Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2357
Gene name Gene Name - the full gene name approved by the HGNC.
Formyl peptide receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FPR1
Synonyms (NCBI Gene) Gene synonyms aliases
FMLP, FPR
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in h
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018871 hsa-miR-335-5p Microarray 18185580
MIRT715707 hsa-miR-4722-3p HITS-CLIP 19536157
MIRT715708 hsa-miR-6727-3p HITS-CLIP 19536157
MIRT715706 hsa-miR-6747-3p HITS-CLIP 19536157
MIRT689335 hsa-miR-3653-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IDA 10823817
GO:0002430 Process Complement receptor mediated signaling pathway IBA
GO:0004875 Function Complement receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 15210802
GO:0004930 Function G protein-coupled receptor activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
136537 3826 ENSG00000171051
Protein
UniProt ID P21462
Protein name fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor)
Protein function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:10514456, PubMed:15153520, PubMed:2161213, PubMed:2176894). Binding of fMLP to the receptor stimulates intracellular calcium
PDB 7EUO , 7T6T , 7VFX , 7WVU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 43 301 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Neutrophils.
Sequence
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Neutrophil extracellular trap formation
Staphylococcus aureus infection
  G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-10 signaling
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alopecia Areata Alopecia areata N/A N/A GWAS
Cervical Cancer Cervical cancer N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Periodontitis periodontitis, susceptibility to localized juvenile periodontitis N/A N/A ClinVar, GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acne Vulgaris Associate 31281837
Acute On Chronic Liver Failure Associate 33717119
Adenocarcinoma of Lung Associate 38213773
Aggressive Periodontitis Associate 19254133, 19722801
Airway Obstruction Associate 29544524
Aneurysm Ruptured Stimulate 32589050
Arrhythmogenic Right Ventricular Dysplasia Associate 30664203
Asthma Associate 33602227
Atherosclerosis Associate 39198660
Breast Neoplasms Associate 35045088, 35626741, 36970071