NNT (nicotinamide nucleotide transhydrogenase)

Gene

• Entrez ID: 23530
• Gene name: Nicotinamide nucleotide transhydrogenase
• Gene symbol: NNT
• Synonyms (NCBI Gene): GCCD4
• Chromosome: 5
• Chromosome location: 5p12
• Summary: This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs370273690	T>C,G	Pathogenic	Missense variant, coding sequence variant, synonymous variant
rs387907232	C>T	Pathogenic	Coding sequence variant, missense variant
rs387907233	T>C	Pathogenic	Coding sequence variant, missense variant
rs387907234	G>C	Pathogenic	Coding sequence variant, missense variant
rs786205344	G>-	Pathogenic	Genic upstream transcript variant, splice acceptor variant
rs786205345	TCAC>-	Pathogenic	Coding sequence variant, frameshift variant, 5 prime UTR variant
rs864309519	->G	Pathogenic	Coding sequence variant, frameshift variant, 5 prime UTR variant
rs886039786	T>C	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs886039787	A>C	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant
rs886039788	G>A	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs886039789	C>G,T	Pathogenic	Genic upstream transcript variant, stop gained, missense variant, coding sequence variant, 5 prime UTR variant
rs886039790	C>T	Pathogenic	Intron variant, genic upstream transcript variant, stop gained, coding sequence variant, upstream transcript variant, 5 prime UTR variant
rs1579966821	->T	Likely-pathogenic	Genic upstream transcript variant, frameshift variant, coding sequence variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016790	hsa-miR-335-5p	Microarray	18185580
MIRT025238	hsa-miR-34a-5p	Proteomics	21566225
MIRT048367	hsa-miR-29b-3p	CLASH	23622248
MIRT046012	hsa-miR-125b-5p	CLASH	23622248
MIRT045755	hsa-miR-125a-5p	CLASH	23622248
MIRT044351	hsa-miR-106b-5p	CLASH	23622248
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT638501	hsa-miR-4255	HITS-CLIP	23824327
MIRT638500	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638498	hsa-miR-4289	HITS-CLIP	23824327
MIRT638499	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT638497	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638496	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT638495	hsa-miR-581	HITS-CLIP	23824327
MIRT638494	hsa-miR-3657	HITS-CLIP	23824327
MIRT638493	hsa-miR-4669	HITS-CLIP	23824327
MIRT638492	hsa-miR-2117	HITS-CLIP	23824327
MIRT638491	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT638490	hsa-miR-1260a	HITS-CLIP	23824327
MIRT638489	hsa-miR-1260b	HITS-CLIP	23824327
MIRT638488	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT638487	hsa-miR-592	HITS-CLIP	23824327
MIRT638486	hsa-miR-4273	HITS-CLIP	23824327
MIRT638485	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT627942	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT627941	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT627940	hsa-miR-4269	HITS-CLIP	23824327
MIRT627939	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT627938	hsa-miR-4514	HITS-CLIP	23824327
MIRT627937	hsa-miR-4692	HITS-CLIP	23824327
MIRT627936	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT627935	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT627934	hsa-miR-4518	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	21572407
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT518996	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT518995	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT518994	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT518993	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT518991	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT518990	hsa-miR-646	PAR-CLIP	21572407
MIRT518989	hsa-miR-501-5p	PAR-CLIP	21572407
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT518986	hsa-miR-107	PAR-CLIP	21572407
MIRT518985	hsa-miR-503-3p	PAR-CLIP	21572407
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	21572407
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	21572407
