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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P21462 |
| Protein name |
fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) |
| Protein function |
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium |
| PDB |
7EUO
, 7T6T
, 7VFX
, 7WVU
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF00001 |
7tm_1 |
43 → 301 |
7 transmembrane receptor (rhodopsin family) |
Family |
|
| Tissue specificity |
TISSUE SPECIFICITY: Neutrophils. |
| Sequence |
|
| Sequence length |
350 |
| Interactions |
View interactions |
| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| FPR1 POLYMORPHISM |
Benign |
rs5030880 |
RCV001035430 |
| FPR1-related disorder |
Likely benign; Uncertain significance; Benign |
rs371692364, rs143583727, rs781400810, rs139480916, rs111768566, rs142210016, rs78488639, rs35264765, rs149931707, rs547725110 |
RCV003948420 RCV003898635 RCV004757611 RCV003924053 RCV003915486 RCV003905688 RCV003935753 RCV003905689 RCV003928434 RCV003930635 |
| Gingival disorder |
Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity |
rs746593681, rs2083751098, rs143088639, rs555690623, rs775451540, rs2122320667, rs143583727, rs2122322070, rs145973159, rs2122322988, rs776424230, rs143480239, rs143690932, rs753449716, rs183314714, rs539229723, rs148014099, rs371185306, rs771642804, rs150820622, rs375541232, rs766700447, rs148898220, rs2122323286, rs760563008, rs866728748, rs895586771, rs749154560, rs371692364, rs141229910, rs369805689, rs554681504, rs1471159412, rs199764870, rs1042229, rs2070745, rs2122323889, rs763819355, rs2083746822, rs2122323856, rs145808420, rs759165021, rs2122321483, rs564702916, rs200464393, rs145775814, rs757217120, rs571987775, rs764940294, rs1232982137, rs2122321274, rs376781635, rs371524501, rs2122322979, rs201110935, rs1197945289, rs778341723, rs748615602, rs753325158, rs539893573, rs762415254, rs769223294, rs1389132373, rs1848258347, rs1479199724, rs778269740, rs151277630, rs768152901, rs2513920095, rs2513921149, rs2513919130, rs1458825067, rs1358544550, rs1183171485, rs768554070, rs1431399661, rs547228145, rs1455632263, rs774585820, rs1197760903, rs754359145, rs1465049705, rs750811701, rs775825440, rs575255190, rs1460978960, rs1345865143, rs2513920994, rs750912266, rs2513919421, rs2513920562, rs1345693963, rs764738404, rs372037824, rs775026535, rs374349320, rs933017940, rs2083746036, rs889294894, rs201880162, rs2513921000, rs764370052, rs2513921312, rs757666229, rs1276303747, rs190373580, rs2083751604, rs2513920919, rs771713666, rs1369400642, rs1568637657, rs2083744874, rs2083744661, rs2513919953, rs750772517, rs2513919069, rs2513919529, rs2083747055, rs1253740709, rs1463080612, rs745998725, rs2513920375, rs2083748353, rs2513919514, rs781400810, rs903155050, rs2513920230, rs529498075, rs752024794, rs756459168, rs2513920216, rs1268054986, rs1290352179, rs867228, rs5030878, rs17849971, rs2070746, rs111768566, rs28930680, rs148095693, rs5030879, rs61736491, rs1555796329, rs1555796364, rs142210016, rs141913828, rs78488639, rs35264765, rs149382837, rs771446051, rs139132326, rs1302309228, rs139760904, rs146075164, rs771064181, rs186613919, rs750324912, rs199534146, rs371282377, rs150239733, rs149931707, rs547725110, rs145578657, rs747540806, rs1599806461, rs1599806193, rs201404212, rs2083741372, rs768241723, rs553738020, rs2083743451, rs368075541, rs1489945041, rs773162997, rs142367736, rs749737014, rs769777199, rs1284082601, rs5030880, rs2083742597, rs752836535, rs748893408, rs147646924, rs2083744471, rs140083445, rs2083741511, rs766818943, rs765164623, rs2083746502, rs138475342, rs551338523 View all (176 more) |
