Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23530
Gene name Gene Name - the full gene name approved by the HGNC.	Nicotinamide nucleotide transhydrogenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NNT
Synonyms (NCBI Gene) Gene synonyms aliases	GCCD4
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses

Show/Hide all(13)

SNP ID	Visualize variation	Clinical significance	Consequence
rs370273690	T>C,G	Pathogenic	Missense variant, coding sequence variant, synonymous variant
rs387907232	C>T	Pathogenic	Coding sequence variant, missense variant
rs387907233	T>C	Pathogenic	Coding sequence variant, missense variant
rs387907234	G>C	Pathogenic	Coding sequence variant, missense variant
rs786205344	G>-	Pathogenic	Genic upstream transcript variant, splice acceptor variant
rs786205345	TCAC>-	Pathogenic	Coding sequence variant, frameshift variant, 5 prime UTR variant
rs864309519	->G	Pathogenic	Coding sequence variant, frameshift variant, 5 prime UTR variant
rs886039786	T>C	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs886039787	A>C	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant
rs886039788	G>A	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant, genic upstream transcript variant
rs886039789	C>G,T	Pathogenic	Genic upstream transcript variant, stop gained, missense variant, coding sequence variant, 5 prime UTR variant
rs886039790	C>T	Pathogenic	Intron variant, genic upstream transcript variant, stop gained, coding sequence variant, upstream transcript variant, 5 prime UTR variant
rs1579966821	->T	Likely-pathogenic	Genic upstream transcript variant, frameshift variant, coding sequence variant, 5 prime UTR variant

