Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23594
Gene name	Origin recognition complex subunit 6
Gene symbol	ORC6
Synonyms (NCBI Gene)	ORC6L
Chromosome	16
Chromosome location	16q11.2
Summary	The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves

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SNP ID	Visualize variation	Clinical significance	Consequence
rs200089121	T>A,C	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs387906969	A>C	Pathogenic	Non coding transcript variant, coding sequence variant, genic downstream transcript variant, missense variant
rs572314014	G>A	Pathogenic	Intron variant
rs786205258	TT>-	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs879255692	AGAA>-	Pathogenic	Downstream transcript variant, genic downstream transcript variant, coding sequence variant, frameshift variant, non coding transcript variant

398

Show/Hide all (398)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016286	hsa-miR-193b-3p	Microarray	20304954
MIRT049645	hsa-miR-92a-3p	CLASH	23622248
MIRT041879	hsa-miR-484	CLASH	23622248
MIRT689529	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689528	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689527	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689526	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689525	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT689524	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT689523	hsa-miR-6134	HITS-CLIP	23313552
MIRT689522	hsa-miR-3926	HITS-CLIP	23313552
MIRT689521	hsa-miR-3672	HITS-CLIP	23313552
MIRT689520	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT689519	hsa-miR-548s	HITS-CLIP	23313552
MIRT642516	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642515	hsa-miR-662	HITS-CLIP	23824327
MIRT549668	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642514	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642513	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT549666	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642512	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642511	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT642510	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642509	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642508	hsa-miR-4284	HITS-CLIP	23824327
MIRT642507	hsa-miR-1297	HITS-CLIP	23824327
MIRT642506	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT642505	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT642504	hsa-miR-4465	HITS-CLIP	23824327
MIRT642503	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT642502	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	20371350
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	20371350
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570785	hsa-miR-3135b	PAR-CLIP	20371350
MIRT549664	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT549663	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT570784	hsa-miR-3652	PAR-CLIP	20371350
MIRT570783	hsa-miR-4430	PAR-CLIP	20371350
MIRT549668	hsa-miR-6741-3p	PAR-CLIP	21572407
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	21572407
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	21572407
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT549664	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549663	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT689529	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT689529	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689528	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689527	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689526	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689525	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT689524	hsa-miR-7854-3p	HITS-CLIP	23313552
MIRT689523	hsa-miR-6134	HITS-CLIP	23313552
MIRT689522	hsa-miR-3926	HITS-CLIP	23313552
MIRT689521	hsa-miR-3672	HITS-CLIP	23313552
MIRT689520	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT689519	hsa-miR-548s	HITS-CLIP	23313552
MIRT642516	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT642515	hsa-miR-662	HITS-CLIP	23824327
MIRT549668	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT642514	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT642513	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT549666	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT642512	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT642511	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT642510	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT642509	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT642508	hsa-miR-4284	HITS-CLIP	23824327
MIRT642507	hsa-miR-1297	HITS-CLIP	23824327
MIRT642506	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT642505	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT642504	hsa-miR-4465	HITS-CLIP	23824327
MIRT642503	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT642502	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	20371350
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	20371350
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	20371350
MIRT570785	hsa-miR-3135b	PAR-CLIP	20371350
MIRT549664	hsa-miR-504-3p	PAR-CLIP	20371350
MIRT549663	hsa-miR-122-5p	PAR-CLIP	20371350
MIRT570784	hsa-miR-3652	PAR-CLIP	20371350
MIRT570783	hsa-miR-4430	PAR-CLIP	20371350
MIRT549668	hsa-miR-6741-3p	PAR-CLIP	21572407
MIRT549667	hsa-miR-1307-3p	PAR-CLIP	21572407
MIRT549666	hsa-miR-4638-5p	PAR-CLIP	21572407
MIRT549665	hsa-miR-4746-3p	PAR-CLIP	21572407
MIRT549664	hsa-miR-504-3p	PAR-CLIP	21572407
MIRT549663	hsa-miR-122-5p	PAR-CLIP	21572407
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205655	hsa-miR-1264	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205658	hsa-miR-28-5p	CLIP-seq