RCV002242167 RCV002242286 RCV002242267 RCV002242470 RCV002242582 RCV002242972 RCV002243024 RCV002243131 RCV002243074 RCV002242938 RCV002243057 RCV002242933 RCV002243107 RCV002237162 RCV002237151 RCV002236360 RCV002236354 RCV002237179 RCV002236171 RCV002240430 RCV002240275 RCV002240596 RCV002240447 RCV002240269 RCV002240663 RCV002240290 RCV002240295 RCV002239427 RCV002240883 RCV002240708 RCV002241020 RCV002240699 RCV002241173 RCV002241028 RCV002241006 RCV002241361 RCV002038943 RCV001984392 RCV001904956 RCV001920826 RCV001933254 RCV001905188 RCV001952305 RCV002017587 RCV002022574 RCV001947108 RCV002014626 RCV002014956 RCV001887401 RCV001922654 RCV002000260 RCV001899217 RCV001920168 RCV002037563 RCV002039306 RCV001906002 RCV002021212 RCV002090389 RCV002201995 RCV002216355 RCV002091140 RCV002135920 RCV002112250 RCV002096200 RCV002166174 RCV002170174 RCV002122150 RCV002149147 RCV002078779 RCV002301824 RCV002298332 RCV003068619 RCV003075961 RCV003081568 RCV003079987 RCV003090161 RCV002602621 RCV003090594 RCV002611677 RCV002620980 RCV003115321 RCV003112099 RCV003115790 RCV002786114 RCV002786194 RCV002775075 RCV002794937 RCV002811294 RCV002824851 RCV002835158 RCV002858710 RCV002880471 RCV002908358 RCV002938829 RCV002966373 RCV002975965 RCV002943690 RCV002942460 RCV002957971 RCV002995714 RCV002998791 RCV002994866 RCV003026308 RCV003596407 RCV003596451 RCV003596425 RCV003596432 RCV003596768 RCV003596803 RCV003596983 RCV003597014 RCV003596984 RCV003762276 RCV003762275 RCV003762326 RCV003762351 RCV003762474 RCV003762520 RCV003762656 RCV003762666 RCV003763356 RCV003763457 RCV003763506 RCV003763531 RCV003763476 RCV003763515 RCV003764224 RCV003763643 RCV003764389 RCV003764384 RCV003844329 RCV003840848 RCV003846913 RCV003855710 RCV003868914 RCV003874409 RCV003874421 RCV003870699 RCV003882470 RCV002230300 RCV002230302 RCV002230304 RCV002230301 RCV002230084 RCV002230303 RCV002231004 RCV002231221 RCV002231220 RCV002231222 RCV002231219 RCV002528851 RCV002234398 RCV002233923 RCV002234399 RCV002233924 RCV002234401 RCV002234400 RCV002233642 RCV002233629 RCV002233871 RCV002233855 RCV002235101 RCV002234904 RCV002235535 RCV002235323 RCV002235030 RCV002235094 RCV003596609 RCV002235844 RCV002235847 RCV002236048 RCV002235489 RCV002235612 RCV002235823 RCV002240319 RCV002239335 RCV002240323 RCV002239274 RCV002240341 RCV002237134 RCV002240186 RCV002240265 RCV002240490 RCV002239346 RCV002240536 RCV002239358 RCV002239298 RCV002239272 RCV002241311 RCV002241289 RCV002241128 RCV002241058 RCV002240973 RCV002241459 RCV002241487 RCV002241585 RCV002241504 RCV002563987 RCV002241628 RCV002241875 |
| Periodontitis |
Uncertain significance |
rs747450344, rs1192119303 |
RCV000686521 RCV001223564 |
| Prostate cancer |
Uncertain significance |
rs193920896 |
RCV000149096 |
|
| Disease Name |
Relationship Type |
References |
| Acne Vulgaris |
Associate |
31281837 |
| Acute On Chronic Liver Failure |
Associate |
33717119 |
| Adenocarcinoma of Lung |
Associate |
38213773 |
| Aggressive Periodontitis |
Associate |
19254133, 19722801 |
| Airway Obstruction |
Associate |
29544524 |
| Aneurysm Ruptured |
Stimulate |
32589050 |
| Arrhythmogenic Right Ventricular Dysplasia |
Associate |
30664203 |
| Asthma |
Associate |
