Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23512
Gene name	SUZ12 polycomb repressive complex 2 subunit
Gene symbol	SUZ12
Synonyms (NCBI Gene)	CHET9IMMASJJAZ1
Chromosome	17
Chromosome location	17q11.2
Summary	This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gen

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SNP ID	Visualize variation	Clinical significance	Consequence
rs771704089	C>T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs1131692177	A>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1242271427	G>A	Pathogenic	Splice donor variant
rs1567840381	A>C	Uncertain-significance, pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1567840389	->G	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1598143986	TTAC>-	Pathogenic	5 prime UTR variant, frameshift variant, coding sequence variant, non coding transcript variant, intron variant
rs1598174225	GC>-	Pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant, non coding transcript variant
rs1598192095	T>C	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant

395

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004084	hsa-miR-101-3p	Western blot	19008416
MIRT007118	hsa-miR-19a-3p	Luciferase reporter assay	23451058
MIRT019780	hsa-miR-375	Microarray	20215506
MIRT020638	hsa-miR-155-5p	Proteomics	18668040
MIRT021690	hsa-miR-138-5p	Western blot;qRT-PCR	21770894
MIRT030783	hsa-miR-21-5p	Microarray	18591254
MIRT051542	hsa-let-7e-5p	CLASH	23622248
MIRT047882	hsa-miR-30c-5p	CLASH	23622248
MIRT053349	hsa-miR-128-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	23733246
MIRT053349	hsa-miR-128-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCR	23733246
MIRT053529	hsa-miR-200b-3p	ChIP-seqFlowLuciferase reporter assayWestern blot	23735840
MIRT437850	hsa-miR-487b-3p	ChIP-seqLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23426183
MIRT437850	hsa-miR-487b-3p	ChIP-seqLuciferase reporter assayMicroarrayqRT-PCRWestern blot	23426183
MIRT053529	hsa-miR-200b-3p	Luciferase reporter assay	24169343
MIRT438202	hsa-miR-200c-3p	Luciferase reporter assay	24169343
MIRT053529	hsa-miR-200b-3p	Luciferase reporter assay	24169343
MIRT438202	hsa-miR-200c-3p	Luciferase reporter assay	24169343
MIRT466782	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT466781	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT053349	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT466780	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT076823	hsa-miR-548ac	PAR-CLIP	21572407
MIRT076829	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT076816	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT076817	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT076821	hsa-miR-548z	PAR-CLIP	21572407
MIRT466779	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT466778	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT466777	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT466776	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT466775	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT466774	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT466773	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT076814	hsa-miR-571	PAR-CLIP	21572407
MIRT466772	hsa-miR-423-3p	PAR-CLIP	21572407
