CES3 (carboxylesterase 3)

Gene

• Entrez ID: 23491
• Gene name: Carboxylesterase 3
• Gene symbol: CES3
• Synonyms (NCBI Gene): ES31
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bon

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030333	hsa-miR-26b-5p	Microarray	19088304
MIRT451751	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT451750	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT451749	hsa-miR-4257	PAR-CLIP	23592263
MIRT451748	hsa-miR-6134	PAR-CLIP	23592263
MIRT451747	hsa-miR-5699-5p	PAR-CLIP	23592263
MIRT451746	hsa-miR-4758-3p	PAR-CLIP	23592263
MIRT451745	hsa-miR-3189-5p	PAR-CLIP	23592263
MIRT451744	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451743	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451742	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451740	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451741	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451739	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT451738	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT451737	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT451736	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT451735	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT451734	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT451733	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT451732	hsa-miR-3689c	PAR-CLIP	23592263
MIRT451731	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT451730	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT451729	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT451728	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT451727	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT451726	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT451751	hsa-miR-365a-3p	PAR-CLIP	23592263
MIRT451750	hsa-miR-365b-3p	PAR-CLIP	23592263
MIRT451749	hsa-miR-4257	PAR-CLIP	23592263
MIRT451748	hsa-miR-6134	PAR-CLIP	23592263
MIRT451747	hsa-miR-5699-5p	PAR-CLIP	23592263
MIRT451746	hsa-miR-4758-3p	PAR-CLIP	23592263
MIRT451745	hsa-miR-3189-5p	PAR-CLIP	23592263
MIRT451744	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT451743	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT451742	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT451740	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT451741	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT451739	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT451738	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT451737	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT451736	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT451735	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT451734	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT451733	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT451732	hsa-miR-3689c	PAR-CLIP	23592263
MIRT451731	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT451730	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT451729	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT451728	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT451727	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT451726	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT887213	hsa-miR-188-5p	CLIP-seq