Show/Hide all(507)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016790	hsa-miR-335-5p	Microarray	18185580
MIRT025238	hsa-miR-34a-5p	Proteomics	21566225
MIRT048367	hsa-miR-29b-3p	CLASH	23622248
MIRT046012	hsa-miR-125b-5p	CLASH	23622248
MIRT045755	hsa-miR-125a-5p	CLASH	23622248
MIRT044351	hsa-miR-106b-5p	CLASH	23622248
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT638501	hsa-miR-4255	HITS-CLIP	23824327
MIRT638500	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638498	hsa-miR-4289	HITS-CLIP	23824327
MIRT638499	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT638497	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638496	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT638495	hsa-miR-581	HITS-CLIP	23824327
MIRT638494	hsa-miR-3657	HITS-CLIP	23824327
MIRT638493	hsa-miR-4669	HITS-CLIP	23824327
MIRT638492	hsa-miR-2117	HITS-CLIP	23824327
MIRT638491	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT638490	hsa-miR-1260a	HITS-CLIP	23824327
MIRT638489	hsa-miR-1260b	HITS-CLIP	23824327
MIRT638488	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT638487	hsa-miR-592	HITS-CLIP	23824327
MIRT638486	hsa-miR-4273	HITS-CLIP	23824327
MIRT638485	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT627942	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT627941	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT627940	hsa-miR-4269	HITS-CLIP	23824327
MIRT627939	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT627938	hsa-miR-4514	HITS-CLIP	23824327
MIRT627937	hsa-miR-4692	HITS-CLIP	23824327
MIRT627936	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT627935	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT627934	hsa-miR-4518	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	21572407
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT518996	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT518995	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT518994	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT518993	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT518991	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT518990	hsa-miR-646	PAR-CLIP	21572407
MIRT518989	hsa-miR-501-5p	PAR-CLIP	21572407
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT518986	hsa-miR-107	PAR-CLIP	21572407
MIRT518985	hsa-miR-503-3p	PAR-CLIP	21572407
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	21572407
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	21572407
MIRT518976	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT518996	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT518995	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT518994	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT518993	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT518991	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT518990	hsa-miR-646	PAR-CLIP	23446348
MIRT518989	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT518986	hsa-miR-107	PAR-CLIP	23446348
MIRT518985	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	23446348
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	23446348
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	23446348
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	23446348
MIRT518976	hsa-miR-511-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	27292025
MIRT518986	hsa-miR-107	PAR-CLIP	27292025
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	27292025
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	27292025
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	27292025
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	27292025
MIRT518996	hsa-miR-16-5p	PAR-CLIP	27292025
MIRT518995	hsa-miR-195-5p	PAR-CLIP	27292025
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	27292025
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	27292025
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	27292025
MIRT518994	hsa-miR-424-5p	PAR-CLIP	27292025
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	27292025
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	27292025
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	27292025
MIRT518993	hsa-miR-497-5p	PAR-CLIP	27292025
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	27292025
MIRT518989	hsa-miR-501-5p	PAR-CLIP	27292025
MIRT518985	hsa-miR-503-3p	PAR-CLIP	27292025
MIRT518991	hsa-miR-503-5p	PAR-CLIP	27292025
MIRT518976	hsa-miR-511-5p	PAR-CLIP	27292025
MIRT518990	hsa-miR-646	PAR-CLIP	27292025
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	27292025
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	27292025
MIRT611906	hsa-miR-4672	HITS-CLIP	27418678
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	27418678
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	27418678
MIRT611909	hsa-miR-8485	HITS-CLIP	27418678
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT518989	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT638501	hsa-miR-4255	HITS-CLIP	23824327
MIRT638500	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638498	hsa-miR-4289	HITS-CLIP	23824327
MIRT638499	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT638497	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638496	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT638495	hsa-miR-581	HITS-CLIP	23824327
MIRT638494	hsa-miR-3657	HITS-CLIP	23824327
MIRT638493	hsa-miR-4669	HITS-CLIP	23824327
MIRT638492	hsa-miR-2117	HITS-CLIP	23824327