MIRT076828	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT242509	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT242505	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT242508	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT242515	hsa-miR-520b	PAR-CLIP	22012620
MIRT242506	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT242507	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT242513	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT242510	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT242516	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT242517	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT242511	hsa-miR-520e	PAR-CLIP	22012620
MIRT242519	hsa-miR-302e	PAR-CLIP	22012620
MIRT534001	hsa-miR-4426	PAR-CLIP	22012620
MIRT534000	hsa-miR-4647	PAR-CLIP	22012620
MIRT533999	hsa-miR-4662b	PAR-CLIP	22012620
MIRT533998	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT533997	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT533996	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT533995	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT533994	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT533993	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT533992	hsa-miR-942-5p	PAR-CLIP	22012620
MIRT242520	hsa-miR-3185	PAR-CLIP	22012620
MIRT533991	hsa-miR-513c-5p	PAR-CLIP	22012620
MIRT533990	hsa-miR-514b-5p	PAR-CLIP	22012620
MIRT466782	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT466781	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT053349	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT466780	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT076823	hsa-miR-548ac	PAR-CLIP	23592263
MIRT076829	hsa-miR-548bb-3p	PAR-CLIP	23592263
MIRT076816	hsa-miR-548d-3p	PAR-CLIP	23592263
MIRT076817	hsa-miR-548h-3p	PAR-CLIP	23592263
MIRT076821	hsa-miR-548z	PAR-CLIP	23592263
MIRT466779	hsa-miR-548ae-3p	PAR-CLIP	23592263
MIRT466778	hsa-miR-548ah-3p	PAR-CLIP	23592263
MIRT466777	hsa-miR-548aj-3p	PAR-CLIP	23592263
MIRT466776	hsa-miR-548am-3p	PAR-CLIP	23592263
MIRT466775	hsa-miR-548aq-3p	PAR-CLIP	23592263
MIRT466774	hsa-miR-548j-3p	PAR-CLIP	23592263
MIRT466773	hsa-miR-548x-3p	PAR-CLIP	23592263
MIRT076814	hsa-miR-571	PAR-CLIP	23592263
MIRT466772	hsa-miR-423-3p	PAR-CLIP	23592263
MIRT076828	hsa-miR-6505-5p	PAR-CLIP	23592263
MIRT007118	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT145511	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT731794	hsa-miR-320a	ImmunofluorescenceLuciferase reporter assayWestern blot	27582550
MIRT731794	hsa-miR-320a	ImmunofluorescenceLuciferase reporter assayWestern blot	27582550
MIRT734847	hsa-miR-200a-3p	RNA-seqqRT-PCRFlow cytometry	33541373
MIRT438205	hsa-miR-200b-3p	RNA-seqqRT-PCRFlow cytometry	33541373
MIRT438202	hsa-miR-200c-3p	RNA-seqqRT-PCRFlow cytometry	33541373
MIRT736043	hsa-miR-362-5p	Western blottingqRT-PCR	31423228
MIRT466782	hsa-miR-3681-3p	PAR-CLIP	21572407
MIRT466781	hsa-miR-216a-3p	PAR-CLIP	21572407
MIRT053349	hsa-miR-128-3p	PAR-CLIP	21572407
MIRT466780	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT076823	hsa-miR-548ac	PAR-CLIP	21572407
MIRT076829	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT076816	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT076817	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT076821	hsa-miR-548z	PAR-CLIP	21572407