MIRT1205659	hsa-miR-3139	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205661	hsa-miR-3150b-3p	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT1205670	hsa-miR-4487	CLIP-seq
MIRT1205671	hsa-miR-4689	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205673	hsa-miR-4712-3p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205678	hsa-miR-4784	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1205686	hsa-miR-708	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059249	hsa-miR-155	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT2059260	hsa-miR-4269	CLIP-seq
MIRT2059261	hsa-miR-4318	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT2059262	hsa-miR-4474-3p	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT2059263	hsa-miR-4484	CLIP-seq
MIRT2059264	hsa-miR-4505	CLIP-seq
MIRT2059265	hsa-miR-4514	CLIP-seq
MIRT2059266	hsa-miR-4692	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT2059268	hsa-miR-4742-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT2059280	hsa-miR-548an	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT2059281	hsa-miR-601	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq
MIRT2287346	hsa-miR-1	CLIP-seq
MIRT2287347	hsa-miR-1178	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205655	hsa-miR-1264	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059249	hsa-miR-155	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2287348	hsa-miR-206	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT2287349	hsa-miR-3194-5p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2287350	hsa-miR-3673	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT2059261	hsa-miR-4318	CLIP-seq
MIRT2287351	hsa-miR-4328	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT2059262	hsa-miR-4474-3p	CLIP-seq
MIRT2059264	hsa-miR-4505	CLIP-seq
MIRT2287352	hsa-miR-4690-3p	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT2059281	hsa-miR-601	CLIP-seq
MIRT2287353	hsa-miR-613	CLIP-seq
MIRT1205687	hsa-miR-720	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2585570	hsa-miR-132	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2585571	hsa-miR-212	CLIP-seq
MIRT2585572	hsa-miR-26a	CLIP-seq
MIRT2585573	hsa-miR-26b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT2287349	hsa-miR-3194-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1205664	hsa-miR-3929	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205666	hsa-miR-4419b	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205669	hsa-miR-4478	CLIP-seq
MIRT2059263	hsa-miR-4484	CLIP-seq
MIRT2585574	hsa-miR-4640-5p	CLIP-seq
MIRT2585575	hsa-miR-4661-3p	CLIP-seq
MIRT2287352	hsa-miR-4690-3p	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT2585576	hsa-miR-4709-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2585577	hsa-miR-4726-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT2585578	hsa-miR-4733-3p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT2059270	hsa-miR-499a-5p	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT2059280	hsa-miR-548an	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT2585579	hsa-miR-651	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq
MIRT2059245	hsa-miR-106a	CLIP-seq
MIRT2059246	hsa-miR-106b	CLIP-seq
MIRT1205653	hsa-miR-122	CLIP-seq
MIRT1922294	hsa-miR-1224-3p	CLIP-seq
MIRT1205654	hsa-miR-1228	CLIP-seq
MIRT1922295	hsa-miR-125a-3p	CLIP-seq
MIRT1205656	hsa-miR-1273f	CLIP-seq
MIRT2059247	hsa-miR-1307	CLIP-seq
MIRT2059248	hsa-miR-150	CLIP-seq
MIRT2059250	hsa-miR-17	CLIP-seq
MIRT1205657	hsa-miR-197	CLIP-seq
MIRT2059251	hsa-miR-20a	CLIP-seq
MIRT2059252	hsa-miR-20b	CLIP-seq
MIRT2059253	hsa-miR-302a	CLIP-seq
MIRT2059254	hsa-miR-302b	CLIP-seq
MIRT2059255	hsa-miR-302c	CLIP-seq
MIRT2059256	hsa-miR-302d	CLIP-seq
MIRT2059257	hsa-miR-302e	CLIP-seq
MIRT1205660	hsa-miR-3149	CLIP-seq
MIRT1205662	hsa-miR-3170	CLIP-seq
MIRT1205663	hsa-miR-3187-3p	CLIP-seq
MIRT1922296	hsa-miR-3663-5p	CLIP-seq
MIRT2059258	hsa-miR-372	CLIP-seq
MIRT2059259	hsa-miR-373	CLIP-seq
MIRT1922297	hsa-miR-3934	CLIP-seq
MIRT1205665	hsa-miR-411	CLIP-seq
MIRT1205667	hsa-miR-4435	CLIP-seq
MIRT1205668	hsa-miR-4438	CLIP-seq
MIRT1205672	hsa-miR-4701-5p	CLIP-seq
MIRT1205674	hsa-miR-4716-5p	CLIP-seq
MIRT2059267	hsa-miR-4731-5p	CLIP-seq
MIRT1205675	hsa-miR-4735-5p	CLIP-seq
MIRT1922298	hsa-miR-4755-3p	CLIP-seq
MIRT2059269	hsa-miR-4757-5p	CLIP-seq
MIRT1205676	hsa-miR-4775	CLIP-seq
MIRT1205677	hsa-miR-4781-3p	CLIP-seq
MIRT1205679	hsa-miR-4794	CLIP-seq
MIRT1205680	hsa-miR-501-3p	CLIP-seq
MIRT1205681	hsa-miR-502-3p	CLIP-seq
MIRT1205682	hsa-miR-5095	CLIP-seq
MIRT1205683	hsa-miR-5096	CLIP-seq
MIRT2059271	hsa-miR-512-3p	CLIP-seq
MIRT1922299	hsa-miR-516a-5p	CLIP-seq
MIRT2059272	hsa-miR-519d	CLIP-seq
MIRT2059273	hsa-miR-520a-3p	CLIP-seq
MIRT2059274	hsa-miR-520b	CLIP-seq
MIRT2059275	hsa-miR-520c-3p	CLIP-seq
MIRT2059276	hsa-miR-520d-3p	CLIP-seq
MIRT2059277	hsa-miR-520e	CLIP-seq
MIRT2059278	hsa-miR-520g	CLIP-seq
MIRT2059279	hsa-miR-520h	CLIP-seq
MIRT1205684	hsa-miR-588	CLIP-seq
MIRT1205685	hsa-miR-590-3p	CLIP-seq
MIRT1922300	hsa-miR-640	CLIP-seq
MIRT1922301	hsa-miR-764	CLIP-seq
MIRT1205688	hsa-miR-767-5p	CLIP-seq
MIRT2059282	hsa-miR-93	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000808	Component	Origin recognition complex	IDA	17716973
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15232106, 17716973, 18234858, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	32808929
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005664	Component	Nuclear origin of replication recognition complex	IBA
GO:0005664	Component	Nuclear origin of replication recognition complex	IEA
GO:0005664	Component	Nuclear origin of replication recognition complex	IPI	16549788
GO:0005829	Component	Cytosol	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006270	Process	DNA replication initiation	IBA
GO:0006270	Process	DNA replication initiation	IDA	16549788
GO:0016020	Component	Membrane	HDA	19946888