MIRT638491	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT638490	hsa-miR-1260a	HITS-CLIP	23824327
MIRT638489	hsa-miR-1260b	HITS-CLIP	23824327
MIRT638488	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT638487	hsa-miR-592	HITS-CLIP	23824327
MIRT638486	hsa-miR-4273	HITS-CLIP	23824327
MIRT638485	hsa-miR-7156-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT627945	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT627944	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT627943	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT627942	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT627941	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT627940	hsa-miR-4269	HITS-CLIP	23824327
MIRT627939	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT627938	hsa-miR-4514	HITS-CLIP	23824327
MIRT627937	hsa-miR-4692	HITS-CLIP	23824327
MIRT627936	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT627935	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT627934	hsa-miR-4518	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT623067	hsa-miR-1305	HITS-CLIP	23824327
MIRT611909	hsa-miR-8485	HITS-CLIP	23824327
MIRT611908	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT611907	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611906	hsa-miR-4672	HITS-CLIP	23824327
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	21572407
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT518996	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT518995	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT518994	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT518993	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT518991	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT518990	hsa-miR-646	PAR-CLIP	21572407
MIRT518989	hsa-miR-501-5p	PAR-CLIP	21572407
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT518986	hsa-miR-107	PAR-CLIP	21572407
MIRT518985	hsa-miR-503-3p	PAR-CLIP	21572407
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	21572407
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	21572407
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	21572407
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	21572407
MIRT518976	hsa-miR-511-5p	PAR-CLIP	21572407
MIRT518999	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT518998	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT518997	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT518996	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT518995	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT518994	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT518993	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT518992	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT518991	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT518990	hsa-miR-646	PAR-CLIP	23446348
MIRT518989	hsa-miR-501-5p	PAR-CLIP	23446348
MIRT518988	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT518987	hsa-miR-103a-3p	PAR-CLIP	23446348
MIRT518986	hsa-miR-107	PAR-CLIP	23446348
MIRT518985	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT518984	hsa-miR-6830-3p	PAR-CLIP	23446348
MIRT518983	hsa-miR-4711-3p	PAR-CLIP	23446348
MIRT518982	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT518981	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT518980	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT518979	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT518978	hsa-miR-1225-5p	PAR-CLIP	23446348
MIRT518977	hsa-miR-1229-5p	PAR-CLIP	23446348
MIRT518976	hsa-miR-511-5p	PAR-CLIP	23446348
MIRT1188145	hsa-miR-1226	CLIP-seq
MIRT1188146	hsa-miR-409-5p	CLIP-seq
MIRT1188147	hsa-miR-4733-3p	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT1188149	hsa-miR-1278	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT1188155	hsa-miR-382	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT1188159	hsa-miR-4528	CLIP-seq
MIRT1188160	hsa-miR-4643	CLIP-seq
MIRT1188161	hsa-miR-466	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT1920686	hsa-miR-181a	CLIP-seq
MIRT1920687	hsa-miR-181b	CLIP-seq
MIRT1920688	hsa-miR-181c	CLIP-seq
MIRT1920689	hsa-miR-181d	CLIP-seq
MIRT1920690	hsa-miR-377	CLIP-seq
MIRT1920691	hsa-miR-4262	CLIP-seq
MIRT1920692	hsa-miR-496	CLIP-seq
MIRT1920693	hsa-miR-664	CLIP-seq
MIRT1920686	hsa-miR-181a	CLIP-seq
MIRT1920687	hsa-miR-181b	CLIP-seq
MIRT1920688	hsa-miR-181c	CLIP-seq
MIRT1920689	hsa-miR-181d	CLIP-seq
MIRT1920690	hsa-miR-377	CLIP-seq
MIRT1920691	hsa-miR-4262	CLIP-seq
MIRT1920692	hsa-miR-496	CLIP-seq
MIRT1920693	hsa-miR-664	CLIP-seq
MIRT2054528	hsa-miR-4668-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2283596	hsa-miR-23a	CLIP-seq
MIRT2283597	hsa-miR-23b	CLIP-seq
MIRT2283598	hsa-miR-23c	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2283600	hsa-miR-3671	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283604	hsa-miR-548v	CLIP-seq
MIRT2283605	hsa-miR-561	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2283607	hsa-miR-607	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2283600	hsa-miR-3671	CLIP-seq
MIRT2455280	hsa-miR-548n	CLIP-seq
MIRT2455281	hsa-miR-548t	CLIP-seq
MIRT2283605	hsa-miR-561	CLIP-seq
MIRT2283607	hsa-miR-607	CLIP-seq
MIRT2581781	hsa-miR-105	CLIP-seq
MIRT2581782	hsa-miR-1244	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT2581783	hsa-miR-1272	CLIP-seq
MIRT2581784	hsa-miR-1284	CLIP-seq
MIRT2581785	hsa-miR-129-5p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2581786	hsa-miR-142-5p	CLIP-seq