MIRT466779	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT466778	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT466777	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT466776	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT466775	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT466774	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT466773	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT076814	hsa-miR-571	PAR-CLIP	21572407
MIRT466772	hsa-miR-423-3p	PAR-CLIP	21572407
MIRT076828	hsa-miR-6505-5p	PAR-CLIP	21572407
MIRT242509	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT242505	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT242508	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT242515	hsa-miR-520b	PAR-CLIP	22012620
MIRT242506	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT242507	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT242513	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT242510	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT242516	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT242517	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT242511	hsa-miR-520e	PAR-CLIP	22012620
MIRT242519	hsa-miR-302e	PAR-CLIP	22012620
MIRT534001	hsa-miR-4426	PAR-CLIP	22012620
MIRT534000	hsa-miR-4647	PAR-CLIP	22012620
MIRT533999	hsa-miR-4662b	PAR-CLIP	22012620
MIRT533998	hsa-miR-141-5p	PAR-CLIP	22012620
MIRT533997	hsa-miR-371b-5p	PAR-CLIP	22012620
MIRT533996	hsa-miR-373-5p	PAR-CLIP	22012620
MIRT533995	hsa-miR-616-5p	PAR-CLIP	22012620
MIRT533994	hsa-miR-371a-5p	PAR-CLIP	22012620
MIRT533993	hsa-miR-372-5p	PAR-CLIP	22012620
MIRT533992	hsa-miR-942-5p	PAR-CLIP	22012620
MIRT242520	hsa-miR-3185	PAR-CLIP	22012620
MIRT533991	hsa-miR-513c-5p	PAR-CLIP	22012620
MIRT533990	hsa-miR-514b-5p	PAR-CLIP	22012620
MIRT466782	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT466781	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT053349	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT466780	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT076823	hsa-miR-548ac	PAR-CLIP	23592263
MIRT076829	hsa-miR-548bb-3p	PAR-CLIP	23592263
MIRT076816	hsa-miR-548d-3p	PAR-CLIP	23592263
MIRT076817	hsa-miR-548h-3p	PAR-CLIP	23592263
MIRT076821	hsa-miR-548z	PAR-CLIP	23592263
MIRT466779	hsa-miR-548ae-3p	PAR-CLIP	23592263
MIRT466778	hsa-miR-548ah-3p	PAR-CLIP	23592263
MIRT466777	hsa-miR-548aj-3p	PAR-CLIP	23592263
MIRT466776	hsa-miR-548am-3p	PAR-CLIP	23592263
MIRT466775	hsa-miR-548aq-3p	PAR-CLIP	23592263
MIRT466774	hsa-miR-548j-3p	PAR-CLIP	23592263
MIRT466773	hsa-miR-548x-3p	PAR-CLIP	23592263
MIRT076814	hsa-miR-571	PAR-CLIP	23592263
MIRT466772	hsa-miR-423-3p	PAR-CLIP	23592263
MIRT076828	hsa-miR-6505-5p	PAR-CLIP	23592263
MIRT1404394	hsa-miR-103a	CLIP-seq
MIRT1404395	hsa-miR-105	CLIP-seq
MIRT1404396	hsa-miR-107	CLIP-seq
MIRT1404397	hsa-miR-1183	CLIP-seq
MIRT1404398	hsa-miR-1248	CLIP-seq
MIRT1404399	hsa-miR-128	CLIP-seq
MIRT1404400	hsa-miR-15a	CLIP-seq
MIRT1404401	hsa-miR-15b	CLIP-seq
MIRT1404402	hsa-miR-16	CLIP-seq
MIRT1404403	hsa-miR-186	CLIP-seq
MIRT1404404	hsa-miR-195	CLIP-seq
MIRT1404405	hsa-miR-19a	CLIP-seq
MIRT1404406	hsa-miR-19b	CLIP-seq
MIRT1404407	hsa-miR-2113	CLIP-seq
