Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23586
Gene name	RNA sensor RIG-I
Gene symbol	RIGI
Synonyms (NCBI Gene)	DDX58RIG-IRIG1RLR-1SGMRT2
Chromosome	9
Chromosome location	9p21.1

Show/Hide all (5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs786204847	T>G	Pathogenic	Coding sequence variant, missense variant
rs786204848	C>A	Pathogenic	Coding sequence variant, missense variant
rs1064795754	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1131691305	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1587586052	T>A	Likely-pathogenic	Missense variant, coding sequence variant

403

Show/Hide all (403)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437784	hsa-miR-10b-5p	Luciferase reporter assay	25312779
MIRT440833	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440833	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT734373	hsa-miR-579-3p	ELISALuciferase reporter assayRNA-seqWestern blotting	32209695
MIRT734374	hsa-miR-221-3p	ELISALuciferase reporter assayRNA-seqWestern blotting	32209695
MIRT735668	hsa-miR-149-5p	Luciferase reporter assayWestern blottingqRT-PCR	32232013
MIRT931301	hsa-miR-101	CLIP-seq
MIRT931302	hsa-miR-1262	CLIP-seq
MIRT931303	hsa-miR-127-5p	CLIP-seq
MIRT931304	hsa-miR-1293	CLIP-seq
MIRT931305	hsa-miR-142-5p	CLIP-seq
MIRT931306	hsa-miR-144	CLIP-seq
MIRT931307	hsa-miR-146a	CLIP-seq
MIRT931308	hsa-miR-146b-5p	CLIP-seq
MIRT931309	hsa-miR-186	CLIP-seq
MIRT931310	hsa-miR-2681	CLIP-seq
MIRT931311	hsa-miR-298	CLIP-seq
MIRT931312	hsa-miR-3133	CLIP-seq
MIRT931313	hsa-miR-3144-5p	CLIP-seq
MIRT931314	hsa-miR-3150b-3p	CLIP-seq
MIRT931315	hsa-miR-3154	CLIP-seq
MIRT931316	hsa-miR-3163	CLIP-seq
MIRT931317	hsa-miR-3179	CLIP-seq
MIRT931318	hsa-miR-3188	CLIP-seq
MIRT931319	hsa-miR-3191	CLIP-seq
MIRT931320	hsa-miR-3200-3p	CLIP-seq
MIRT931321	hsa-miR-340	CLIP-seq
MIRT931322	hsa-miR-3651	CLIP-seq
MIRT931323	hsa-miR-3664-3p	CLIP-seq
MIRT931324	hsa-miR-4271	CLIP-seq
MIRT931325	hsa-miR-4483	CLIP-seq
MIRT931326	hsa-miR-4496	CLIP-seq
MIRT931327	hsa-miR-4652-5p	CLIP-seq
MIRT931328	hsa-miR-4666-5p	CLIP-seq
MIRT931329	hsa-miR-4689	CLIP-seq
MIRT931330	hsa-miR-4695-3p	CLIP-seq
MIRT931331	hsa-miR-4695-5p	CLIP-seq
MIRT931332	hsa-miR-4701-3p	CLIP-seq
MIRT931333	hsa-miR-4711-5p	CLIP-seq
MIRT931334	hsa-miR-4725-3p	CLIP-seq
MIRT931335	hsa-miR-4729	CLIP-seq
MIRT931336	hsa-miR-4784	CLIP-seq
MIRT931337	hsa-miR-491-5p	CLIP-seq
MIRT931338	hsa-miR-545	CLIP-seq
MIRT931339	hsa-miR-548aa	CLIP-seq
MIRT931340	hsa-miR-548c-3p	CLIP-seq
MIRT931341	hsa-miR-583	CLIP-seq