MIRT887214	hsa-miR-4305	CLIP-seq
MIRT887215	hsa-miR-4699-3p	CLIP-seq
MIRT887216	hsa-miR-1205	CLIP-seq
MIRT887217	hsa-miR-1233	CLIP-seq
MIRT887218	hsa-miR-1254	CLIP-seq
MIRT887219	hsa-miR-1270	CLIP-seq
MIRT887220	hsa-miR-138	CLIP-seq
MIRT887221	hsa-miR-141	CLIP-seq
MIRT887222	hsa-miR-1827	CLIP-seq
MIRT887213	hsa-miR-188-5p	CLIP-seq
MIRT887223	hsa-miR-1913	CLIP-seq
MIRT887224	hsa-miR-200a	CLIP-seq
MIRT887225	hsa-miR-2052	CLIP-seq
MIRT887226	hsa-miR-2115	CLIP-seq
MIRT887227	hsa-miR-2467-3p	CLIP-seq
MIRT887228	hsa-miR-3116	CLIP-seq
MIRT887229	hsa-miR-3133	CLIP-seq
MIRT887230	hsa-miR-3165	CLIP-seq
MIRT887231	hsa-miR-3173-5p	CLIP-seq
MIRT887232	hsa-miR-3175	CLIP-seq
MIRT887233	hsa-miR-3184	CLIP-seq
MIRT887234	hsa-miR-3192	CLIP-seq
MIRT887235	hsa-miR-324-3p	CLIP-seq
MIRT887236	hsa-miR-3612	CLIP-seq
MIRT887237	hsa-miR-3622b-5p	CLIP-seq
MIRT887238	hsa-miR-3665	CLIP-seq
MIRT887239	hsa-miR-3691-5p	CLIP-seq
MIRT887240	hsa-miR-423-5p	CLIP-seq
MIRT887241	hsa-miR-4269	CLIP-seq
MIRT887242	hsa-miR-4281	CLIP-seq
MIRT887243	hsa-miR-4283	CLIP-seq
MIRT887244	hsa-miR-4300	CLIP-seq
MIRT887214	hsa-miR-4305	CLIP-seq
MIRT887245	hsa-miR-4446-3p	CLIP-seq
MIRT887246	hsa-miR-4456	CLIP-seq
MIRT887247	hsa-miR-4462	CLIP-seq
MIRT887248	hsa-miR-4477b	CLIP-seq
MIRT887249	hsa-miR-4487	CLIP-seq
MIRT887250	hsa-miR-4489	CLIP-seq
MIRT887251	hsa-miR-4492	CLIP-seq
MIRT887252	hsa-miR-4498	CLIP-seq
MIRT887253	hsa-miR-4505	CLIP-seq
MIRT887254	hsa-miR-4514	CLIP-seq
MIRT887255	hsa-miR-4527	CLIP-seq
MIRT887256	hsa-miR-4639-5p	CLIP-seq
MIRT887257	hsa-miR-4642	CLIP-seq
MIRT887258	hsa-miR-4645-5p	CLIP-seq
MIRT887259	hsa-miR-4673	CLIP-seq
MIRT887260	hsa-miR-4683	CLIP-seq
MIRT887261	hsa-miR-4692	CLIP-seq
MIRT887215	hsa-miR-4699-3p	CLIP-seq
MIRT887262	hsa-miR-4706	CLIP-seq
MIRT887263	hsa-miR-4716-3p	CLIP-seq
MIRT887264	hsa-miR-4719	CLIP-seq
MIRT887265	hsa-miR-4720-5p	CLIP-seq
MIRT887266	hsa-miR-4721	CLIP-seq
MIRT887267	hsa-miR-4723-5p	CLIP-seq
MIRT887268	hsa-miR-4740-3p	CLIP-seq
MIRT887269	hsa-miR-4742-5p	CLIP-seq
MIRT887270	hsa-miR-4749-5p	CLIP-seq
MIRT887271	hsa-miR-4752	CLIP-seq
MIRT887272	hsa-miR-4753-5p	CLIP-seq
MIRT887273	hsa-miR-4799-3p	CLIP-seq
MIRT887274	hsa-miR-4802-5p	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT887276	hsa-miR-513b	CLIP-seq
MIRT887277	hsa-miR-514	CLIP-seq
MIRT887278	hsa-miR-514b-3p	CLIP-seq
MIRT887279	hsa-miR-610	CLIP-seq
MIRT887280	hsa-miR-615-3p	CLIP-seq
MIRT887281	hsa-miR-620	CLIP-seq
MIRT887282	hsa-miR-650	CLIP-seq
MIRT887283	hsa-miR-657	CLIP-seq
MIRT887284	hsa-miR-661	CLIP-seq
MIRT887285	hsa-miR-762	CLIP-seq
MIRT887286	hsa-miR-920	CLIP-seq
MIRT887287	hsa-miR-3650	CLIP-seq
MIRT887288	hsa-miR-3663-5p	CLIP-seq
MIRT887289	hsa-miR-371b-3p	CLIP-seq
MIRT887214	hsa-miR-4305	CLIP-seq
MIRT887290	hsa-miR-4641	CLIP-seq
MIRT887291	hsa-miR-4738-3p	CLIP-seq
MIRT887292	hsa-miR-4797-5p	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT887293	hsa-miR-520d-5p	CLIP-seq
MIRT887294	hsa-miR-524-5p	CLIP-seq
MIRT887295	hsa-miR-582-3p	CLIP-seq
MIRT887279	hsa-miR-610	CLIP-seq
MIRT887296	hsa-miR-759	CLIP-seq
MIRT2199561	hsa-miR-1285	CLIP-seq
MIRT2199562	hsa-miR-129-3p	CLIP-seq
MIRT2199563	hsa-miR-133a	CLIP-seq