MIRT1404408	hsa-miR-27a	CLIP-seq
MIRT1404409	hsa-miR-27b	CLIP-seq
MIRT1404410	hsa-miR-28-3p	CLIP-seq
MIRT1404411	hsa-miR-3120-3p	CLIP-seq
MIRT1404412	hsa-miR-3121-3p	CLIP-seq
MIRT1404413	hsa-miR-3133	CLIP-seq
MIRT1404414	hsa-miR-3146	CLIP-seq
MIRT1404415	hsa-miR-3170	CLIP-seq
MIRT1404416	hsa-miR-340	CLIP-seq
MIRT1404417	hsa-miR-342-5p	CLIP-seq
MIRT1404418	hsa-miR-3614-3p	CLIP-seq
MIRT1404419	hsa-miR-3647-3p	CLIP-seq
MIRT1404420	hsa-miR-3671	CLIP-seq
MIRT1404421	hsa-miR-424	CLIP-seq
MIRT1404422	hsa-miR-4260	CLIP-seq
MIRT1404423	hsa-miR-4310	CLIP-seq
MIRT1404424	hsa-miR-4477b	CLIP-seq
MIRT1404425	hsa-miR-4503	CLIP-seq
MIRT1404426	hsa-miR-4517	CLIP-seq
MIRT1404427	hsa-miR-4651	CLIP-seq
MIRT1404428	hsa-miR-4664-5p	CLIP-seq
MIRT1404429	hsa-miR-4680-3p	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT1404431	hsa-miR-4735-5p	CLIP-seq
MIRT1404432	hsa-miR-4740-3p	CLIP-seq
MIRT1404433	hsa-miR-4742-3p	CLIP-seq
MIRT1404434	hsa-miR-4762-5p	CLIP-seq
MIRT1404435	hsa-miR-4775	CLIP-seq
MIRT1404436	hsa-miR-497	CLIP-seq
MIRT1404437	hsa-miR-501-5p	CLIP-seq
MIRT1404438	hsa-miR-520a-5p	CLIP-seq
MIRT1404439	hsa-miR-525-5p	CLIP-seq
MIRT1404440	hsa-miR-548c-3p	CLIP-seq
MIRT1404441	hsa-miR-548g	CLIP-seq
MIRT1404442	hsa-miR-548u	CLIP-seq
MIRT1404443	hsa-miR-577	CLIP-seq
MIRT1404444	hsa-miR-590-3p	CLIP-seq
MIRT1404445	hsa-miR-607	CLIP-seq
MIRT1404446	hsa-miR-608	CLIP-seq
MIRT1404447	hsa-miR-621	CLIP-seq
MIRT1404448	hsa-miR-640	CLIP-seq
MIRT1404449	hsa-miR-759	CLIP-seq
MIRT1404398	hsa-miR-1248	CLIP-seq
MIRT2121356	hsa-miR-1267	CLIP-seq
MIRT2121357	hsa-miR-1270	CLIP-seq
MIRT1404399	hsa-miR-128	CLIP-seq
MIRT1404405	hsa-miR-19a	CLIP-seq
MIRT1404406	hsa-miR-19b	CLIP-seq
MIRT2121358	hsa-miR-21	CLIP-seq
MIRT1404408	hsa-miR-27a	CLIP-seq
MIRT1404409	hsa-miR-27b	CLIP-seq
MIRT1404412	hsa-miR-3121-3p	CLIP-seq
MIRT2121359	hsa-miR-3124-3p	CLIP-seq
MIRT1404416	hsa-miR-340	CLIP-seq
MIRT2121360	hsa-miR-4282	CLIP-seq
MIRT2121361	hsa-miR-4434	CLIP-seq
MIRT2121362	hsa-miR-4436b-5p	CLIP-seq
MIRT2121363	hsa-miR-4446-5p	CLIP-seq
MIRT2121364	hsa-miR-4516	CLIP-seq
MIRT2121365	hsa-miR-4531	CLIP-seq
MIRT2121366	hsa-miR-4652-3p	CLIP-seq
MIRT2121367	hsa-miR-4668-3p	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT2121368	hsa-miR-4755-5p	CLIP-seq
MIRT1404434	hsa-miR-4762-5p	CLIP-seq
MIRT2121369	hsa-miR-513a-3p	CLIP-seq
MIRT1404440	hsa-miR-548c-3p	CLIP-seq
MIRT1404442	hsa-miR-548u	CLIP-seq
MIRT2121370	hsa-miR-590-5p	CLIP-seq
MIRT2121371	hsa-miR-620	CLIP-seq
MIRT2121372	hsa-miR-642a	CLIP-seq
MIRT2343315	hsa-miR-1179	CLIP-seq
MIRT1404397	hsa-miR-1183	CLIP-seq
MIRT2343316	hsa-miR-1208	CLIP-seq
MIRT2343317	hsa-miR-1243	CLIP-seq
MIRT2343318	hsa-miR-1255a	CLIP-seq
MIRT2343319	hsa-miR-1255b	CLIP-seq
MIRT2343320	hsa-miR-1261	CLIP-seq
MIRT2121357	hsa-miR-1270	CLIP-seq
MIRT1404399	hsa-miR-128	CLIP-seq
MIRT2343321	hsa-miR-1297	CLIP-seq
MIRT2343322	hsa-miR-200b	CLIP-seq
MIRT2343323	hsa-miR-200c	CLIP-seq
MIRT2121358	hsa-miR-21	CLIP-seq
MIRT2343324	hsa-miR-26a	CLIP-seq
MIRT2343325	hsa-miR-26b	CLIP-seq
MIRT2343326	hsa-miR-3065-5p	CLIP-seq
MIRT2121359	hsa-miR-3124-3p	CLIP-seq
MIRT2343327	hsa-miR-3136-5p	CLIP-seq
MIRT2343328	hsa-miR-3201	CLIP-seq
MIRT1404416	hsa-miR-340	CLIP-seq
MIRT2343329	hsa-miR-3654	CLIP-seq
MIRT2343330	hsa-miR-3662	CLIP-seq
