Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2358
Gene name Gene Name - the full gene name approved by the HGNC.
Formyl peptide receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FPR2
Synonyms (NCBI Gene) Gene synonyms aliases
ALX, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT619736 hsa-miR-125a-3p HITS-CLIP 23824327
MIRT619735 hsa-miR-764 HITS-CLIP 23824327
MIRT619734 hsa-miR-3934-5p HITS-CLIP 23824327
MIRT619733 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT619732 hsa-miR-1248 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IPI 11316806
GO:0001540 Function Amyloid-beta binding ISS
GO:0001774 Process Microglial cell activation ISS
GO:0001934 Process Positive regulation of protein phosphorylation IGI 20141570
GO:0002430 Process Complement receptor mediated signaling pathway IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
136538 3827 ENSG00000171049
Protein
UniProt ID P25090
Protein name N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP)
Protein function Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-prote
PDB 6LW5 , 6OMM , 7T6S , 7T6U , 7T6V , 7WVV , 7WVW , 7WVX , 7WVY , 8Y62 , 8Y63
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 43 302 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Detected in lung, bone marrow, neutrophils, spleen and testis. {ECO:0000269|PubMed:15465011, ECO:0000269|PubMed:9151906}.
Sequence
Sequence length 351
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Neutrophil extracellular trap formation
Staphylococcus aureus infection
  G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease, Regional enteritis 21659618 ClinVar
Alopecia Areata Alopecia Areata GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 31281837
Acute Disease Associate 39809189
Adenocarcinoma Inhibit 33120770
Adenocarcinoma of Lung Associate 32384511, 33120770, 36471379
Airway Obstruction Associate 29544524
Alzheimer Disease Associate 16212921, 20141570, 33804025, 33811735
Arrhythmogenic Right Ventricular Dysplasia Associate 30664203
Arthritis Associate 15171815, 15188355
Arthritis Rheumatoid Associate 15188355, 28316377
Asthma Inhibit 18583575