MIM	HGNC	e!Ensembl
607213	17151	ENSG00000091651

Q9Y5N6

Protein name

Origin recognition complex subunit 6

Protein function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-re

PDB

3M03 , 6KVG , 8S0B , 8S0D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05460	ORC6	6 → 96	Origin recognition complex subunit 6 (ORC6)	Family

Sequence

MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMK
CPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKS
YESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLE
KIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKIL
ENAASAQKATAE

Sequence length

252

Interactions

View interactions

	KEGG		Reactome
	Cell cycle		Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Meier-Gorlin syndrome 3	Pathogenic; Likely pathogenic	rs2143010039, rs1279789023, rs879255692, rs35441257, rs786205258, rs387906969, rs777153067, rs2548892306	RCV001527366 RCV001527365 RCV000239709 RCV005433474 RCV000023632 RCV000023633 RCV000499481 RCV001255839

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Conflicting classifications of pathogenicity	rs572314014	RCV005891090
Meier-Gorlin syndrome	Likely benign; Uncertain significance	rs568119196, rs60635029, rs753486103, rs779826723, rs756903337, rs771626686, rs886052017	RCV000289004 RCV000403174 RCV000297684 RCV000385060 RCV000324557 RCV000354843 RCV000328260 RCV000347439 RCV000312879 RCV000355991 RCV000267042
Melanoma	Uncertain significance	rs755961535	RCV005924342
ORC6-related disorder	Likely benign; Conflicting classifications of pathogenicity	rs1046633319, rs947702982, rs146795505, rs149896160	RCV003913635 RCV003926446 RCV004758677 RCV003940437
Papillary renal cell carcinoma type 1	Conflicting classifications of pathogenicity	rs572314014	RCV005891089
Sarcoma	Uncertain significance	rs369537126	RCV005922845
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs572314014	RCV005891091

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	36978046
Adenocarcinoma of Lung	Associate	36205357
Breast Neoplasms	Associate	35886011, 38104894
Carcinogenesis	Associate	36205357
Carcinoma Hepatocellular	Associate	37901236, 40255404
Colorectal Neoplasms	Stimulate	19112505, 37096556
DNA Virus Infections	Associate	37096556
Ear Diseases	Associate	23516378
Genetic Diseases Inborn	Associate	21358632
Glioma	Stimulate	37901236
Growth Disorders	Associate	21358632
Jeune syndrome	Associate	36012502
Meier Gorlin syndrome	Associate	21358632, 22333897, 23516378, 27374770, 29036220, 36012502
Musculoskeletal Abnormalities	Associate	23516378
Neoplasms	Associate	19112505, 36978046, 37901236
Prostatic Neoplasms	Associate	36978046
Sleep Initiation and Maintenance Disorders	Associate	32648482

ORC6 (origin recognition complex subunit 6)