MIRT2343331	hsa-miR-3675-3p	CLIP-seq
MIRT2343332	hsa-miR-374c	CLIP-seq
MIRT2343333	hsa-miR-3973	CLIP-seq
MIRT2343334	hsa-miR-429	CLIP-seq
MIRT2343335	hsa-miR-4420	CLIP-seq
MIRT2343336	hsa-miR-4439	CLIP-seq
MIRT2343337	hsa-miR-4465	CLIP-seq
MIRT2343338	hsa-miR-4511	CLIP-seq
MIRT2121365	hsa-miR-4531	CLIP-seq
MIRT2343339	hsa-miR-4698	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT2343340	hsa-miR-4762-3p	CLIP-seq
MIRT2343341	hsa-miR-4791	CLIP-seq
MIRT2343342	hsa-miR-502-5p	CLIP-seq
MIRT2343343	hsa-miR-505	CLIP-seq
MIRT2121369	hsa-miR-513a-3p	CLIP-seq
MIRT2343344	hsa-miR-520g	CLIP-seq
MIRT2343345	hsa-miR-520h	CLIP-seq
MIRT2343346	hsa-miR-548b-3p	CLIP-seq
MIRT1404440	hsa-miR-548c-3p	CLIP-seq
MIRT2343347	hsa-miR-561	CLIP-seq
MIRT2121370	hsa-miR-590-5p	CLIP-seq
MIRT2121371	hsa-miR-620	CLIP-seq
MIRT2343348	hsa-miR-653	CLIP-seq
MIRT2343349	hsa-miR-655	CLIP-seq
MIRT2343350	hsa-miR-664	CLIP-seq
MIRT1404449	hsa-miR-759	CLIP-seq
MIRT2343351	hsa-miR-943	CLIP-seq
MIRT1404399	hsa-miR-128	CLIP-seq
MIRT1404408	hsa-miR-27a	CLIP-seq
MIRT1404409	hsa-miR-27b	CLIP-seq
MIRT2433747	hsa-miR-455-5p	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT1404434	hsa-miR-4762-5p	CLIP-seq
MIRT2433748	hsa-miR-4766-3p	CLIP-seq
MIRT2433749	hsa-miR-548p	CLIP-seq
MIRT1404442	hsa-miR-548u	CLIP-seq
MIRT1404395	hsa-miR-105	CLIP-seq
MIRT2637030	hsa-miR-132	CLIP-seq
MIRT2637031	hsa-miR-203	CLIP-seq
MIRT2637032	hsa-miR-212	CLIP-seq
MIRT2637033	hsa-miR-216a	CLIP-seq
MIRT2637034	hsa-miR-2355-3p	CLIP-seq
MIRT2343326	hsa-miR-3065-5p	CLIP-seq
MIRT2121359	hsa-miR-3124-3p	CLIP-seq
MIRT2637035	hsa-miR-3125	CLIP-seq
MIRT2637036	hsa-miR-3189-3p	CLIP-seq
MIRT2637037	hsa-miR-3605-5p	CLIP-seq
MIRT1404419	hsa-miR-3647-3p	CLIP-seq
MIRT2343330	hsa-miR-3662	CLIP-seq
MIRT2637038	hsa-miR-3682-5p	CLIP-seq
MIRT2637039	hsa-miR-371-5p	CLIP-seq
MIRT2637040	hsa-miR-380	CLIP-seq
MIRT2637041	hsa-miR-3913-3p	CLIP-seq
MIRT2637042	hsa-miR-3916	CLIP-seq
MIRT2637043	hsa-miR-3938	CLIP-seq
MIRT2637044	hsa-miR-421	CLIP-seq
MIRT2637045	hsa-miR-4276	CLIP-seq
MIRT2121360	hsa-miR-4282	CLIP-seq
MIRT2637046	hsa-miR-4302	CLIP-seq
MIRT2637047	hsa-miR-4452	CLIP-seq
MIRT2637048	hsa-miR-450b-5p	CLIP-seq
MIRT2637049	hsa-miR-4646-3p	CLIP-seq
MIRT2121367	hsa-miR-4668-3p	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT2637050	hsa-miR-4709-5p	CLIP-seq
MIRT2637051	hsa-miR-4729	CLIP-seq
MIRT1404431	hsa-miR-4735-5p	CLIP-seq
MIRT1404435	hsa-miR-4775	CLIP-seq
MIRT2637052	hsa-miR-4803	CLIP-seq
MIRT2637053	hsa-miR-489	CLIP-seq
MIRT2637054	hsa-miR-500b	CLIP-seq
MIRT1404437	hsa-miR-501-5p	CLIP-seq
MIRT2343342	hsa-miR-502-5p	CLIP-seq
MIRT2343343	hsa-miR-505	CLIP-seq
MIRT2637055	hsa-miR-513c	CLIP-seq
MIRT2637056	hsa-miR-515-3p	CLIP-seq
MIRT2637057	hsa-miR-519e	CLIP-seq
MIRT2637058	hsa-miR-548ae	CLIP-seq
MIRT2637059	hsa-miR-548aj	CLIP-seq
MIRT2637060	hsa-miR-548am	CLIP-seq
MIRT2637061	hsa-miR-548x	CLIP-seq
MIRT2637062	hsa-miR-550a	CLIP-seq
MIRT2637063	hsa-miR-556-3p	CLIP-seq
MIRT2343347	hsa-miR-561	CLIP-seq
MIRT1404444	hsa-miR-590-3p	CLIP-seq
MIRT2343348	hsa-miR-653	CLIP-seq
MIRT2637064	hsa-miR-877	CLIP-seq
MIRT2637065	hsa-miR-888	CLIP-seq
MIRT2637066	hsa-miR-889	CLIP-seq
MIRT2637067	hsa-miR-942	CLIP-seq
MIRT1404395	hsa-miR-105	CLIP-seq
MIRT2637030	hsa-miR-132	CLIP-seq
MIRT2637031	hsa-miR-203	CLIP-seq
