Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2359
Gene name Gene Name - the full gene name approved by the HGNC.	Formyl peptide receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FPR3
Synonyms (NCBI Gene) Gene synonyms aliases	FML2_HUMAN, FMLP-R-II, FMLPY, FPRH1, FPRH2, FPRL2, RMLP-R-I
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.41

Show/Hide all(63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT614160	hsa-miR-3912-3p	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT611085	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT611084	hsa-miR-572	HITS-CLIP	23824327
MIRT611083	hsa-miR-718	HITS-CLIP	23824327
MIRT1003965	hsa-miR-1	CLIP-seq
MIRT1003966	hsa-miR-141	CLIP-seq
MIRT1003967	hsa-miR-200a	CLIP-seq
MIRT1003968	hsa-miR-206	CLIP-seq
MIRT1003969	hsa-miR-3673	CLIP-seq
MIRT1003970	hsa-miR-3690	CLIP-seq
MIRT1003971	hsa-miR-4254	CLIP-seq
MIRT1003972	hsa-miR-4501	CLIP-seq
MIRT1003973	hsa-miR-4793-5p	CLIP-seq
MIRT1003974	hsa-miR-613	CLIP-seq
MIRT1997577	hsa-miR-3682-5p	CLIP-seq
MIRT1997578	hsa-miR-4528	CLIP-seq
MIRT2388174	hsa-miR-217	CLIP-seq
MIRT2388175	hsa-miR-219-5p	CLIP-seq
MIRT2388176	hsa-miR-3126-3p	CLIP-seq
MIRT2388177	hsa-miR-323-5p	CLIP-seq
MIRT2388178	hsa-miR-3682-3p	CLIP-seq
MIRT2388179	hsa-miR-4445	CLIP-seq
MIRT2388180	hsa-miR-4477a	CLIP-seq
MIRT2388181	hsa-miR-4490	CLIP-seq
MIRT2388182	hsa-miR-4699-3p	CLIP-seq
MIRT2388183	hsa-miR-4738-3p	CLIP-seq
MIRT2388184	hsa-miR-4774-5p	CLIP-seq
MIRT2388185	hsa-miR-4781-3p	CLIP-seq
MIRT2388186	hsa-miR-4782-3p	CLIP-seq
MIRT2388187	hsa-miR-508-3p	CLIP-seq
MIRT2388188	hsa-miR-876-3p	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002430	Process	Complement receptor mediated signaling pathway	IBA
GO:0004875	Function	Complement receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004982	Function	N-formyl peptide receptor activity	IBA
GO:0004982	Function	N-formyl peptide receptor activity	TAS	8198572
GO:0005515	Function	Protein binding	IPI	15465011
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8198572
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	8198572
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8198572
GO:0023052	Process	Signaling	IEA

MIM	HGNC	e!Ensembl
136539	3828	ENSG00000187474

Protein

UniProt ID

P25089

Protein name

N-formyl peptide receptor 3 (FMLP-related receptor II) (FMLP-R-II) (Formyl peptide receptor-like 2)

Protein function

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidyli

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	43 → 302	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in various tissues with highest expression in lung. {ECO:0000269|PubMed:15465011}.

Sequence

METNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVN
TICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIA
LDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNF
AFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPL
RVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPI
LYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM

Sequence length

353

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Neutrophil extracellular trap formation Staphylococcus aureus infection		G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma	N/A	N/A	GWAS
Tourette Syndrome	Tourette syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	28351365
Colorectal Neoplasms	Stimulate	29364475
Diabetic Nephropathies	Associate	34735495
Drug Hypersensitivity	Associate	31330220
Fetal Growth Retardation	Associate	33256815
Glioma	Associate	33408717
Hypertension	Associate	31116781
Latent Infection	Associate	32971238
Placental Insufficiency	Associate	33256815
Pulmonary Disease Chronic Obstructive	Associate	29544524
Sleep Apnea Obstructive	Associate	31116781
Smoke Inhalation Injury	Stimulate	33078507
Tuberculosis Meningeal	Inhibit	32971238

FPR3 (formyl peptide receptor 3)