MIRT931342	hsa-miR-589	CLIP-seq
MIRT931343	hsa-miR-873	CLIP-seq
MIRT1975611	hsa-miR-374a	CLIP-seq
MIRT1975612	hsa-miR-374b	CLIP-seq
MIRT1975613	hsa-miR-4450	CLIP-seq
MIRT1975614	hsa-miR-4643	CLIP-seq
MIRT1975615	hsa-miR-4684-5p	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT1975617	hsa-miR-4733-5p	CLIP-seq
MIRT1975618	hsa-miR-4760-3p	CLIP-seq
MIRT1975619	hsa-miR-498	CLIP-seq
MIRT1975620	hsa-miR-642b	CLIP-seq
MIRT1975621	hsa-miR-656	CLIP-seq
MIRT931301	hsa-miR-101	CLIP-seq
MIRT2211110	hsa-miR-1245b-3p	CLIP-seq
MIRT931302	hsa-miR-1262	CLIP-seq
MIRT2211111	hsa-miR-1271	CLIP-seq
MIRT2211112	hsa-miR-1290	CLIP-seq
MIRT931304	hsa-miR-1293	CLIP-seq
MIRT931306	hsa-miR-144	CLIP-seq
MIRT931307	hsa-miR-146a	CLIP-seq
MIRT931308	hsa-miR-146b-5p	CLIP-seq
MIRT2211113	hsa-miR-1470	CLIP-seq
MIRT2211114	hsa-miR-182	CLIP-seq
MIRT2211115	hsa-miR-1915	CLIP-seq
MIRT931313	hsa-miR-3144-5p	CLIP-seq
MIRT931316	hsa-miR-3163	CLIP-seq
MIRT2211116	hsa-miR-3167	CLIP-seq
MIRT931319	hsa-miR-3191	CLIP-seq
MIRT931321	hsa-miR-340	CLIP-seq
MIRT2211117	hsa-miR-3680	CLIP-seq
MIRT2211118	hsa-miR-3681	CLIP-seq
MIRT2211119	hsa-miR-3692	CLIP-seq
MIRT1975611	hsa-miR-374a	CLIP-seq
MIRT1975612	hsa-miR-374b	CLIP-seq
MIRT2211120	hsa-miR-3925-5p	CLIP-seq
MIRT2211121	hsa-miR-4270	CLIP-seq
MIRT2211122	hsa-miR-4287	CLIP-seq
MIRT2211123	hsa-miR-4311	CLIP-seq
MIRT2211124	hsa-miR-4441	CLIP-seq
MIRT1975613	hsa-miR-4450	CLIP-seq
MIRT931325	hsa-miR-4483	CLIP-seq
MIRT2211125	hsa-miR-4637	CLIP-seq
MIRT1975614	hsa-miR-4643	CLIP-seq
MIRT931327	hsa-miR-4652-5p	CLIP-seq
MIRT931328	hsa-miR-4666-5p	CLIP-seq
MIRT2211126	hsa-miR-4667-3p	CLIP-seq
MIRT2211127	hsa-miR-4685-3p	CLIP-seq
MIRT931330	hsa-miR-4695-3p	CLIP-seq
MIRT931332	hsa-miR-4701-3p	CLIP-seq
MIRT2211128	hsa-miR-4705	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT1975617	hsa-miR-4733-5p	CLIP-seq
MIRT1975618	hsa-miR-4760-3p	CLIP-seq
MIRT2211129	hsa-miR-4773	CLIP-seq
MIRT2211130	hsa-miR-4780	CLIP-seq
MIRT2211131	hsa-miR-4802-3p	CLIP-seq
MIRT931337	hsa-miR-491-5p	CLIP-seq
MIRT2211132	hsa-miR-514	CLIP-seq
MIRT2211133	hsa-miR-514b-3p	CLIP-seq
MIRT931339	hsa-miR-548aa	CLIP-seq
MIRT2211134	hsa-miR-549	CLIP-seq
MIRT931342	hsa-miR-589	CLIP-seq
MIRT2211135	hsa-miR-623	CLIP-seq
MIRT1975620	hsa-miR-642b	CLIP-seq
MIRT2211136	hsa-miR-876-5p	CLIP-seq
MIRT2211137	hsa-miR-885-3p	CLIP-seq
MIRT2211138	hsa-miR-922	CLIP-seq
MIRT2211139	hsa-miR-96	CLIP-seq
MIRT2386823	hsa-miR-1244	CLIP-seq
MIRT2386824	hsa-miR-128	CLIP-seq
MIRT2386825	hsa-miR-139-5p	CLIP-seq