MIRT2637032	hsa-miR-212	CLIP-seq
MIRT2637033	hsa-miR-216a	CLIP-seq
MIRT2692450	hsa-miR-302a	CLIP-seq
MIRT2692451	hsa-miR-302b	CLIP-seq
MIRT2692452	hsa-miR-302c	CLIP-seq
MIRT2692453	hsa-miR-302d	CLIP-seq
MIRT2343326	hsa-miR-3065-5p	CLIP-seq
MIRT2121359	hsa-miR-3124-3p	CLIP-seq
MIRT2637036	hsa-miR-3189-3p	CLIP-seq
MIRT2692454	hsa-miR-3617	CLIP-seq
MIRT1404419	hsa-miR-3647-3p	CLIP-seq
MIRT2637038	hsa-miR-3682-5p	CLIP-seq
MIRT2637039	hsa-miR-371-5p	CLIP-seq
MIRT2692455	hsa-miR-372	CLIP-seq
MIRT2692456	hsa-miR-373	CLIP-seq
MIRT2637041	hsa-miR-3913-3p	CLIP-seq
MIRT2121360	hsa-miR-4282	CLIP-seq
MIRT2637048	hsa-miR-450b-5p	CLIP-seq
MIRT2121367	hsa-miR-4668-3p	CLIP-seq
MIRT1404430	hsa-miR-4699-3p	CLIP-seq
MIRT2637051	hsa-miR-4729	CLIP-seq
MIRT1404431	hsa-miR-4735-5p	CLIP-seq
MIRT1404435	hsa-miR-4775	CLIP-seq
MIRT2637053	hsa-miR-489	CLIP-seq
MIRT2637054	hsa-miR-500b	CLIP-seq
MIRT1404437	hsa-miR-501-5p	CLIP-seq
MIRT2343342	hsa-miR-502-5p	CLIP-seq
MIRT2343343	hsa-miR-505	CLIP-seq
MIRT2637055	hsa-miR-513c	CLIP-seq
MIRT2637056	hsa-miR-515-3p	CLIP-seq
MIRT2692457	hsa-miR-518a-5p	CLIP-seq
MIRT2637057	hsa-miR-519e	CLIP-seq
MIRT2692458	hsa-miR-527	CLIP-seq
MIRT2637058	hsa-miR-548ae	CLIP-seq
MIRT2637059	hsa-miR-548aj	CLIP-seq
MIRT2637060	hsa-miR-548am	CLIP-seq
MIRT2637061	hsa-miR-548x	CLIP-seq
MIRT2637062	hsa-miR-550a	CLIP-seq
MIRT1404444	hsa-miR-590-3p	CLIP-seq
MIRT2692459	hsa-miR-641	CLIP-seq
MIRT2343348	hsa-miR-653	CLIP-seq
MIRT2637066	hsa-miR-889	CLIP-seq
MIRT2637067	hsa-miR-942	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0001222	Function	Transcription corepressor binding	IPI	29628311
GO:0001739	Component	Sex chromatin	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17560333, 19734898, 20075857, 20543829, 21078963, 22009739, 22439931, 23104054, 23238014, 23684459, 24183680, 24981860, 26496610, 27705803, 27728805, 28229514, 29628311, 29909548, 30026490, 30923826, 33961781, 34591612, 35016035, 37553330
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005677	Component	Chromatin silencing complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0008047	Function	Enzyme activator activity	IMP	15385962, 28229514
GO:0008270	Function	Zinc ion binding	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0016586	Component	RSC-type complex	IBA
GO:0016604	Component	Nuclear body	IDA
GO:0031490	Function	Chromatin DNA binding	IBA
GO:0031490	Function	Chromatin DNA binding	IEA
GO:0032993	Component	Protein-DNA complex	IEA
GO:0035098	Component	ESC/E(Z) complex	IBA
GO:0035098	Component	ESC/E(Z) complex	IDA	20075857, 23104054, 23273982
GO:0035098	Component	ESC/E(Z) complex	IEA
GO:0035098	Component	ESC/E(Z) complex	IMP	15385962
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045596	Process	Negative regulation of cell differentiation	IMP	19847889
GO:0046872	Function	Metal ion binding	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0060816	Process	Random inactivation of X chromosome	IEA
GO:0062072	Function	Histone H3K9me2/3 reader activity	IDA	21029866
GO:0106222	Function	LncRNA binding	IEA
GO:0140718	Process	Facultative heterochromatin formation	IEA
GO:1990841	Function	Promoter-specific chromatin binding	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
606245	17101	ENSG00000178691

