RIMBP2 (RIMS binding protein 2)

Gene

• Entrez ID: 23504
• Gene name: RIMS binding protein 2
• Gene symbol: RIMBP2
• Synonyms (NCBI Gene): PPP1R133, RBP2, RIM-BP2
• Chromosome: 12
• Chromosome location: 12q24.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT724868	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT724867	hsa-miR-4286	HITS-CLIP	19536157
MIRT724866	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT724865	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT724864	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT724863	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT724862	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT724861	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT724860	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT724868	hsa-miR-330-3p	HITS-CLIP	19536157
MIRT724867	hsa-miR-4286	HITS-CLIP	19536157
MIRT724866	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT724865	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT724864	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT724863	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT724862	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT724861	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT724860	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT1306737	hsa-miR-106a	CLIP-seq
MIRT1306738	hsa-miR-106b	CLIP-seq
MIRT1306739	hsa-miR-1224-5p	CLIP-seq
MIRT1306740	hsa-miR-1304	CLIP-seq
MIRT1306741	hsa-miR-1343	CLIP-seq
MIRT1306742	hsa-miR-17	CLIP-seq
MIRT1306743	hsa-miR-2053	CLIP-seq
MIRT1306744	hsa-miR-20a	CLIP-seq
MIRT1306745	hsa-miR-20b	CLIP-seq
MIRT1306746	hsa-miR-2110	CLIP-seq
MIRT1306747	hsa-miR-218	CLIP-seq
MIRT1306748	hsa-miR-219-5p	CLIP-seq
MIRT1306749	hsa-miR-2682	CLIP-seq
MIRT1306750	hsa-miR-3064-3p	CLIP-seq
MIRT1306751	hsa-miR-3140-3p	CLIP-seq
MIRT1306752	hsa-miR-3150b-3p	CLIP-seq
MIRT1306753	hsa-miR-3609	CLIP-seq
MIRT1306754	hsa-miR-3714	CLIP-seq
MIRT1306755	hsa-miR-374a	CLIP-seq
MIRT1306756	hsa-miR-374b	CLIP-seq
MIRT1306757	hsa-miR-3907	CLIP-seq
MIRT1306758	hsa-miR-3915	CLIP-seq
MIRT1306759	hsa-miR-4271	CLIP-seq
MIRT1306760	hsa-miR-4445	CLIP-seq
MIRT1306761	hsa-miR-4477a	CLIP-seq
MIRT1306762	hsa-miR-4484	CLIP-seq
MIRT1306763	hsa-miR-449c	CLIP-seq
MIRT1306764	hsa-miR-4689	CLIP-seq
MIRT1306765	hsa-miR-4709-3p	CLIP-seq
MIRT1306766	hsa-miR-4725-3p	CLIP-seq
MIRT1306767	hsa-miR-4766-5p	CLIP-seq
MIRT1306768	hsa-miR-4773	CLIP-seq
MIRT1306769	hsa-miR-4782-3p	CLIP-seq
MIRT1306770	hsa-miR-4784	CLIP-seq
MIRT1306771	hsa-miR-4796-3p	CLIP-seq
MIRT1306772	hsa-miR-508-3p	CLIP-seq
MIRT1306773	hsa-miR-519a	CLIP-seq
MIRT1306774	hsa-miR-519b-3p	CLIP-seq
MIRT1306775	hsa-miR-519c-3p	CLIP-seq
MIRT1306776	hsa-miR-519d	CLIP-seq
MIRT1306777	hsa-miR-520d-5p	CLIP-seq
MIRT1306778	hsa-miR-524-5p	CLIP-seq
MIRT1306779	hsa-miR-548ah	CLIP-seq
MIRT1306780	hsa-miR-548an	CLIP-seq
MIRT1306781	hsa-miR-622	CLIP-seq
MIRT1306782	hsa-miR-636	CLIP-seq
MIRT1306783	hsa-miR-765	CLIP-seq
MIRT1306784	hsa-miR-93	CLIP-seq
MIRT1306737	hsa-miR-106a	CLIP-seq
MIRT1306738	hsa-miR-106b	CLIP-seq
MIRT1306742	hsa-miR-17	CLIP-seq
MIRT1306744	hsa-miR-20a	CLIP-seq
MIRT1306745	hsa-miR-20b	CLIP-seq
MIRT2090915	hsa-miR-3176	CLIP-seq
MIRT2090916	hsa-miR-3922-3p	CLIP-seq
MIRT2090917	hsa-miR-4463	CLIP-seq
MIRT2090918	hsa-miR-4676-5p	CLIP-seq
MIRT2090919	hsa-miR-4701-5p	CLIP-seq
MIRT2090920	hsa-miR-4768-5p	CLIP-seq
MIRT2090921	hsa-miR-5095	CLIP-seq
MIRT1306773	hsa-miR-519a	CLIP-seq
MIRT1306774	hsa-miR-519b-3p	CLIP-seq
MIRT1306775	hsa-miR-519c-3p	CLIP-seq
MIRT1306776	hsa-miR-519d	CLIP-seq
MIRT2090922	hsa-miR-548u	CLIP-seq
MIRT2090923	hsa-miR-552	CLIP-seq
MIRT2090924	hsa-miR-575	CLIP-seq
MIRT2090925	hsa-miR-588	CLIP-seq
MIRT1306784	hsa-miR-93	CLIP-seq
MIRT2315559	hsa-miR-103a	CLIP-seq
MIRT2315560	hsa-miR-107	CLIP-seq
MIRT2315561	hsa-miR-1179	CLIP-seq
MIRT2315562	hsa-miR-148a	CLIP-seq
MIRT2315563	hsa-miR-148b	CLIP-seq
MIRT2315564	hsa-miR-152	CLIP-seq
MIRT2315565	hsa-miR-15a	CLIP-seq
MIRT2315566	hsa-miR-15b	CLIP-seq
MIRT2315567	hsa-miR-16	CLIP-seq
MIRT2315568	hsa-miR-195	CLIP-seq
MIRT1306743	hsa-miR-2053	CLIP-seq
MIRT2315569	hsa-miR-3064-5p	CLIP-seq
MIRT2315570	hsa-miR-3119	CLIP-seq
MIRT2315571	hsa-miR-34a	CLIP-seq
MIRT2315572	hsa-miR-34c-5p	CLIP-seq
MIRT2315573	hsa-miR-3652	CLIP-seq
MIRT2315574	hsa-miR-3653	CLIP-seq
MIRT2315575	hsa-miR-3658	CLIP-seq
MIRT2315576	hsa-miR-3944-5p	CLIP-seq
MIRT2315577	hsa-miR-424	CLIP-seq
MIRT2315578	hsa-miR-4293	CLIP-seq
MIRT2315579	hsa-miR-4310	CLIP-seq
MIRT2315580	hsa-miR-4430	CLIP-seq
MIRT2315581	hsa-miR-4453	CLIP-seq
MIRT2090917	hsa-miR-4463	CLIP-seq
MIRT2315582	hsa-miR-449a	CLIP-seq
MIRT2315583	hsa-miR-449b	CLIP-seq
MIRT2315584	hsa-miR-4505	CLIP-seq
MIRT2315585	hsa-miR-4538	CLIP-seq
MIRT2315586	hsa-miR-488	CLIP-seq
MIRT2315587	hsa-miR-497	CLIP-seq
MIRT2090921	hsa-miR-5095	CLIP-seq
MIRT2090922	hsa-miR-548u	CLIP-seq
MIRT2090923	hsa-miR-552	CLIP-seq
MIRT2315588	hsa-miR-596	CLIP-seq
MIRT2090915	hsa-miR-3176	CLIP-seq
MIRT2090916	hsa-miR-3922-3p	CLIP-seq
MIRT2442561	hsa-miR-214	CLIP-seq
MIRT2442562	hsa-miR-3619-5p	CLIP-seq
MIRT2442563	hsa-miR-4291	CLIP-seq
MIRT2442564	hsa-miR-578	CLIP-seq
MIRT2442565	hsa-miR-761	CLIP-seq
MIRT2442566	hsa-miR-922	CLIP-seq
MIRT2458236	hsa-miR-3978	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0007274	Process	Neuromuscular synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA

Other IDs

• MIM: 611602
• HGNC: 30339
• e!Ensembl: ENSG00000060709

Protein

• UniProt ID: O15034
• Protein name: RIMS-binding protein 2 (RIM-BP2)
• Protein function: Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
• PDB: 1WIE, 2CSI, 2CSP, 2CSQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14604	SH3_9	174 → 230	Variant SH3 domain	Domain
  PF07653	SH3_2	852 → 914	Variant SH3 domain	Domain
  PF14604	SH3_9	959 → 1015	Variant SH3 domain	Domain

• Sequence:

  MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKSKVRELEEKCRTQSEQFNLLSRDLEK
  FRQHAGKIDLLGGSAVAPLDISTAPSKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRP
  LPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNP
  FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLA
  STLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYP
  RKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMA
  ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSH
  VIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFS
  TLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVI
  FPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSK
  PLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQ
  GTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGA
  SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSG
  TSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEESE
  TDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC
  ARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVAL
  YDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDD
  VEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP

• Sequence length: 1052