33602227 |
| Atherosclerosis |
Associate |
39198660 |
| Breast Neoplasms |
Associate |
35045088, 35626741, 36970071 |
| Calcinosis Cutis |
Associate |
37245210 |
| Carcinoma Non Small Cell Lung |
Associate |
29313979 |
| Carcinoma Ovarian Epithelial |
Associate |
31703596 |
| Cardiovascular Diseases |
Associate |
39198660 |
| Cat Scratch Disease |
Associate |
20889801 |
| Choreoathetosis Hypothyroidism And Neonatal Respiratory Distress |
Associate |
35045088 |
| Ciliary Motility Disorders |
Associate |
29116124 |
| Colitis Ulcerative |
Associate |
35876170 |
| Colorectal Neoplasms |
Associate |
30649440 |
| COVID 19 |
Associate |
33138195, 34239034 |
| Crohn Disease |
Associate |
39475676 |
| Diabetes Mellitus |
Associate |
37773841 |
| Diabetes Mellitus Type 2 |
Associate |
39198660 |
| Down Syndrome |
Associate |
23891271 |
| Dyspnea |
Associate |
29544524 |
| Fetal Growth Retardation |
Associate |
35090410 |
| Fibrosis |
Associate |
33344044 |
| Glaucoma |
Associate |
15651980 |
| Glioma |
Associate |
38049523 |
| Graves Ophthalmopathy |
Associate |
37108173 |
| Hirschsprung Disease |
Associate |
36248794 |
| Idiopathic Interstitial Pneumonias |
Associate |
25058599 |
| Infections |
Associate |
11023526 |
| Inflammation |
Associate |
15210802, 22174875, 23637767, 25277308, 30826088, 31419078, 36970071, 38049523, 39253088 |
| Inflammation |
Stimulate |
32530982 |
| Inflammatory Bowel Diseases |
Associate |
35022690 |
| Intervertebral Disc Degeneration |
Associate |
36081453 |
| Intracranial Aneurysm |
Associate |
40389926 |
| Latent Infection |
Inhibit |
32971238 |
| Latent Tuberculosis |
Associate |
32971238 |
| Lung Injury |
Associate |
31419078 |
| Lung Neoplasms |
Associate |
29313979, 37073135 |
| Macular Degeneration |
Associate |
25277308 |
| Medulloblastoma |
Associate |
33345275 |
| Melanoma |
Associate |
29216889 |
| Myocardial Infarction |
Associate |
29381915, 32594092, 39198660 |
| Neoplasms |
Associate |
28986543, 33344044, 34026338, 35199442, 36970071, 37245210, 39198660 |
| Neoplasms |
Inhibit |
38115318 |
| Non alcoholic Fatty Liver Disease |
Associate |
32594092 |
| Osteosarcoma |
Associate |
40165145 |
| Ovarian Neoplasms |
Associate |
31703596, 33287740, 38115318 |
| Pancreatic Neoplasms |
Associate |
33353163 |
| Paraparesis Tropical Spastic |
Associate |
33632146 |
| Paroxysmal ventricular fibrillation |
Stimulate |
23891271 |
| Peri Implantitis |
Associate |
36412285 |
| Periodontitis |
Associate |
36412285 |
| Plague |
Associate |
33344044 |
| Pneumonia |
Associate |
33344044 |
| Polypoidal Choroidal Vasculopathy |
Associate |
25277308 |
| Premature Birth |
Associate |
15651980 |
| Protein Losing Enteropathies |
Associate |
25277308 |
| Pulmonary Disease Chronic Obstructive |
Associate |
29544524, 31419078 |
| Rectal Neoplasms |
Associate |
34026338, 37369459 |
| Renal Insufficiency Chronic |
Associate |
39253088 |
| Respiratory Distress Syndrome |
Associate |
39684262 |
| Rupture |
Associate |
36187340 |
| Sarcoma Kaposi |
Associate |
27681120 |
| Sleep Apnea Obstructive |
Associate |
31116781 |
| Smoke Inhalation Injury |
Associate |
33078507 |
| Stevens Johnson Syndrome |
Stimulate |
34193610 |
| Superinfection |
Associate |
22174875 |
| Tuberculosis |
Associate |
27941850, 32971238 |
| Tuberculosis Meningeal |
Inhibit |
32971238 |
| Tuberculosis Pulmonary |
Associate |
32971238 |
| Urinary Bladder Neoplasms |
Associate |
29665744, 34404901 |
|