Q15022

Protein name

Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)

Protein function

Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:1538

PDB

4W2R , 5HYN , 5IJ7 , 5IJ8 , 5LS6 , 5WAI , 5WAK , 5WG6 , 6B3W , 6C23 , 6C24 , 6NQ3 , 6WKR , 7AT8 , 7KSO , 7KSR , 7KTP , 7TD5 , 8EQV , 8FYH , 8T9G , 8TAS , 8TB9 , 8VMI , 8VML , 8VNV , 8VNZ , 9C8U , 9DCH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09733	VEFS-Box	546 → 680	VEFS-Box of polycomb protein	Family

Tissue specificity

TISSUE SPECIFICITY: Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}.

Sequence

MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSA
AAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSH
RNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQN
SVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPS
NSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMT
VFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLR
WTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPN
ENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVY
HPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASM
SEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQI
EEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHL
VSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEK
ALETDSVSGVSKQSKKQKL

Sequence length

739

Interactions

View interactions

	KEGG		Reactome
	Polycomb repressive complex		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Acute megakaryoblastic leukemia in down syndrome	Likely pathogenic; Pathogenic	rs1909527513	RCV001293761
Imagawa-Matsumoto syndrome	Likely pathogenic; Pathogenic	rs2142215876, rs2142222219, rs2142215091, rs2142222377, rs2142117453, rs2508662320, rs2508677290, rs2508661900, rs2508684640, rs1131692177, rs1598143986, rs1598174225, rs1598192095, rs771704089, rs1909936773, rs750383066 View all (1 more)	RCV001375951 RCV005635141 RCV001808266 RCV002249186 RCV002246753 RCV002284008 RCV003151930 RCV003234950 RCV004555524 RCV000495116 RCV004803212 RCV001003509 RCV001003510 RCV001003511 RCV001254135 RCV005630905
Non-immune hydrops fetalis	Likely pathogenic	rs2142215876	RCV002285026
SUZ12-related disorder	Likely pathogenic; Pathogenic	rs372162318	RCV003419132

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Developmental disorder	Uncertain significance	rs2142178714	RCV001843713
IDH-wildtype glioblastoma	Uncertain significance	rs2508679655	RCV006254366
Neurodevelopmental disorder	Uncertain significance	rs1910003061	RCV002272915
Teratoma	Uncertain significance	rs2508693811	RCV003221384
Weaver syndrome	Uncertain significance	rs1567840381	RCV000722110