MIRT2581787	hsa-miR-203	CLIP-seq
MIRT2581788	hsa-miR-216b	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT2581789	hsa-miR-3064-3p	CLIP-seq
MIRT2581790	hsa-miR-3126-5p	CLIP-seq
MIRT2581791	hsa-miR-3140-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT2581792	hsa-miR-3160-5p	CLIP-seq
MIRT2581793	hsa-miR-3174	CLIP-seq
MIRT2581794	hsa-miR-3180-5p	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2581795	hsa-miR-338-3p	CLIP-seq
MIRT2581796	hsa-miR-340	CLIP-seq
MIRT2581797	hsa-miR-3613-3p	CLIP-seq
MIRT2581798	hsa-miR-3614-5p	CLIP-seq
MIRT2581799	hsa-miR-3617	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT2581800	hsa-miR-3921	CLIP-seq
MIRT2581801	hsa-miR-409-3p	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2581802	hsa-miR-4282	CLIP-seq
MIRT2581803	hsa-miR-4328	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT2581804	hsa-miR-4419a	CLIP-seq
MIRT2581805	hsa-miR-4422	CLIP-seq
MIRT2581806	hsa-miR-4510	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT2581807	hsa-miR-4530	CLIP-seq
MIRT2581808	hsa-miR-4540	CLIP-seq
MIRT2581809	hsa-miR-455-5p	CLIP-seq
MIRT2581810	hsa-miR-4653-5p	CLIP-seq
MIRT2581811	hsa-miR-4659a-3p	CLIP-seq
MIRT2581812	hsa-miR-4659b-3p	CLIP-seq
MIRT2581813	hsa-miR-4680-5p	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT2581814	hsa-miR-4766-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT2581815	hsa-miR-4780	CLIP-seq
MIRT2581816	hsa-miR-494	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2581817	hsa-miR-500a	CLIP-seq
MIRT2581818	hsa-miR-501-3p	CLIP-seq
MIRT2581819	hsa-miR-502-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT2581820	hsa-miR-539	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2581821	hsa-miR-582-5p	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2581822	hsa-miR-640	CLIP-seq
MIRT2581823	hsa-miR-641	CLIP-seq
MIRT2581824	hsa-miR-921	CLIP-seq
MIRT2581825	hsa-miR-938	CLIP-seq
MIRT2581781	hsa-miR-105	CLIP-seq
MIRT2581782	hsa-miR-1244	CLIP-seq
MIRT1188148	hsa-miR-1256	CLIP-seq
MIRT2581783	hsa-miR-1272	CLIP-seq
MIRT2581784	hsa-miR-1284	CLIP-seq
MIRT2581785	hsa-miR-129-5p	CLIP-seq
MIRT1188150	hsa-miR-1323	CLIP-seq
MIRT2581786	hsa-miR-142-5p	CLIP-seq
MIRT2581787	hsa-miR-203	CLIP-seq
MIRT2581788	hsa-miR-216b	CLIP-seq
MIRT1188151	hsa-miR-2467-3p	CLIP-seq
MIRT2581789	hsa-miR-3064-3p	CLIP-seq
MIRT2581790	hsa-miR-3126-5p	CLIP-seq
MIRT2581791	hsa-miR-3140-3p	CLIP-seq
MIRT1188152	hsa-miR-3152-5p	CLIP-seq
MIRT1188153	hsa-miR-3158-5p	CLIP-seq
MIRT2581792	hsa-miR-3160-5p	CLIP-seq
MIRT2581793	hsa-miR-3174	CLIP-seq
MIRT2581794	hsa-miR-3180-5p	CLIP-seq
MIRT2283599	hsa-miR-335	CLIP-seq
MIRT2581795	hsa-miR-338-3p	CLIP-seq
MIRT2581796	hsa-miR-340	CLIP-seq
MIRT2581797	hsa-miR-3613-3p	CLIP-seq
MIRT2581798	hsa-miR-3614-5p	CLIP-seq
MIRT2581799	hsa-miR-3617	CLIP-seq
MIRT1188154	hsa-miR-3678-3p	CLIP-seq
MIRT2581800	hsa-miR-3921	CLIP-seq
MIRT2581801	hsa-miR-409-3p	CLIP-seq
MIRT1188156	hsa-miR-4257	CLIP-seq
MIRT2581802	hsa-miR-4282	CLIP-seq
MIRT2581803	hsa-miR-4328	CLIP-seq
MIRT1188157	hsa-miR-4418	CLIP-seq
MIRT2581804	hsa-miR-4419a	CLIP-seq
MIRT2581805	hsa-miR-4422	CLIP-seq
MIRT2686408	hsa-miR-4436b-5p	CLIP-seq
MIRT2686409	hsa-miR-4452	CLIP-seq
MIRT2581806	hsa-miR-4510	CLIP-seq
MIRT1188158	hsa-miR-4522	CLIP-seq
MIRT2581807	hsa-miR-4530	CLIP-seq
MIRT2581808	hsa-miR-4540	CLIP-seq
MIRT2581809	hsa-miR-455-5p	CLIP-seq
MIRT2581810	hsa-miR-4653-5p	CLIP-seq
MIRT2581811	hsa-miR-4659a-3p	CLIP-seq
MIRT2581812	hsa-miR-4659b-3p	CLIP-seq
MIRT2581813	hsa-miR-4680-5p	CLIP-seq
MIRT1188162	hsa-miR-4714-5p	CLIP-seq
MIRT2581814	hsa-miR-4766-5p	CLIP-seq
MIRT1188163	hsa-miR-4774-3p	CLIP-seq
MIRT2581815	hsa-miR-4780	CLIP-seq
MIRT2581816	hsa-miR-494	CLIP-seq
MIRT2283601	hsa-miR-499-3p	CLIP-seq
MIRT2283602	hsa-miR-499a-3p	CLIP-seq
MIRT2581817	hsa-miR-500a	CLIP-seq
MIRT2581818	hsa-miR-501-3p	CLIP-seq
MIRT2581819	hsa-miR-502-3p	CLIP-seq
MIRT1188164	hsa-miR-509-3-5p	CLIP-seq
MIRT1188165	hsa-miR-509-5p	CLIP-seq
MIRT2283603	hsa-miR-515-5p	CLIP-seq
MIRT2581820	hsa-miR-539	CLIP-seq
MIRT1188166	hsa-miR-548a-3p	CLIP-seq
MIRT2054529	hsa-miR-548c-3p	CLIP-seq
MIRT1188167	hsa-miR-548e	CLIP-seq
MIRT1188168	hsa-miR-548f	CLIP-seq
MIRT1188169	hsa-miR-548o	CLIP-seq
MIRT2283606	hsa-miR-579	CLIP-seq
MIRT2581821	hsa-miR-582-5p	CLIP-seq
MIRT2283608	hsa-miR-622	CLIP-seq
MIRT2581822	hsa-miR-640	CLIP-seq
MIRT2581823	hsa-miR-641	CLIP-seq
MIRT2686410	hsa-miR-653	CLIP-seq
MIRT2686411	hsa-miR-889	CLIP-seq
MIRT2581824	hsa-miR-921	CLIP-seq
MIRT2581825	hsa-miR-938	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003957	Function	NAD(P)+ transhydrogenase (Si-specific) activity	TAS	9524818
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS	10673423
GO:0006099	Process	Tricarboxylic acid cycle	TAS	10673423
GO:0006740	Process	NADPH regeneration	IBA
GO:0006740	Process	NADPH regeneration	IEA
GO:0008750	Function	Proton-translocating NAD(P)+ transhydrogenase activity	IEA
GO:0010918	Process	Positive regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032364	Process	Intracellular oxygen homeostasis	IEA
GO:0033273	Process	Response to vitamin	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	IDA	10673423
GO:0051287	Function	NAD binding	TAS	10673423
GO:0072593	Process	Reactive oxygen species metabolic process	IMP	22634753
GO:0098803	Component	Respiratory chain complex	TAS	10673423
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	TAS	10673423
GO:1903285	Process	Positive regulation of hydrogen peroxide catabolic process	IEA

