Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23586
Gene name Gene Name - the full gene name approved by the HGNC.
RNA sensor RIG-I
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RIGI
Synonyms (NCBI Gene) Gene synonyms aliases
DDX58, RIG-I, RIG1, RLR-1, SGMRT2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SGMRT2
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p21.1
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs786204847 T>G Pathogenic Coding sequence variant, missense variant
rs786204848 C>A Pathogenic Coding sequence variant, missense variant
rs1064795754 A>G Likely-pathogenic Coding sequence variant, missense variant
rs1131691305 A>G Likely-pathogenic Coding sequence variant, missense variant
rs1587586052 T>A Likely-pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT437784 hsa-miR-10b-5p Luciferase reporter assay 25312779
MIRT440833 hsa-miR-218-5p HITS-CLIP 23212916
MIRT440833 hsa-miR-218-5p HITS-CLIP 23212916
MIRT734373 hsa-miR-579-3p ELISA, Luciferase reporter assay, RNA-seq, Western blotting 32209695
MIRT734374 hsa-miR-221-3p ELISA, Luciferase reporter assay, RNA-seq, Western blotting 32209695
Transcription factors
Transcription factor Regulation Reference
IRF1 Activation 22391244
TRIM25 Unknown 21292167
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002230 Process Positive regulation of defense response to virus by host IMP 19609254
GO:0002735 Process Positive regulation of myeloid dendritic cell cytokine production ISS
GO:0003724 Function RNA helicase activity IEA
GO:0003725 Function Double-stranded RNA binding IBA 21873635
GO:0003725 Function Double-stranded RNA binding IDA 19576794
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609631 19102 ENSG00000107201
Protein
UniProt ID O95786
Protein name Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I prot
Protein function Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, Pu
PDB 2LWD , 2LWE , 2QFB , 2QFD , 2RMJ , 2YKG , 3LRN , 3LRR , 3NCU , 3OG8 , 3ZD6 , 3ZD7 , 4AY2 , 4BPB , 4NQK , 4ON9 , 4P4H , 5E3H , 5F98 , 5F9F , 5F9H , 6GPG , 6KYV , 7BAH , 7BAI , 7JL1 , 7JL3 , 7MK1 , 7TNX , 7TNY , 7TNZ , 7TO0 , 7TO1 , 7TO2 , 8DVR , 8DVS , 8DVU , 8G7T , 8G7U , 8G7V , 8SCZ , 8SD0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16739 CARD_2 1 93 Caspase recruitment domain Domain
PF16739 CARD_2 99 190 Caspase recruitment domain Domain
PF00270 DEAD 244 420 DEAD/DEAH box helicase Domain
PF18119 RIG-I_C 457 602 RIG-I receptor C-terminal domain Domain
PF00271 Helicase_C 609 734 Helicase conserved C-terminal domain Family
PF11648 RIG-I_C-RD 806 923 C-terminal domain of RIG-I Domain
Tissue specificity TISSUE SPECIFICITY: Present in vascular smooth cells (at protein level). {ECO:0000269|PubMed:15219805}.
Sequence
MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKF
LLELQEEGWFRGFLDALDHAGYSGLYEAIESWD
FKKIEKLEEYRLLLKRLQPEFKTRIIP
TDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERN
KFSELWIVEK
GIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSP
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQI
PVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTI
PSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNT

DEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMR
DTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFL
YTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SR
DPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGI
LTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGN
VIKMIQTRGRGRAR
GSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKI
LHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKE
CFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAEM
SK
Sequence length 925
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  NF-kappa B signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Coronavirus disease - COVID-19
  ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ub-specific processing proteases
Ovarian tumor domain proteases
OAS antiviral response
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glaucoma Glaucoma rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 25903422, 23143594, 25574825
Singleton merten syndrome Singleton Merten syndrome, SINGLETON-MERTEN SYNDROME 2, SINGLETON-MERTEN SYNDROME 1, Singleton-Merten dysplasia rs587777445, rs587777446, rs376048533, rs786204847, rs786204848, rs1587586052, rs1576226604, rs1576229572 25620203
Unknown
Disease term Disease name Evidence References Source
Singleton Merten Syndrome Singleton-Merten dysplasia, Singleton-Merten syndrome 2 GenCC
Psoriasis vulgaris Psoriasis vulgaris GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA