Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23504
Gene name Gene Name - the full gene name approved by the HGNC.	RIMS binding protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RIMBP2
Synonyms (NCBI Gene) Gene synonyms aliases	PPP1R133, RBP2, RIM-BP2
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.33

Show/Hide all(131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724868	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT724867	hsa-miR-4286	HITS-CLIP	19536157
MIRT724866	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT724865	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT724864	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT724863	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT724862	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT724861	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT724860	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT724868	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT724867	hsa-miR-4286	HITS-CLIP	19536157
MIRT724866	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT724865	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT724864	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT724863	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT724862	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT724861	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT724860	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT1306737	hsa-miR-106a	CLIP-seq
MIRT1306738	hsa-miR-106b	CLIP-seq
MIRT1306739	hsa-miR-1224-5p	CLIP-seq
MIRT1306740	hsa-miR-1304	CLIP-seq
MIRT1306741	hsa-miR-1343	CLIP-seq
MIRT1306742	hsa-miR-17	CLIP-seq
MIRT1306743	hsa-miR-2053	CLIP-seq
MIRT1306744	hsa-miR-20a	CLIP-seq
MIRT1306745	hsa-miR-20b	CLIP-seq
MIRT1306746	hsa-miR-2110	CLIP-seq
MIRT1306747	hsa-miR-218	CLIP-seq
MIRT1306748	hsa-miR-219-5p	CLIP-seq
MIRT1306749	hsa-miR-2682	CLIP-seq
MIRT1306750	hsa-miR-3064-3p	CLIP-seq
MIRT1306751	hsa-miR-3140-3p	CLIP-seq
MIRT1306752	hsa-miR-3150b-3p	CLIP-seq
MIRT1306753	hsa-miR-3609	CLIP-seq
MIRT1306754	hsa-miR-3714	CLIP-seq
MIRT1306755	hsa-miR-374a	CLIP-seq
MIRT1306756	hsa-miR-374b	CLIP-seq
MIRT1306757	hsa-miR-3907	CLIP-seq
MIRT1306758	hsa-miR-3915	CLIP-seq
MIRT1306759	hsa-miR-4271	CLIP-seq
MIRT1306760	hsa-miR-4445	CLIP-seq
MIRT1306761	hsa-miR-4477a	CLIP-seq
MIRT1306762	hsa-miR-4484	CLIP-seq
MIRT1306763	hsa-miR-449c	CLIP-seq
MIRT1306764	hsa-miR-4689	CLIP-seq
MIRT1306765	hsa-miR-4709-3p	CLIP-seq
MIRT1306766	hsa-miR-4725-3p	CLIP-seq
MIRT1306767	hsa-miR-4766-5p	CLIP-seq
MIRT1306768	hsa-miR-4773	CLIP-seq
MIRT1306769	hsa-miR-4782-3p	CLIP-seq
MIRT1306770	hsa-miR-4784	CLIP-seq
MIRT1306771	hsa-miR-4796-3p	CLIP-seq
MIRT1306772	hsa-miR-508-3p	CLIP-seq
MIRT1306773	hsa-miR-519a	CLIP-seq
MIRT1306774	hsa-miR-519b-3p	CLIP-seq
MIRT1306775	hsa-miR-519c-3p	CLIP-seq
MIRT1306776	hsa-miR-519d	CLIP-seq
MIRT1306777	hsa-miR-520d-5p	CLIP-seq
MIRT1306778	hsa-miR-524-5p	CLIP-seq
MIRT1306779	hsa-miR-548ah	CLIP-seq
MIRT1306780	hsa-miR-548an	CLIP-seq
MIRT1306781	hsa-miR-622	CLIP-seq
MIRT1306782	hsa-miR-636	CLIP-seq
MIRT1306783	hsa-miR-765	CLIP-seq
MIRT1306784	hsa-miR-93	CLIP-seq
MIRT1306737	hsa-miR-106a	CLIP-seq
MIRT1306738	hsa-miR-106b	CLIP-seq
MIRT1306742	hsa-miR-17	CLIP-seq
MIRT1306744	hsa-miR-20a	CLIP-seq
MIRT1306745	hsa-miR-20b	CLIP-seq
MIRT2090915	hsa-miR-3176	CLIP-seq
MIRT2090916	hsa-miR-3922-3p	CLIP-seq
MIRT2090917	hsa-miR-4463	CLIP-seq
MIRT2090918	hsa-miR-4676-5p	CLIP-seq
MIRT2090919	hsa-miR-4701-5p	CLIP-seq
MIRT2090920	hsa-miR-4768-5p	CLIP-seq
MIRT2090921	hsa-miR-5095	CLIP-seq
MIRT1306773	hsa-miR-519a	CLIP-seq
MIRT1306774	hsa-miR-519b-3p	CLIP-seq
MIRT1306775	hsa-miR-519c-3p	CLIP-seq
MIRT1306776	hsa-miR-519d	CLIP-seq
MIRT2090922	hsa-miR-548u	CLIP-seq
MIRT2090923	hsa-miR-552	CLIP-seq
MIRT2090924	hsa-miR-575	CLIP-seq
MIRT2090925	hsa-miR-588	CLIP-seq
MIRT1306784	hsa-miR-93	CLIP-seq
MIRT2315559	hsa-miR-103a	CLIP-seq
MIRT2315560	hsa-miR-107	CLIP-seq
MIRT2315561	hsa-miR-1179	CLIP-seq
MIRT2315562	hsa-miR-148a	CLIP-seq
MIRT2315563	hsa-miR-148b	CLIP-seq
MIRT2315564	hsa-miR-152	CLIP-seq
MIRT2315565	hsa-miR-15a	CLIP-seq
MIRT2315566	hsa-miR-15b	CLIP-seq
MIRT2315567	hsa-miR-16	CLIP-seq
MIRT2315568	hsa-miR-195	CLIP-seq
MIRT1306743	hsa-miR-2053	CLIP-seq
MIRT2315569	hsa-miR-3064-5p	CLIP-seq
MIRT2315570	hsa-miR-3119	CLIP-seq
MIRT2315571	hsa-miR-34a	CLIP-seq
MIRT2315572	hsa-miR-34c-5p	CLIP-seq
MIRT2315573	hsa-miR-3652	CLIP-seq
MIRT2315574	hsa-miR-3653	CLIP-seq
MIRT2315575	hsa-miR-3658	CLIP-seq
MIRT2315576	hsa-miR-3944-5p	CLIP-seq
MIRT2315577	hsa-miR-424	CLIP-seq
MIRT2315578	hsa-miR-4293	CLIP-seq
MIRT2315579	hsa-miR-4310	CLIP-seq
MIRT2315580	hsa-miR-4430	CLIP-seq
MIRT2315581	hsa-miR-4453	CLIP-seq
MIRT2090917	hsa-miR-4463	CLIP-seq
MIRT2315582	hsa-miR-449a	CLIP-seq
MIRT2315583	hsa-miR-449b	CLIP-seq
MIRT2315584	hsa-miR-4505	CLIP-seq
MIRT2315585	hsa-miR-4538	CLIP-seq
MIRT2315586	hsa-miR-488	CLIP-seq
MIRT2315587	hsa-miR-497	CLIP-seq
MIRT2090921	hsa-miR-5095	CLIP-seq
MIRT2090922	hsa-miR-548u	CLIP-seq
MIRT2090923	hsa-miR-552	CLIP-seq
MIRT2315588	hsa-miR-596	CLIP-seq
MIRT2090915	hsa-miR-3176	CLIP-seq
MIRT2090916	hsa-miR-3922-3p	CLIP-seq
MIRT2442561	hsa-miR-214	CLIP-seq
MIRT2442562	hsa-miR-3619-5p	CLIP-seq
MIRT2442563	hsa-miR-4291	CLIP-seq
MIRT2442564	hsa-miR-578	CLIP-seq
MIRT2442565	hsa-miR-761	CLIP-seq
MIRT2442566	hsa-miR-922	CLIP-seq
MIRT2458236	hsa-miR-3978	CLIP-seq