MIRT2386826	hsa-miR-27a	CLIP-seq
MIRT2386827	hsa-miR-27b	CLIP-seq
MIRT2386828	hsa-miR-31	CLIP-seq
MIRT2386829	hsa-miR-3120-3p	CLIP-seq
MIRT2386830	hsa-miR-3138	CLIP-seq
MIRT2211119	hsa-miR-3692	CLIP-seq
MIRT2211120	hsa-miR-3925-5p	CLIP-seq
MIRT2386831	hsa-miR-4436b-3p	CLIP-seq
MIRT2386832	hsa-miR-4520a-3p	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT2386833	hsa-miR-4761-3p	CLIP-seq
MIRT2386834	hsa-miR-618	CLIP-seq
MIRT2386835	hsa-miR-633	CLIP-seq
MIRT2211110	hsa-miR-1245b-3p	CLIP-seq
MIRT2386824	hsa-miR-128	CLIP-seq
MIRT2386826	hsa-miR-27a	CLIP-seq
MIRT2386827	hsa-miR-27b	CLIP-seq
MIRT931314	hsa-miR-3150b-3p	CLIP-seq
MIRT2448135	hsa-miR-362-5p	CLIP-seq
MIRT2211119	hsa-miR-3692	CLIP-seq
MIRT931329	hsa-miR-4689	CLIP-seq
MIRT931331	hsa-miR-4695-5p	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT931336	hsa-miR-4784	CLIP-seq
MIRT2448136	hsa-miR-500b	CLIP-seq
MIRT2448137	hsa-miR-501-5p	CLIP-seq
MIRT2514942	hsa-miR-1178	CLIP-seq
MIRT2514943	hsa-miR-1226	CLIP-seq
MIRT2211110	hsa-miR-1245b-3p	CLIP-seq
MIRT2514944	hsa-miR-1257	CLIP-seq
MIRT2514945	hsa-miR-1261	CLIP-seq
MIRT931302	hsa-miR-1262	CLIP-seq
MIRT2514946	hsa-miR-1264	CLIP-seq
MIRT2514947	hsa-miR-1267	CLIP-seq
MIRT2514948	hsa-miR-1283	CLIP-seq
MIRT931304	hsa-miR-1293	CLIP-seq
MIRT2514949	hsa-miR-1297	CLIP-seq
MIRT2514950	hsa-miR-1321	CLIP-seq
MIRT931307	hsa-miR-146a	CLIP-seq
MIRT931308	hsa-miR-146b-5p	CLIP-seq
MIRT2514951	hsa-miR-148a	CLIP-seq
MIRT2514952	hsa-miR-148b	CLIP-seq
MIRT2514953	hsa-miR-149	CLIP-seq
MIRT2514954	hsa-miR-152	CLIP-seq
MIRT2514955	hsa-miR-181a	CLIP-seq
MIRT2514956	hsa-miR-181b	CLIP-seq
MIRT2514957	hsa-miR-181c	CLIP-seq
MIRT2514958	hsa-miR-181d	CLIP-seq
MIRT2514959	hsa-miR-1827	CLIP-seq
MIRT2514960	hsa-miR-183	CLIP-seq
MIRT2514961	hsa-miR-1910	CLIP-seq
MIRT2514962	hsa-miR-194	CLIP-seq
MIRT2514963	hsa-miR-219-2-3p	CLIP-seq
MIRT2514964	hsa-miR-2467-5p	CLIP-seq
MIRT931310	hsa-miR-2681	CLIP-seq
MIRT2514965	hsa-miR-26a	CLIP-seq
MIRT2514966	hsa-miR-26b	CLIP-seq
MIRT931311	hsa-miR-298	CLIP-seq
MIRT2514967	hsa-miR-3064-5p	CLIP-seq
MIRT2386828	hsa-miR-31	CLIP-seq
MIRT2514968	hsa-miR-3119	CLIP-seq
MIRT2514969	hsa-miR-3121-3p	CLIP-seq
MIRT2514970	hsa-miR-3130-3p	CLIP-seq
MIRT931313	hsa-miR-3144-5p	CLIP-seq
MIRT931315	hsa-miR-3154	CLIP-seq
MIRT931316	hsa-miR-3163	CLIP-seq
MIRT2514971	hsa-miR-3171	CLIP-seq
MIRT2514972	hsa-miR-3173-3p	CLIP-seq
MIRT931317	hsa-miR-3179	CLIP-seq
MIRT931318	hsa-miR-3188	CLIP-seq
MIRT931319	hsa-miR-3191	CLIP-seq
MIRT2514973	hsa-miR-3200-5p	CLIP-seq