MIRT518976	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT518996	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT518995	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT518994	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT518993	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT518991	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT518990	hsa-miR-646	PAR-CLIP	23446348
MIRT518989	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT518986	hsa-miR-107	PAR-CLIP	23446348
MIRT518985	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	23446348
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	23446348
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	23446348
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	23446348
MIRT518976	hsa-miR-511-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	27292025
MIRT518986	hsa-miR-107	PAR-CLIP	27292025
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	27292025
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	27292025
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	27292025
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	27292025
MIRT518996	hsa-miR-16-5p	PAR-CLIP	27292025
MIRT518995	hsa-miR-195-5p	PAR-CLIP	27292025
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	27292025
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	27292025
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	27292025
MIRT518994	hsa-miR-424-5p	PAR-CLIP	27292025
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	27292025
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	27292025
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	27292025
MIRT518993	hsa-miR-497-5p	PAR-CLIP	27292025
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	27292025
MIRT518989	hsa-miR-501-5p	PAR-CLIP	27292025
MIRT518985	hsa-miR-503-3p	PAR-CLIP	27292025
MIRT518991	hsa-miR-503-5p	PAR-CLIP	27292025
MIRT518976	hsa-miR-511-5p	PAR-CLIP	27292025
MIRT518990	hsa-miR-646	PAR-CLIP	27292025
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	27292025
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	27292025
MIRT611906	hsa-miR-4672	HITS-CLIP	27418678
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	27418678
MIRT611909	hsa-miR-8485	HITS-CLIP	27418678
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT638501	hsa-miR-4255	HITS-CLIP	23824327
MIRT638500	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638498	hsa-miR-4289	HITS-CLIP	23824327
MIRT638499	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT638497	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638496	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT638495	hsa-miR-581	HITS-CLIP	23824327
MIRT638494	hsa-miR-3657	HITS-CLIP	23824327
MIRT638493	hsa-miR-4669	HITS-CLIP	23824327
MIRT638492	hsa-miR-2117	HITS-CLIP	23824327
MIRT638491	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT638490	hsa-miR-1260a	HITS-CLIP	23824327
MIRT638489	hsa-miR-1260b	HITS-CLIP	23824327
MIRT638488	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT638487	hsa-miR-592	HITS-CLIP	23824327
MIRT638486	hsa-miR-4273	HITS-CLIP	23824327
MIRT638485	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT627942	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT627941	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT627940	hsa-miR-4269	HITS-CLIP	23824327
MIRT627939	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT627938	hsa-miR-4514	HITS-CLIP	23824327
MIRT627937	hsa-miR-4692	HITS-CLIP	23824327
MIRT627936	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT627935	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT627934	hsa-miR-4518	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	21572407
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT518996	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT518995	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT518994	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT518993	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT518991	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT518990	hsa-miR-646	PAR-CLIP	21572407
MIRT518989	hsa-miR-501-5p	PAR-CLIP	21572407
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT518986	hsa-miR-107	PAR-CLIP	21572407
