SLC16A8 (solute carrier family 16 member 8)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23539
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 16 member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC16A8
Synonyms (NCBI Gene) Gene synonyms aliases
MCT3, REMP
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 10493836
GO:0008028 Function Monocarboxylic acid transmembrane transporter activity IBA
GO:0008028 Function Monocarboxylic acid transmembrane transporter activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610409 16270 ENSG00000100156
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95907
Protein name Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8)
Protein function Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 20 → 329 Major Facilitator Superfamily Family
Tissue specificity TISSUE SPECIFICITY: Retinal pigment epithelium. {ECO:0000269|PubMed:10493836}.
Sequence
Sequence length 504
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Basigin interactions
Proton-coupled monocarboxylate transport
Pyruvate metabolism
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Glioma Glioma N/A N/A GWAS
Show/Hide Text Mining Associations (10)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 30535121
Carcinoma Renal Cell Associate 35456426
Colorectal Neoplasms Associate 36160034
Hereditary Breast and Ovarian Cancer Syndrome Associate 30535121
Macular Degeneration Associate 23455636, 30535121, 30934838, 32717343, 33477551, 34061866, 36036675, 37862026
Myopia Associate 30535121
Neoplasms Associate 30535121, 35456426
Neurodegenerative Diseases Associate 30535121
Parkinson Disease Associate 30535121
Schizophrenia Associate 30535121