MIRT2514974	hsa-miR-326	CLIP-seq
MIRT2514975	hsa-miR-330-5p	CLIP-seq
MIRT2514976	hsa-miR-3607-3p	CLIP-seq
MIRT2514977	hsa-miR-3612	CLIP-seq
MIRT2448135	hsa-miR-362-5p	CLIP-seq
MIRT2514978	hsa-miR-3646	CLIP-seq
MIRT931322	hsa-miR-3651	CLIP-seq
MIRT2514979	hsa-miR-3662	CLIP-seq
MIRT2514980	hsa-miR-3670	CLIP-seq
MIRT2514981	hsa-miR-3671	CLIP-seq
MIRT2514982	hsa-miR-3686	CLIP-seq
MIRT1975611	hsa-miR-374a	CLIP-seq
MIRT1975612	hsa-miR-374b	CLIP-seq
MIRT2514983	hsa-miR-3908	CLIP-seq
MIRT2211120	hsa-miR-3925-5p	CLIP-seq
MIRT2514984	hsa-miR-3934	CLIP-seq
MIRT2514985	hsa-miR-3942-5p	CLIP-seq
MIRT2514986	hsa-miR-3975	CLIP-seq
MIRT2514987	hsa-miR-4251	CLIP-seq
MIRT2514988	hsa-miR-4262	CLIP-seq
MIRT931324	hsa-miR-4271	CLIP-seq
MIRT2211123	hsa-miR-4311	CLIP-seq
MIRT2514989	hsa-miR-4329	CLIP-seq
MIRT2514990	hsa-miR-4419a	CLIP-seq
MIRT2386831	hsa-miR-4436b-3p	CLIP-seq
MIRT2514991	hsa-miR-4446-5p	CLIP-seq
MIRT1975613	hsa-miR-4450	CLIP-seq
MIRT2514992	hsa-miR-4462	CLIP-seq
MIRT2514993	hsa-miR-4465	CLIP-seq
MIRT931325	hsa-miR-4483	CLIP-seq
MIRT2514994	hsa-miR-4494	CLIP-seq
MIRT931326	hsa-miR-4496	CLIP-seq
MIRT2514995	hsa-miR-4510	CLIP-seq
MIRT2514996	hsa-miR-4522	CLIP-seq
MIRT2514997	hsa-miR-4528	CLIP-seq
MIRT2514998	hsa-miR-455-3p	CLIP-seq
MIRT1975614	hsa-miR-4643	CLIP-seq
MIRT931327	hsa-miR-4652-5p	CLIP-seq
MIRT2514999	hsa-miR-4662a-5p	CLIP-seq
MIRT931328	hsa-miR-4666-5p	CLIP-seq
MIRT2515000	hsa-miR-4690-5p	CLIP-seq
MIRT2515001	hsa-miR-4693-3p	CLIP-seq
MIRT931330	hsa-miR-4695-3p	CLIP-seq
MIRT931332	hsa-miR-4701-3p	CLIP-seq
MIRT2515002	hsa-miR-4703-5p	CLIP-seq
MIRT2515003	hsa-miR-4709-3p	CLIP-seq
MIRT2515004	hsa-miR-4712-3p	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT931334	hsa-miR-4725-3p	CLIP-seq
MIRT2515005	hsa-miR-4733-3p	CLIP-seq
MIRT2515006	hsa-miR-4739	CLIP-seq
MIRT2515007	hsa-miR-4742-5p	CLIP-seq
MIRT2515008	hsa-miR-4756-5p	CLIP-seq
MIRT1975618	hsa-miR-4760-3p	CLIP-seq
MIRT2386833	hsa-miR-4761-3p	CLIP-seq
MIRT2515009	hsa-miR-4766-3p	CLIP-seq
MIRT2515010	hsa-miR-4768-5p	CLIP-seq
MIRT2211129	hsa-miR-4773	CLIP-seq
MIRT2515011	hsa-miR-4775	CLIP-seq
MIRT2515012	hsa-miR-4794	CLIP-seq
MIRT2211131	hsa-miR-4802-3p	CLIP-seq
MIRT2515013	hsa-miR-485-5p	CLIP-seq
MIRT931337	hsa-miR-491-5p	CLIP-seq
MIRT1975619	hsa-miR-498	CLIP-seq
MIRT2515014	hsa-miR-499a-5p	CLIP-seq
MIRT2448136	hsa-miR-500b	CLIP-seq
MIRT2448137	hsa-miR-501-5p	CLIP-seq
MIRT2515015	hsa-miR-510	CLIP-seq
MIRT2515016	hsa-miR-512-3p	CLIP-seq
MIRT2515017	hsa-miR-512-5p	CLIP-seq
MIRT2515018	hsa-miR-522	CLIP-seq