MIRT518985	hsa-miR-503-3p	PAR-CLIP	21572407
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	21572407
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	21572407
MIRT518976	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT518996	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT518995	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT518994	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT518993	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT518991	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT518990	hsa-miR-646	PAR-CLIP	23446348
MIRT518989	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT518986	hsa-miR-107	PAR-CLIP	23446348
MIRT518985	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	23446348
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	23446348
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	23446348
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	23446348
MIRT518976	hsa-miR-511-5p	PAR-CLIP	23446348
MIRT1188145	hsa-miR-1226	CLIP-seq
MIRT1188146	hsa-miR-409-5p	CLIP-seq
MIRT1188147	hsa-miR-4733-3p	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT1188149	hsa-miR-1278	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT1188155	hsa-miR-382	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT1188159	hsa-miR-4528	CLIP-seq
MIRT1188160	hsa-miR-4643	CLIP-seq
MIRT1188161	hsa-miR-466	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT1920686	hsa-miR-181a	CLIP-seq
MIRT1920687	hsa-miR-181b	CLIP-seq
MIRT1920688	hsa-miR-181c	CLIP-seq
MIRT1920689	hsa-miR-181d	CLIP-seq
MIRT1920690	hsa-miR-377	CLIP-seq
MIRT1920691	hsa-miR-4262	CLIP-seq
MIRT1920692	hsa-miR-496	CLIP-seq
MIRT1920693	hsa-miR-664	CLIP-seq
MIRT1920686	hsa-miR-181a	CLIP-seq
MIRT1920687	hsa-miR-181b	CLIP-seq
MIRT1920688	hsa-miR-181c	CLIP-seq
MIRT1920689	hsa-miR-181d	CLIP-seq
MIRT1920690	hsa-miR-377	CLIP-seq
MIRT1920691	hsa-miR-4262	CLIP-seq
MIRT1920692	hsa-miR-496	CLIP-seq
MIRT1920693	hsa-miR-664	CLIP-seq
MIRT2054528	hsa-miR-4668-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2283596	hsa-miR-23a	CLIP-seq
MIRT2283597	hsa-miR-23b	CLIP-seq
MIRT2283598	hsa-miR-23c	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2283600	hsa-miR-3671	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283604	hsa-miR-548v	CLIP-seq
MIRT2283605	hsa-miR-561	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2283607	hsa-miR-607	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2283600	hsa-miR-3671	CLIP-seq
MIRT2455280	hsa-miR-548n	CLIP-seq
MIRT2455281	hsa-miR-548t	CLIP-seq
MIRT2283605	hsa-miR-561	CLIP-seq
MIRT2283607	hsa-miR-607	CLIP-seq
MIRT2581781	hsa-miR-105	CLIP-seq
MIRT2581782	hsa-miR-1244	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT2581783	hsa-miR-1272	CLIP-seq
MIRT2581784	hsa-miR-1284	CLIP-seq
MIRT2581785	hsa-miR-129-5p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2581786	hsa-miR-142-5p	CLIP-seq
MIRT2581787	hsa-miR-203	CLIP-seq
MIRT2581788	hsa-miR-216b	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT2581789	hsa-miR-3064-3p	CLIP-seq
MIRT2581790	hsa-miR-3126-5p	CLIP-seq
MIRT2581791	hsa-miR-3140-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT2581792	hsa-miR-3160-5p	CLIP-seq
MIRT2581793	hsa-miR-3174	CLIP-seq
MIRT2581794	hsa-miR-3180-5p	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2581795	hsa-miR-338-3p	CLIP-seq
MIRT2581796	hsa-miR-340	CLIP-seq
MIRT2581797	hsa-miR-3613-3p	CLIP-seq
MIRT2581798	hsa-miR-3614-5p	CLIP-seq
MIRT2581799	hsa-miR-3617	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT2581800	hsa-miR-3921	CLIP-seq
MIRT2581801	hsa-miR-409-3p	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2581802	hsa-miR-4282	CLIP-seq
MIRT2581803	hsa-miR-4328	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT2581804	hsa-miR-4419a	CLIP-seq
MIRT2581805	hsa-miR-4422	CLIP-seq
MIRT2581806	hsa-miR-4510	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT2581807	hsa-miR-4530	CLIP-seq
MIRT2581808	hsa-miR-4540	CLIP-seq
MIRT2581809	hsa-miR-455-5p	CLIP-seq
MIRT2581810	hsa-miR-4653-5p	CLIP-seq