Show/Hide all(4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IEA
GO:0007274	Process	Neuromuscular synaptic transmission	IBA	21873635
GO:0010923	Process	Negative regulation of phosphatase activity	IDA	19389623
GO:0045202	Component	Synapse	IEA

MIM	HGNC	e!Ensembl
611602	30339	ENSG00000060709

Protein

UniProt ID

O15034

Protein name

RIMS-binding protein 2 (RIM-BP2)

Protein function

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.

PDB

1WIE , 2CSI , 2CSP , 2CSQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	174 → 230	Variant SH3 domain	Domain
PF07653	SH3_2	852 → 914	Variant SH3 domain	Domain
PF14604	SH3_9	959 → 1015	Variant SH3 domain	Domain

Sequence

MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKSKVRELEEKCRTQSEQFNLLSRDLEK
FRQHAGKIDLLGGSAVAPLDISTAPSKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRP
LPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNP
FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLA
STLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYP
RKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMA
ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSH
VIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFS
TLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVI
FPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSK
PLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQ
GTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGA
SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSG
TSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEESE
TDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC
ARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVAL
YDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDD
VEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP

Sequence length

1052

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Hirschsprung disease	Hirschsprung Disease	rs76262710, rs75996173, rs77316810, rs75076352, rs76534745, rs76764689, rs76449634, rs377767412, rs193922699, rs75030001, rs606231342, rs1553540620, rs759944122, rs1057519322, rs1057519323 View all (4 more)	19196962
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Dementia	Dementia		GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Asthma	Associate	37466093
Carcinoma Hepatocellular	Associate	35473892
Carcinoma Squamous Cell	Associate	32036209
Pulmonary Disease Chronic Obstructive	Associate	37466093

RIMBP2 (RIMS binding protein 2)