MIRT931339	hsa-miR-548aa	CLIP-seq
MIRT2515019	hsa-miR-548ac	CLIP-seq
MIRT931340	hsa-miR-548c-3p	CLIP-seq
MIRT2515020	hsa-miR-548d-3p	CLIP-seq
MIRT2515021	hsa-miR-548z	CLIP-seq
MIRT2515022	hsa-miR-556-5p	CLIP-seq
MIRT2515023	hsa-miR-574-5p	CLIP-seq
MIRT2515024	hsa-miR-576-5p	CLIP-seq
MIRT931342	hsa-miR-589	CLIP-seq
MIRT2515025	hsa-miR-590-3p	CLIP-seq
MIRT2515026	hsa-miR-600	CLIP-seq
MIRT2386835	hsa-miR-633	CLIP-seq
MIRT1975620	hsa-miR-642b	CLIP-seq
MIRT2515027	hsa-miR-650	CLIP-seq
MIRT2515028	hsa-miR-653	CLIP-seq
MIRT2515029	hsa-miR-767-3p	CLIP-seq
MIRT2515030	hsa-miR-767-5p	CLIP-seq
MIRT2211137	hsa-miR-885-3p	CLIP-seq
MIRT2211138	hsa-miR-922	CLIP-seq
MIRT2514942	hsa-miR-1178	CLIP-seq
MIRT2514943	hsa-miR-1226	CLIP-seq
MIRT2211110	hsa-miR-1245b-3p	CLIP-seq
MIRT2514944	hsa-miR-1257	CLIP-seq
MIRT2514945	hsa-miR-1261	CLIP-seq
MIRT931302	hsa-miR-1262	CLIP-seq
MIRT2514946	hsa-miR-1264	CLIP-seq
MIRT2514947	hsa-miR-1267	CLIP-seq
MIRT2514948	hsa-miR-1283	CLIP-seq
MIRT931304	hsa-miR-1293	CLIP-seq
MIRT2514949	hsa-miR-1297	CLIP-seq
MIRT2514950	hsa-miR-1321	CLIP-seq
MIRT931307	hsa-miR-146a	CLIP-seq
MIRT931308	hsa-miR-146b-5p	CLIP-seq
MIRT2514953	hsa-miR-149	CLIP-seq
MIRT2514955	hsa-miR-181a	CLIP-seq
MIRT2514956	hsa-miR-181b	CLIP-seq
MIRT2514957	hsa-miR-181c	CLIP-seq
MIRT2514958	hsa-miR-181d	CLIP-seq
MIRT2514959	hsa-miR-1827	CLIP-seq
MIRT2514960	hsa-miR-183	CLIP-seq
MIRT2514961	hsa-miR-1910	CLIP-seq
MIRT2514962	hsa-miR-194	CLIP-seq
MIRT2514963	hsa-miR-219-2-3p	CLIP-seq
MIRT2514964	hsa-miR-2467-5p	CLIP-seq
MIRT931310	hsa-miR-2681	CLIP-seq
MIRT2514965	hsa-miR-26a	CLIP-seq
MIRT2514966	hsa-miR-26b	CLIP-seq
MIRT931311	hsa-miR-298	CLIP-seq
MIRT2514967	hsa-miR-3064-5p	CLIP-seq
MIRT2386828	hsa-miR-31	CLIP-seq
MIRT2514968	hsa-miR-3119	CLIP-seq
MIRT2514969	hsa-miR-3121-3p	CLIP-seq
MIRT2514970	hsa-miR-3130-3p	CLIP-seq
MIRT931313	hsa-miR-3144-5p	CLIP-seq
MIRT931315	hsa-miR-3154	CLIP-seq
MIRT931316	hsa-miR-3163	CLIP-seq
MIRT2514971	hsa-miR-3171	CLIP-seq
MIRT2514972	hsa-miR-3173-3p	CLIP-seq
MIRT931317	hsa-miR-3179	CLIP-seq
MIRT931318	hsa-miR-3188	CLIP-seq
MIRT931319	hsa-miR-3191	CLIP-seq
MIRT2514973	hsa-miR-3200-5p	CLIP-seq
MIRT2514974	hsa-miR-326	CLIP-seq
MIRT2514975	hsa-miR-330-5p	CLIP-seq
MIRT2514976	hsa-miR-3607-3p	CLIP-seq
MIRT2514977	hsa-miR-3612	CLIP-seq
MIRT931322	hsa-miR-3651	CLIP-seq
MIRT2514980	hsa-miR-3670	CLIP-seq
MIRT2514981	hsa-miR-3671	CLIP-seq
MIRT2514982	hsa-miR-3686	CLIP-seq
MIRT1975611	hsa-miR-374a	CLIP-seq
MIRT1975612	hsa-miR-374b	CLIP-seq
MIRT2514983	hsa-miR-3908	CLIP-seq