MIM	HGNC	e!Ensembl
607878	7863	ENSG00000112992

Protein

UniProt ID

Q13423

Protein name

NAD(P) transhydrogenase, mitochondrial (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)

Protein function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (P

PDB

1DJL , 1PT9 , 1U31

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05222	AlaDh_PNT_N	60 → 199	Alanine dehydrogenase/PNT, N-terminal domain	Domain
PF01262	AlaDh_PNT_C	203 → 437	Alanine dehydrogenase/PNT, C-terminal domain	Domain
PF12769	PNTB_4TM	501 → 587	4TM region of pyridine nucleotide transhydrogenase, mitoch	Family
PF02233	PNTB	620 → 1079	NAD(P) transhydrogenase beta subunit	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues. {ECO:0000269|PubMed:22634753}.

Sequence

MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVG
VPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVL
ASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQV
PRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGL
ASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAE
MKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPG
ELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMG
HVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYT
AGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAV
GGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLL
PAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLA
ATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIA
EYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLL
NAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNS
YSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGG
KPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRF
GIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDP
NSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKV
RESYQK

Sequence length

1086

Interactions

View interactions

	KEGG		Reactome
	Nicotinate and nicotinamide metabolism Metabolic pathways		Citric acid cycle (TCA cycle)

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Glucocorticoid Deficiency	Glucocorticoid deficiency 4	rs886039786, rs886039788, rs387907232, rs886039789, rs786205344, rs886039790, rs387907233, rs1579966821, rs786205345, rs370273690, rs387907234, rs864309519	N/A
GLUCOCORTICOID DEFICIENCY WITH MINERALOCORTICOID DEFICIENCY	glucocorticoid deficiency 4 with mineralocorticoid deficiency	rs886039787, rs886039788	N/A

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Barrett esophagus	Barrett's esophagus	N/A	N/A	GWAS
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Addison Disease	Associate	27129361, 34193132, 35627102
Adrenal Insufficiency	Associate	27129361
Alzheimer Disease	Associate	29186589
Bone Diseases Metabolic	Associate	35627102
Breast Neoplasms	Associate	32190687
Carcinoma Renal Cell	Associate	38036719
Cardiomyopathy Hypertrophic	Associate	27129361
Cognition Disorders	Associate	29186589
Congenital Hypothyroidism	Associate	27129361
Cryptorchidism	Associate	27129361
Cystic Fibrosis	Associate	33478087
Diabetes Mellitus	Associate	27459240
Drug Related Side Effects and Adverse Reactions	Inhibit	32187573
Familial Glucocorticoid Deficiency 1	Associate	25459914, 27129361, 35627102
Glioma	Associate	27560795, 31734653
Glucocorticoid Deficiency 2	Associate	23474776, 25459914, 27129361, 27459240
Glucose Intolerance	Associate	23592659
Hearing Loss	Associate	36656851
Heart Failure	Associate	20388492, 27459240
Hypoglycemia	Associate	27129361
Hypothyroidism	Associate	27129361
Hypoxia	Stimulate	27560795
Hypoxia Brain	Associate	27560795
Inflammation	Associate	30823587
Intestinal Pseudo Obstruction	Associate	23592659
Isolated Noncompaction of the Ventricular Myocardium	Associate	27459240
Mineralocorticoid Deficiency Isolated	Associate	27129361
Mitochondrial Diseases	Associate	27459240
Neoplasms	Associate	32187573, 35715447, 37244254
Obesity	Associate	23592659, 27459240
Obesity	Inhibit	30823587
Paraganglioma Extra Adrenal	Associate	27129361
Prostatic Neoplasms	Associate	35715447
Stomach Neoplasms	Associate	37244254
Taste Disorders	Associate	34193132
Triple Negative Breast Neoplasms	Associate	32190687
Uterine Cervical Neoplasms	Associate	18559093

NNT (nicotinamide nucleotide transhydrogenase)