Show/Hide Text Mining Associations (74)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenosarcoma	Associate	33838572
Anemia Aplastic	Associate	33166403
Brain Neoplasms	Associate	20920292
Breast Neoplasms	Associate	16766534, 24434785
Carcinogenesis	Associate	23735840, 34667274, 35649353
Carcinoma Hepatocellular	Associate	18753137
Carcinoma Merkel Cell	Associate	34667274
Carcinoma Non Small Cell Lung	Associate	24633887, 25833694
Cardiomyopathies	Associate	32620106
Cholangiocarcinoma	Associate	24089088
Colonic Neoplasms	Stimulate	11564866
Colorectal Neoplasms	Associate	15231737, 23001792, 25243792, 26567139, 30791232
Craniosynostoses	Associate	36982425
Depressive Disorder	Associate	28418861
Endometrial Stromal Tumors	Associate	11371647, 18077430, 35649353, 36731460
Esophageal Squamous Cell Carcinoma	Associate	32699215
GATA2 Deficiency	Associate	26337274
Heart Failure	Associate	32620106
Hemoglobinuria Paroxysmal	Associate	25244093
Huntington Disease	Associate	26636336, 33054835
Hypoxia	Stimulate	27303043
Hypoxia	Inhibit	37967992
Infratentorial Neoplasms	Associate	29909548
Iridogoniodysgenesis and skeletal anomalies	Associate	30019515
Leukemia	Associate	17560333, 22190018
Leukemia Large Granular Lymphocytic	Associate	37142644
Leukemia Lymphocytic Chronic B Cell	Associate	30038380
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26017281, 34784413
Leukemia Myeloid	Associate	22053108
Leukemia Myeloid Acute	Associate	22371884, 33166403, 35747989
Leukemia Myeloid Chronic Phase	Associate	26017281
Leukemia Neutrophilic Chronic	Associate	33166403
Lung Diseases	Associate	19536353
Lung Neoplasms	Associate	20558579
Lymphatic Metastasis	Stimulate	24633887
Lymphoma Follicular	Associate	19530241
Lymphoma Mantle Cell	Associate	20558579
Malignant mesenchymal tumor	Associate	32889887, 33986460
MASS syndrome	Associate	31615558
Melanoma	Associate	20558579
Michelin tire baby syndrome	Associate	30019515
Mitochondrial Diseases	Associate	30404791
Myelodysplastic Syndromes	Associate	22053108, 33166403
Myeloproliferative Disorders	Associate	26290261
Myocardial Infarction	Stimulate	37967992
Neoplasm Metastasis	Stimulate	24633887
Neoplasms	Associate	18077430, 18753137, 20558579, 22053108, 22190018, 23101500, 24633887, 25244093, 26429873, 26837964, 29482987, 31615558, 32317704, 32666581, 32889887 View all (6 more)
Neuroblastoma	Associate	29202477
Neurofibroma	Associate	37145209
Neurofibroma Plexiform	Stimulate	20844836
Neurofibromatosis 1	Associate	38008284
Neurofibrosarcoma	Associate	25240281, 25305755, 26585554, 26645727, 26990975, 28752843, 28762137, 29482987, 30291346, 32666581, 35852856, 37246765
Neutropenia Severe Congenital Autosomal Recessive 3	Associate	33166403
Obesity	Associate	32555314
Perivascular Epithelioid Cell Neoplasms	Associate	34561551
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22237106, 30404791
Primary Myelofibrosis	Associate	22053108
Prostatic Neoplasms	Associate	15817459
Renal Insufficiency	Associate	33960101
Rhabdomyosarcoma	Associate	30120321
Sarcoma	Associate	18077430, 29415665, 34561551
Sarcoma Endometrial Stromal	Associate	22982899, 26429873, 31615558, 33838572, 34561551, 34928964, 35649353, 35710139, 36731460, 37406360
Simpson Golabi Behmel syndrome	Associate	30019515
Squamous Cell Carcinoma of Head and Neck	Associate	24076275, 31938073
Stomach Diseases	Associate	23735840
Stomach Neoplasms	Associate	23735840, 26837964
Triple Negative Breast Neoplasms	Associate	30295334
Uniparental Disomy	Associate	22053108
Urinary Bladder Neoplasms	Associate	18984978
Uterine Cervical Neoplasms	Associate	18753137
Uterine Neoplasms	Associate	31615558
Weaver Like Syndrome	Associate	30019515
Weaver syndrome	Associate	30019515
Wounds and Injuries	Inhibit	37967992

SUZ12 (SUZ12 polycomb repressive complex 2 subunit)