MIRT2211120	hsa-miR-3925-5p	CLIP-seq
MIRT2514984	hsa-miR-3934	CLIP-seq
MIRT2514985	hsa-miR-3942-5p	CLIP-seq
MIRT2514986	hsa-miR-3975	CLIP-seq
MIRT2514987	hsa-miR-4251	CLIP-seq
MIRT2514988	hsa-miR-4262	CLIP-seq
MIRT931324	hsa-miR-4271	CLIP-seq
MIRT2211123	hsa-miR-4311	CLIP-seq
MIRT2514989	hsa-miR-4329	CLIP-seq
MIRT2514990	hsa-miR-4419a	CLIP-seq
MIRT2386831	hsa-miR-4436b-3p	CLIP-seq
MIRT2514991	hsa-miR-4446-5p	CLIP-seq
MIRT1975613	hsa-miR-4450	CLIP-seq
MIRT2514992	hsa-miR-4462	CLIP-seq
MIRT2514993	hsa-miR-4465	CLIP-seq
MIRT931325	hsa-miR-4483	CLIP-seq
MIRT2514994	hsa-miR-4494	CLIP-seq
MIRT931326	hsa-miR-4496	CLIP-seq
MIRT2514995	hsa-miR-4510	CLIP-seq
MIRT2514996	hsa-miR-4522	CLIP-seq
MIRT2514997	hsa-miR-4528	CLIP-seq
MIRT2514998	hsa-miR-455-3p	CLIP-seq
MIRT1975614	hsa-miR-4643	CLIP-seq
MIRT931327	hsa-miR-4652-5p	CLIP-seq
MIRT2514999	hsa-miR-4662a-5p	CLIP-seq
MIRT931328	hsa-miR-4666-5p	CLIP-seq
MIRT2515000	hsa-miR-4690-5p	CLIP-seq
MIRT2515001	hsa-miR-4693-3p	CLIP-seq
MIRT931332	hsa-miR-4701-3p	CLIP-seq
MIRT2515002	hsa-miR-4703-5p	CLIP-seq
MIRT2515003	hsa-miR-4709-3p	CLIP-seq
MIRT2515004	hsa-miR-4712-3p	CLIP-seq
MIRT1975616	hsa-miR-4717-3p	CLIP-seq
MIRT931334	hsa-miR-4725-3p	CLIP-seq
MIRT2515005	hsa-miR-4733-3p	CLIP-seq
MIRT2515006	hsa-miR-4739	CLIP-seq
MIRT2515007	hsa-miR-4742-5p	CLIP-seq
MIRT2515008	hsa-miR-4756-5p	CLIP-seq
MIRT1975618	hsa-miR-4760-3p	CLIP-seq
MIRT2386833	hsa-miR-4761-3p	CLIP-seq
MIRT2515009	hsa-miR-4766-3p	CLIP-seq
MIRT2515010	hsa-miR-4768-5p	CLIP-seq
MIRT2211129	hsa-miR-4773	CLIP-seq
MIRT2515011	hsa-miR-4775	CLIP-seq
MIRT2515012	hsa-miR-4794	CLIP-seq
MIRT2211131	hsa-miR-4802-3p	CLIP-seq
MIRT2515013	hsa-miR-485-5p	CLIP-seq
MIRT931337	hsa-miR-491-5p	CLIP-seq
MIRT1975619	hsa-miR-498	CLIP-seq
MIRT2515014	hsa-miR-499a-5p	CLIP-seq
MIRT2515015	hsa-miR-510	CLIP-seq
MIRT2515017	hsa-miR-512-5p	CLIP-seq
MIRT2515018	hsa-miR-522	CLIP-seq
MIRT931340	hsa-miR-548c-3p	CLIP-seq
MIRT2515022	hsa-miR-556-5p	CLIP-seq
MIRT2515023	hsa-miR-574-5p	CLIP-seq
MIRT2515024	hsa-miR-576-5p	CLIP-seq
MIRT931342	hsa-miR-589	CLIP-seq
MIRT2515025	hsa-miR-590-3p	CLIP-seq
MIRT2515026	hsa-miR-600	CLIP-seq
MIRT2386835	hsa-miR-633	CLIP-seq
MIRT1975620	hsa-miR-642b	CLIP-seq
MIRT2515027	hsa-miR-650	CLIP-seq
MIRT2515028	hsa-miR-653	CLIP-seq
MIRT2515029	hsa-miR-767-3p	CLIP-seq
MIRT2515030	hsa-miR-767-5p	CLIP-seq
MIRT2211137	hsa-miR-885-3p	CLIP-seq
MIRT2211138	hsa-miR-922	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
IRF1	Activation	22391244
TRIM25	Unknown	21292167