MIRT2581811	hsa-miR-4659a-3p	CLIP-seq
MIRT2581812	hsa-miR-4659b-3p	CLIP-seq
MIRT2581813	hsa-miR-4680-5p	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT2581814	hsa-miR-4766-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT2581815	hsa-miR-4780	CLIP-seq
MIRT2581816	hsa-miR-494	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2581817	hsa-miR-500a	CLIP-seq
MIRT2581818	hsa-miR-501-3p	CLIP-seq
MIRT2581819	hsa-miR-502-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT2581820	hsa-miR-539	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2581821	hsa-miR-582-5p	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2581822	hsa-miR-640	CLIP-seq
MIRT2581823	hsa-miR-641	CLIP-seq
MIRT2581824	hsa-miR-921	CLIP-seq
MIRT2581825	hsa-miR-938	CLIP-seq
MIRT2581781	hsa-miR-105	CLIP-seq
MIRT2581782	hsa-miR-1244	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT2581783	hsa-miR-1272	CLIP-seq
MIRT2581784	hsa-miR-1284	CLIP-seq
MIRT2581785	hsa-miR-129-5p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2581786	hsa-miR-142-5p	CLIP-seq
MIRT2581787	hsa-miR-203	CLIP-seq
MIRT2581788	hsa-miR-216b	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT2581789	hsa-miR-3064-3p	CLIP-seq
MIRT2581790	hsa-miR-3126-5p	CLIP-seq
MIRT2581791	hsa-miR-3140-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT2581792	hsa-miR-3160-5p	CLIP-seq
MIRT2581793	hsa-miR-3174	CLIP-seq
MIRT2581794	hsa-miR-3180-5p	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2581795	hsa-miR-338-3p	CLIP-seq
MIRT2581796	hsa-miR-340	CLIP-seq
MIRT2581797	hsa-miR-3613-3p	CLIP-seq
MIRT2581798	hsa-miR-3614-5p	CLIP-seq
MIRT2581799	hsa-miR-3617	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT2581800	hsa-miR-3921	CLIP-seq
MIRT2581801	hsa-miR-409-3p	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2581802	hsa-miR-4282	CLIP-seq
MIRT2581803	hsa-miR-4328	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT2581804	hsa-miR-4419a	CLIP-seq
MIRT2581805	hsa-miR-4422	CLIP-seq
MIRT2686408	hsa-miR-4436b-5p	CLIP-seq
MIRT2686409	hsa-miR-4452	CLIP-seq
MIRT2581806	hsa-miR-4510	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT2581807	hsa-miR-4530	CLIP-seq
MIRT2581808	hsa-miR-4540	CLIP-seq
MIRT2581809	hsa-miR-455-5p	CLIP-seq
MIRT2581810	hsa-miR-4653-5p	CLIP-seq
MIRT2581811	hsa-miR-4659a-3p	CLIP-seq
MIRT2581812	hsa-miR-4659b-3p	CLIP-seq
MIRT2581813	hsa-miR-4680-5p	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT2581814	hsa-miR-4766-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT2581815	hsa-miR-4780	CLIP-seq
MIRT2581816	hsa-miR-494	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2581817	hsa-miR-500a	CLIP-seq
MIRT2581818	hsa-miR-501-3p	CLIP-seq
MIRT2581819	hsa-miR-502-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT2581820	hsa-miR-539	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2581821	hsa-miR-582-5p	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2581822	hsa-miR-640	CLIP-seq
MIRT2581823	hsa-miR-641	CLIP-seq
MIRT2686410	hsa-miR-653	CLIP-seq
MIRT2686411	hsa-miR-889	CLIP-seq
MIRT2581824	hsa-miR-921	CLIP-seq
MIRT2581825	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003957	Function	NAD(P)+ transhydrogenase (Si-specific) activity	TAS	9524818
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS	10673423
GO:0006099	Process	Tricarboxylic acid cycle	TAS	10673423
GO:0006740	Process	NADPH regeneration	IBA
GO:0006740	Process	NADPH regeneration	IEA
GO:0008750	Function	Proton-translocating NAD(P)+ transhydrogenase activity	IEA
GO:0010918	Process	Positive regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032364	Process	Intracellular oxygen homeostasis	IEA
GO:0033273	Process	Response to vitamin	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	IDA	10673423
GO:0051287	Function	NAD binding	TAS	10673423
GO:0072593	Process	Reactive oxygen species metabolic process	IMP	22634753
GO:0098803	Component	Respiratory chain complex	TAS	10673423
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	TAS	10673423
GO:1903285	Process	Positive regulation of hydrogen peroxide catabolic process	IEA

