Gene Gene information from NCBI Gene database.
Entrez ID 2357
Gene name Formyl peptide receptor 1
Gene symbol FPR1
Synonyms (NCBI Gene)
FMLPFPR
Chromosome 19
Chromosome location 19q13.41
Summary This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in h
miRNA miRNA information provided by mirtarbase database.
198
miRTarBase ID miRNA Experiments Reference
MIRT018871 hsa-miR-335-5p Microarray 18185580
MIRT715707 hsa-miR-4722-3p HITS-CLIP 19536157
MIRT715708 hsa-miR-6727-3p HITS-CLIP 19536157
MIRT715706 hsa-miR-6747-3p HITS-CLIP 19536157
MIRT689335 hsa-miR-3653-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IDA 10823817
GO:0002430 Process Complement receptor mediated signaling pathway IBA
GO:0004875 Function Complement receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 15210802
GO:0004930 Function G protein-coupled receptor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
136537 3826 ENSG00000171051
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P21462
Protein name fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor)
Protein function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium
PDB 7EUO , 7T6T , 7VFX , 7WVU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 43 301 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Neutrophils.
Sequence
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Neutrophil extracellular trap formation
Staphylococcus aureus infection
  G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-10 signaling
Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
216
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
FPR1 POLYMORPHISM Benign rs5030880 RCV001035430
FPR1-related disorder Likely benign; Uncertain significance; Benign rs371692364, rs143583727, rs781400810, rs139480916, rs111768566, rs142210016, rs78488639, rs35264765, rs149931707, rs547725110 RCV003948420
RCV003898635
RCV004757611
RCV003924053
RCV003915486
RCV003905688
RCV003935753
RCV003905689
RCV003928434
RCV003930635
Gingival disorder Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity rs746593681, rs2083751098, rs143088639, rs555690623, rs775451540, rs2122320667, rs143583727, rs2122322070, rs145973159, rs2122322988, rs776424230, rs143480239, rs143690932, rs753449716, rs183314714
View all (176 more)
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RCV002242286
RCV002242267
RCV002242470
RCV002242582
RCV002242972
RCV002243024
RCV002243131
RCV002243074
RCV002242938
RCV002243057
RCV002242933
RCV002243107
RCV002237162
RCV002237151
RCV002236360
RCV002236354
RCV002237179
RCV002236171
RCV002240430
RCV002240275
RCV002240596
RCV002240447
RCV002240269
RCV002240663
RCV002240290
RCV002240295
RCV002239427
RCV002240883
RCV002240708
RCV002241020
RCV002240699
RCV002241173
RCV002241028
RCV002241006
RCV002241361
RCV002038943
RCV001984392
RCV001904956
RCV001920826
RCV001933254
RCV001905188
RCV001952305
RCV002017587
RCV002022574
RCV001947108
RCV002014626
RCV002014956
RCV001887401
RCV001922654
RCV002000260
RCV001899217
RCV001920168
RCV002037563
RCV002039306
RCV001906002
RCV002021212
RCV002090389
RCV002201995
RCV002216355
RCV002091140
RCV002135920
RCV002112250
RCV002096200
RCV002166174
RCV002170174
RCV002122150
RCV002149147
RCV002078779
RCV002301824
RCV002298332
RCV003068619
RCV003075961
RCV003081568
RCV003079987
RCV003090161
RCV002602621
RCV003090594
RCV002611677
RCV002620980
RCV003115321
RCV003112099
RCV003115790
RCV002786114
RCV002786194
RCV002775075
RCV002794937
RCV002811294
RCV002824851
RCV002835158
RCV002858710
RCV002880471
RCV002908358
RCV002938829
RCV002966373
RCV002975965
RCV002943690
RCV002942460
RCV002957971
RCV002995714
RCV002998791
RCV002994866
RCV003026308
RCV003596407
RCV003596451
RCV003596425
RCV003596432
RCV003596768
RCV003596803
RCV003596983
RCV003597014
RCV003596984
RCV003762276
RCV003762275
RCV003762326
RCV003762351
RCV003762474
RCV003762520
RCV003762656
RCV003762666
RCV003763356
RCV003763457
RCV003763506
RCV003763531
RCV003763476
RCV003763515
RCV003764224
RCV003763643
RCV003764389
RCV003764384
RCV003844329
RCV003840848
RCV003846913
RCV003855710
RCV003868914
RCV003874409
RCV003874421
RCV003870699
RCV003882470
RCV002230300
RCV002230302
RCV002230304
RCV002230301
RCV002230084
RCV002230303
RCV002231004
RCV002231221
RCV002231220
RCV002231222
RCV002231219
RCV002528851
RCV002234398
RCV002233923
RCV002234399
RCV002233924
RCV002234401
RCV002234400
RCV002233642
RCV002233629
RCV002233871
RCV002233855
RCV002235101
RCV002234904
RCV002235535
RCV002235323
RCV002235030
RCV002235094
RCV003596609
RCV002235844
RCV002235847
RCV002236048
RCV002235489
RCV002235612
RCV002235823
RCV002240319
RCV002239335
RCV002240323
RCV002239274
RCV002240341
RCV002237134
RCV002240186
RCV002240265
RCV002240490
RCV002239346
RCV002240536
RCV002239358
RCV002239298
RCV002239272
RCV002241311
RCV002241289
RCV002241128
RCV002241058
RCV002240973
RCV002241459
RCV002241487
RCV002241585
RCV002241504
RCV002563987
RCV002241628
RCV002241875
Periodontitis Uncertain significance rs747450344, rs1192119303 RCV000686521
RCV001223564
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acne Vulgaris Associate 31281837
Acute On Chronic Liver Failure Associate 33717119
Adenocarcinoma of Lung Associate 38213773
Aggressive Periodontitis Associate 19254133, 19722801
Airway Obstruction Associate 29544524
Aneurysm Ruptured Stimulate 32589050
Arrhythmogenic Right Ventricular Dysplasia Associate 30664203
Asthma Associate 33602227
Atherosclerosis Associate 39198660
Breast Neoplasms Associate 35045088, 35626741, 36970071