Show/Hide all (86)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002230	Process	Positive regulation of defense response to virus by host	IMP	19609254
GO:0002376	Process	Immune system process	IEA
GO:0002684	Process	Positive regulation of immune system process	IEA
GO:0002735	Process	Positive regulation of myeloid dendritic cell cytokine production	IEA
GO:0002735	Process	Positive regulation of myeloid dendritic cell cytokine production	ISS
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IBA
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IDA	16125763, 17392790, 29441066
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	IDA	19576794
GO:0002753	Process	Cytoplasmic pattern recognition receptor signaling pathway	TAS	21616437
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003724	Function	RNA helicase activity	IMP	19211564
GO:0003725	Function	Double-stranded RNA binding	IBA
GO:0003725	Function	Double-stranded RNA binding	IDA	19576794
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IMP	19211564
GO:0003725	Function	Double-stranded RNA binding	TAS	17079289
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IMP	19211564
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	16127453, 16177806, 16281057, 16585524, 17079289, 17190814, 17460044, 17709747, 18200010, 18636086, 18724357, 18818105, 19017631, 19164550, 19193793, 19380580, 19419966, 20007272, 20080758, 20127681, 20434986, 20818395, 21102435, 21233210, 21791617, 21813773, 21844353, 21903422, 221
GO:0005524	Function	ATP binding	IEA
GO:0005525	Function	GTP binding	IMP	21233210
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15208624, 27807226
GO:0005737	Component	Cytoplasm	IDA	21102435
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005923	Component	Bicellular tight junction	IDA	19122199
GO:0005923	Component	Bicellular tight junction	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	18243112
GO:0009299	Process	MRNA transcription	IDA	9891032
GO:0009597	Process	Detection of virus	IDA	17079289
GO:0009615	Process	Response to virus	IEA
GO:0009615	Process	Response to virus	TAS	21616437
GO:0010467	Process	Gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	24409285
GO:0015629	Component	Actin cytoskeleton	IDA	19122199
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IMP	19211564
GO:0030334	Process	Regulation of cell migration	IDA	19122199
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	23950712, 26471729, 31006531
GO:0032587	Component	Ruffle membrane	IDA	19122199
GO:0032587	Component	Ruffle membrane	IEA
GO:0032725	Process	Positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	24409285
GO:0032727	Process	Positive regulation of interferon-alpha production	IDA	19576794
GO:0032727	Process	Positive regulation of interferon-alpha production	IMP	19609254, 21957149
GO:0032728	Process	Positive regulation of interferon-beta production	IDA	17079289
GO:0032728	Process	Positive regulation of interferon-beta production	IEA
GO:0032728	Process	Positive regulation of interferon-beta production	IMP	19609254, 19631370, 21957149
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	24409285
GO:0032755	Process	Positive regulation of interleukin-6 production	IMP	21957149
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	24409285
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IMP	21957149
GO:0034344	Process	Regulation of type III interferon production	TAS	21616437
GO:0038187	Function	Pattern recognition receptor activity	IDA	19576794, 25119032, 28469175, 35263596
GO:0039529	Process	RIG-I signaling pathway	IDA	28469175
GO:0039529	Process	RIG-I signaling pathway	IMP	19211564
GO:0042802	Function	Identical protein binding	IPI	17190814, 20581823, 21102435, 24590070, 34544279
GO:0042995	Component	Cell projection	IEA
GO:0043330	Process	Response to exogenous dsRNA	IEA
GO:0043330	Process	Response to exogenous dsRNA	IEA
GO:0043330	Process	Response to exogenous dsRNA	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	19609254, 19631370
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17079289
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	IEA
GO:0060760	Process	Positive regulation of response to cytokine stimulus	IMP	21957149
GO:0070161	Component	Anchoring junction	IEA
GO:0071360	Process	Cellular response to exogenous dsRNA	IMP	21957149
GO:0140374	Process	Antiviral innate immune response	IBA
GO:0140374	Process	Antiviral innate immune response	IDA	9891032, 14703513, 17392790, 18984593, 27992402
GO:0140374	Process	Antiviral innate immune response	IDA	28469175
GO:1990904	Component	Ribonucleoprotein complex	IDA	31006531