MIRT2199564	hsa-miR-133b	CLIP-seq
MIRT887221	hsa-miR-141	CLIP-seq
MIRT887224	hsa-miR-200a	CLIP-seq
MIRT2199565	hsa-miR-3169	CLIP-seq
MIRT2199566	hsa-miR-3187-5p	CLIP-seq
MIRT2199567	hsa-miR-3189-3p	CLIP-seq
MIRT2199568	hsa-miR-3199	CLIP-seq
MIRT887287	hsa-miR-3650	CLIP-seq
MIRT887214	hsa-miR-4305	CLIP-seq
MIRT2199569	hsa-miR-4515	CLIP-seq
MIRT2199570	hsa-miR-4522	CLIP-seq
MIRT2199571	hsa-miR-4690-3p	CLIP-seq
MIRT2199572	hsa-miR-4715-3p	CLIP-seq
MIRT887264	hsa-miR-4719	CLIP-seq
MIRT2199573	hsa-miR-4727-5p	CLIP-seq
MIRT2199574	hsa-miR-4731-5p	CLIP-seq
MIRT2199575	hsa-miR-4769-3p	CLIP-seq
MIRT887292	hsa-miR-4797-5p	CLIP-seq
MIRT2199576	hsa-miR-483-3p	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT887276	hsa-miR-513b	CLIP-seq
MIRT887279	hsa-miR-610	CLIP-seq
MIRT2199577	hsa-miR-612	CLIP-seq
MIRT887296	hsa-miR-759	CLIP-seq
MIRT2199578	hsa-miR-922	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT2199563	hsa-miR-133a	CLIP-seq
MIRT2199564	hsa-miR-133b	CLIP-seq
MIRT887287	hsa-miR-3650	CLIP-seq
MIRT2446909	hsa-miR-370	CLIP-seq
MIRT2446910	hsa-miR-4466	CLIP-seq
MIRT2446911	hsa-miR-4793-5p	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT2446912	hsa-miR-675	CLIP-seq
MIRT2465088	hsa-miR-125a-5p	CLIP-seq
MIRT2465089	hsa-miR-125b	CLIP-seq
MIRT2465090	hsa-miR-4319	CLIP-seq
MIRT2446910	hsa-miR-4466	CLIP-seq
MIRT2465091	hsa-miR-4732-3p	CLIP-seq
MIRT887275	hsa-miR-509-3p	CLIP-seq
MIRT887279	hsa-miR-610	CLIP-seq
MIRT2465092	hsa-miR-670	CLIP-seq
MIRT2446912	hsa-miR-675	CLIP-seq
MIRT2678043	hsa-miR-1200	CLIP-seq
MIRT2678044	hsa-miR-3127-5p	CLIP-seq
MIRT2678045	hsa-miR-3652	CLIP-seq
MIRT2678046	hsa-miR-3918	CLIP-seq
MIRT2678047	hsa-miR-4324	CLIP-seq
MIRT2678048	hsa-miR-4430	CLIP-seq
MIRT887245	hsa-miR-4446-3p	CLIP-seq
MIRT887251	hsa-miR-4492	CLIP-seq
MIRT887252	hsa-miR-4498	CLIP-seq
MIRT2678049	hsa-miR-544b	CLIP-seq
MIRT887285	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0034383	Process	Low-density lipoprotein particle clearance	TAS
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	TAS
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0106435	Function	Carboxylesterase activity	IEA

Other IDs

• MIM: 605279
• HGNC: 1865
• e!Ensembl: ENSG00000172828

Protein

• UniProt ID: Q6UWW8
• Protein name: Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)
• Protein function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptoth
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00135	COesterase	32 → 547	Carboxylesterase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}.
• Sequence:

  MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVF
  LGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSV
  SEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRL
  GVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVL
  SPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEE
  LVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLD
  TMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINV
  PTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRL
  AFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFR
  EAWMQFWSETLPSKIQQWHQKQKNRKAQEDL

• Sequence length: 571

Pathways

Reactome:

Phase I - Functionalization of compounds
LDL clearance