Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23635
Gene name Gene Name - the full gene name approved by the HGNC.
Single stranded DNA binding protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SSBP2
Synonyms (NCBI Gene) Gene synonyms aliases
HSPC116, SOSS-B2
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene ma
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT679312 hsa-miR-8062 HITS-CLIP 23824327
MIRT679311 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT679310 hsa-miR-4258 HITS-CLIP 23824327
MIRT679309 hsa-miR-7108-3p HITS-CLIP 23824327
MIRT679308 hsa-miR-4485-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003697 Function Single-stranded DNA binding NAS 12079286
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IDA
GO:0006355 Process Regulation of transcription, DNA-templated NAS 12079286
GO:0045944 Process Positive regulation of transcription by RNA polymerase II IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607389 15831 ENSG00000145687
Protein
UniProt ID P81877
Protein name Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)
PDB 6IWV , 6TYD , 8HIB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04503 SSDP 83 125 Family
PF04503 SSDP 124 338 Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12079286}.
Sequence
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGF
LHSWWCVFWDLYCAAPERRETCEHSSEAKAFHDYSAAAAPSPVLGNIPPGDGMPVGPVPP
GFF
QPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTP
PRGMVPLGPQNYGGAMRPPLNALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNY
VGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGM
ESHHMNGSLGSGDMDSISKNSPNNMSLSNQPGTPRDDG
EMGGNFLNPFQSESYSPSMTMS
V
Sequence length 361
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 22472174
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 18559593
Unknown
Disease term Disease name Evidence References Source
Anorexia Anorexia GWAS
Bipolar Disorder Bipolar Disorder GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 25824743
Cakut Associate 40774958
Carcinoma Hepatocellular Associate 30541499
Carcinoma Renal Cell Inhibit 31882468
Cholecystitis Associate 25066711
Esophageal Squamous Cell Carcinoma Inhibit 20658532, 30541499
Gallbladder Neoplasms Associate 25066711, 30541499
Glioblastoma Associate 22472174, 30541499
Hematologic Neoplasms Inhibit 30541499
Leukemia Myeloid Acute Associate 35412941