MIM	HGNC	e!Ensembl
609631	19102	ENSG00000107201

O95786

Protein name

Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I prot

Protein function

Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, Pu

PDB

2LWD , 2LWE , 2QFB , 2QFD , 2RMJ , 2YKG , 3LRN , 3LRR , 3NCU , 3OG8 , 3ZD6 , 3ZD7 , 4AY2 , 4BPB , 4NQK , 4ON9 , 4P4H , 5E3H , 5F98 , 5F9F , 5F9H , 6GPG , 6KYV , 7BAH , 7BAI , 7JL1 , 7JL3 , 7MK1 , 7TNX , 7TNY , 7TNZ , 7TO0 , 7TO1 , 7TO2 , 8DVR , 8DVS , 8DVU , 8G7T , 8G7U , 8G7V , 8SCZ , 8SD0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16739	CARD_2	1 → 93	Caspase recruitment domain	Domain
PF16739	CARD_2	99 → 190	Caspase recruitment domain	Domain
PF00270	DEAD	244 → 420	DEAD/DEAH box helicase	Domain
PF18119	RIG-I_C	457 → 602	RIG-I receptor C-terminal domain	Domain
PF00271	Helicase_C	609 → 734	Helicase conserved C-terminal domain	Family
PF11648	RIG-I_C-RD	806 → 923	C-terminal domain of RIG-I	Domain

Tissue specificity

TISSUE SPECIFICITY: Present in vascular smooth cells (at protein level). {ECO:0000269|PubMed:15219805}.

Sequence

MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKF
LLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIP
TDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERN
KFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSP
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI
PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTI
PSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNT
DEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMR
DTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFL
YTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGI
LTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGN
VIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKI
LHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKE
CFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAEMSK

Sequence length

925

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Hepatitis C Hepatitis B Measles Influenza A Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
RIGI-related disorder	Likely pathogenic	rs2489331579	RCV003410480
Singleton-Merten syndrome 2	Pathogenic; Likely pathogenic	rs786204847, rs786204848, rs1587586052	RCV000169760 RCV000169761 RCV000988170

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs61752945, rs138048526	RCV005907979 RCV005913519
Cholangiocarcinoma	Benign	rs10971002, rs61752945	RCV005932812 RCV005907983
Clear cell carcinoma of kidney	Uncertain significance; Benign	rs373568463, rs61752945	RCV005923913 RCV005907980
Gastric cancer	Likely benign	rs373199107	RCV005934761
Hepatocellular carcinoma	Benign	rs61752945	RCV005907977
Lung cancer	Benign	rs61752945	RCV005907984
Melanoma	Benign	rs61752945	RCV005907982
Nonpapillary renal cell carcinoma	Benign	rs61752945	RCV005907978
Sarcoma	Benign	rs10971002	RCV005932809
Thymoma	Benign	rs10971002	RCV005932811
Thyroid cancer, nonmedullary, 1	Benign	rs61752945, rs138048526	RCV005907981 RCV005913520
Uterine carcinosarcoma	Benign	rs10971002	RCV005932810
Uterine corpus endometrial carcinoma	Benign	rs10971002	RCV005932813

RIGI (RNA sensor RIG-I)