Other IDs

• MIM: 607878
• HGNC: 7863
• e!Ensembl: ENSG00000112992

Protein

• UniProt ID: Q13423
• Protein name: NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)
• Protein function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (P
• PDB: 1DJL, 1PT9, 1U31
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05222	AlaDh_PNT_N	60 → 199	Alanine dehydrogenase/PNT, N-terminal domain	Domain
  PF01262	AlaDh_PNT_C	203 → 437	Alanine dehydrogenase/PNT, C-terminal domain	Domain
  PF12769	PNTB_4TM	501 → 587	4TM region of pyridine nucleotide transhydrogenase, mitoch	Family
  PF02233	PNTB	620 → 1079	NAD(P) transhydrogenase beta subunit	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.
• Sequence:

  MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVG
  VPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVL
  ASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQV
  PRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGL
  ASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAE
  MKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPG
  ELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMG
  HVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYT
  AGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAV
  GGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLL
  PAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLA
  ATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIA
  EYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLL
  NAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNS
  YSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGG
  KPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRF
  GIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDP
  NSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKV
  RESYQK

• Sequence length: 1086

Pathways

KEGG:

Nicotinate and nicotinamide metabolism
Metabolic pathways

Reactome:

Citric acid cycle (TCA cycle)

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Glucocorticoid deficiency 4	Pathogenic; Likely pathogenic	rs2111935997, rs2478489596, rs1437719035, rs864309519, rs886039786, rs886039788, rs886039789, rs886039790, rs2478488956, rs387907232, rs786205344, rs387907233, rs786205345, rs370273690, rs387907234, rs1579966821, rs1739624229	RCV001449919 RCV002283609 RCV002283833 RCV000202606 RCV000256214 RCV001254595 RCV000256222 RCV000256229 RCV004545904 RCV000029193 RCV000029194 RCV000029195 RCV000029196 RCV000029197 RCV000029198 RCV000985151 RCV001196318
GLUCOCORTICOID DEFICIENCY 4 WITH MINERALOCORTICOID DEFICIENCY	Pathogenic; Likely pathogenic	rs886039787, rs886039788	RCV000256221 RCV000256216

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs114002702	RCV005907175
Familial cancer of breast	Benign	rs114002702	RCV005907174
Gastric cancer	Benign	rs34241095	RCV005907149
Malignant tumor of esophagus	Benign	rs34241095	RCV005907148
NNT-related disorder	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign; Benign	rs139947920, rs370370846, rs371081845, rs150910464, rs377592942, rs367558397, rs200074849, rs138669858, rs372097869, rs970172922, rs141100202, rs757592133, rs769982417, rs201576637, rs775846521, rs372737896, rs370270976, rs781393398, rs367613933, rs113092064, rs190213776, rs139893206	RCV003948713 RCV003401997 RCV003892934 RCV003933481 RCV003933635 RCV003396895 RCV003973487 RCV003963348 RCV003943531 RCV003410498 RCV003929283 RCV003921529 RCV003919780 RCV003904605 RCV003919468 RCV003927174 RCV003967074 RCV003968933 RCV003967930 RCV003920429 RCV003925861 RCV003936221
Sarcoma	Benign	rs114002702	RCV005907176
See cases	Uncertain significance	rs1051148310	RCV002252600

Associations from Text Mining
Disease Name	Relationship Type	References
Addison Disease	Associate	27129361, 34193132, 35627102
Adrenal Insufficiency	Associate	27129361
Alzheimer Disease	Associate	29186589
Bone Diseases Metabolic	Associate	35627102
Breast Neoplasms	Associate	32190687
Carcinoma Renal Cell	Associate	38036719
Cardiomyopathy Hypertrophic	Associate	27129361
Cognition Disorders	Associate	29186589
Congenital Hypothyroidism	Associate	27129361
Cryptorchidism	Associate	27129361
Cystic Fibrosis	Associate	33478087
Diabetes Mellitus	Associate	27459240
Drug Related Side Effects and Adverse Reactions	Inhibit	32187573
Familial Glucocorticoid Deficiency 1	Associate	25459914, 27129361, 35627102
Glioma	Associate	27560795, 31734653
Glucocorticoid Deficiency 2	Associate	23474776, 25459914, 27129361, 27459240
Glucose Intolerance	Associate	23592659
Hearing Loss	Associate	36656851
Heart Failure	Associate	20388492, 27459240
Hypoglycemia	Associate	27129361
Hypothyroidism	Associate	27129361
Hypoxia	Stimulate	27560795
Hypoxia Brain	Associate	27560795
Inflammation	Associate	30823587
Intestinal Pseudo Obstruction	Associate	23592659
Isolated Noncompaction of the Ventricular Myocardium	Associate	27459240
Mineralocorticoid Deficiency Isolated	Associate	27129361
Mitochondrial Diseases	Associate	27459240
Neoplasms	Associate	32187573, 35715447, 37244254
Obesity	Associate	23592659, 27459240
Obesity	Inhibit	30823587
Paraganglioma Extra Adrenal	Associate	27129361
Prostatic Neoplasms	Associate	35715447
Stomach Neoplasms	Associate	37244254
Taste Disorders	Associate	34193132
Triple Negative Breast Neoplasms	Associate	32190687
Uterine Cervical Neoplasms	Associate	18559093