPL, LPLA2, LYPLA3
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is presen
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1238535 hsa-let-7a CLIP-seq
MIRT1238536 hsa-let-7b CLIP-seq
MIRT1238537 hsa-let-7c CLIP-seq
MIRT1238538 hsa-let-7d CLIP-seq
MIRT1238539 hsa-let-7e CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Lysophospholipase activity IEA
GO:0004806 Function Triglyceride lipase activity IBA 21873635
GO:0005543 Function Phospholipid binding TAS 10092508
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609362 17163 ENSG00000103066
Protein
UniProt ID Q8NCC3
Protein name Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV
Protein function Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, P
PDB 4X90 , 4X91 , 4X92 , 4X93 , 4X94 , 4X95 , 4X97 , 6MTW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02450 LCAT 72 318 Lecithin:cholesterol acyltransferase Family
PF02450 LCAT 309 399 Lecithin:cholesterol acyltransferase Family
Tissue specificity TISSUE SPECIFICITY: Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary,
Sequence
MGLHLRPYRVGLLPDGLLFLLLLLMLLADPALPAGRHPPVVLVPGDLGNQLEAKLDKPTV
VHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGK
TFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREM
IEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVL
ASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQ
DIGFEDGW
LMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGD
GTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANA
TTLAYLKRVLLGP
Sequence length 412
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerophospholipid metabolism
Lysosome
Efferocytosis
  Hydrolysis of LPC
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
29483656
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27058892
alpha Thalassemia Associate 6725554
beta Thalassemia Associate 9057661
Colorectal Neoplasms Associate 29909608
Hypospadias Associate 31462596
Neoplasm Invasiveness Associate 29909608
Neoplasms Inhibit 27058892
Neoplasms Associate 29909608
Status Asthmaticus Associate 33626953