PPP1R13B (protein phosphatase 1 regulatory subunit 13B)

Gene

• Entrez ID: 23368
• Gene name: Protein phosphatase 1 regulatory subunit 13B
• Gene symbol: PPP1R13B
• Synonyms (NCBI Gene): ASPP1, p53BP2-like, p85
• Chromosome: 14
• Chromosome location: 14q32.33
• Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the indu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006486	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	19079265
MIRT006486	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	19079265
MIRT006487	hsa-miR-29c-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006486	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	19079265
MIRT006486	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	19079265
MIRT006487	hsa-miR-29c-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT006485	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	19079265
MIRT047417	hsa-miR-10b-5p	CLASH	23622248
MIRT045828	hsa-miR-138-5p	CLASH	23622248
MIRT040984	hsa-miR-505-3p	CLASH	23622248
MIRT039385	hsa-miR-421	CLASH	23622248
MIRT039041	hsa-miR-766-3p	CLASH	23622248
MIRT038764	hsa-miR-93-3p	CLASH	23622248
MIRT1255823	hsa-miR-1253	CLIP-seq
MIRT1255824	hsa-miR-1285	CLIP-seq
MIRT1255825	hsa-miR-1302	CLIP-seq
MIRT1255826	hsa-miR-1304	CLIP-seq
MIRT1255827	hsa-miR-139-5p	CLIP-seq
MIRT1255828	hsa-miR-141	CLIP-seq
MIRT1255829	hsa-miR-147	CLIP-seq
MIRT1255830	hsa-miR-148a	CLIP-seq
MIRT1255831	hsa-miR-148b	CLIP-seq
MIRT1255832	hsa-miR-152	CLIP-seq
MIRT1255833	hsa-miR-197	CLIP-seq
MIRT1255834	hsa-miR-200a	CLIP-seq
MIRT1255835	hsa-miR-214	CLIP-seq
MIRT1255836	hsa-miR-2467-5p	CLIP-seq
MIRT1255837	hsa-miR-2861	CLIP-seq
MIRT1255838	hsa-miR-3121-5p	CLIP-seq
MIRT1255839	hsa-miR-3150b-3p	CLIP-seq
MIRT1255840	hsa-miR-3179	CLIP-seq
MIRT1255841	hsa-miR-3185	CLIP-seq
MIRT1255842	hsa-miR-3187-5p	CLIP-seq
MIRT1255843	hsa-miR-3188	CLIP-seq
MIRT1255844	hsa-miR-3607-5p	CLIP-seq
MIRT1255845	hsa-miR-3619-5p	CLIP-seq
MIRT1255846	hsa-miR-3654	CLIP-seq
MIRT1255847	hsa-miR-3911	CLIP-seq
MIRT1255848	hsa-miR-3941	CLIP-seq
MIRT1255849	hsa-miR-3975	CLIP-seq
MIRT1255850	hsa-miR-412	CLIP-seq
MIRT1255851	hsa-miR-4276	CLIP-seq
MIRT1255852	hsa-miR-4282	CLIP-seq
MIRT1255853	hsa-miR-4291	CLIP-seq
MIRT1255854	hsa-miR-4298	CLIP-seq
MIRT1255855	hsa-miR-4312	CLIP-seq
MIRT1255856	hsa-miR-4434	CLIP-seq
MIRT1255857	hsa-miR-4448	CLIP-seq
MIRT1255858	hsa-miR-4505	CLIP-seq
MIRT1255859	hsa-miR-4516	CLIP-seq
MIRT1255860	hsa-miR-4638-3p	CLIP-seq
MIRT1255861	hsa-miR-4648	CLIP-seq
MIRT1255862	hsa-miR-4654	CLIP-seq
MIRT1255863	hsa-miR-466	CLIP-seq
MIRT1255864	hsa-miR-4672	CLIP-seq
MIRT1255865	hsa-miR-4697-3p	CLIP-seq
MIRT1255866	hsa-miR-4711-5p	CLIP-seq
MIRT1255867	hsa-miR-4747-5p	CLIP-seq
MIRT1255868	hsa-miR-4761-5p	CLIP-seq
MIRT1255869	hsa-miR-4769-5p	CLIP-seq
MIRT1255870	hsa-miR-4784	CLIP-seq
MIRT1255871	hsa-miR-4790-3p	CLIP-seq
MIRT1255872	hsa-miR-4797-5p	CLIP-seq
MIRT1255873	hsa-miR-485-5p	CLIP-seq
MIRT1255874	hsa-miR-503	CLIP-seq
MIRT1255875	hsa-miR-512-3p	CLIP-seq
MIRT1255876	hsa-miR-513a-3p	CLIP-seq
MIRT1255877	hsa-miR-548v	CLIP-seq
MIRT1255878	hsa-miR-587	CLIP-seq
MIRT1255879	hsa-miR-595	CLIP-seq
MIRT1255880	hsa-miR-601	CLIP-seq
MIRT1255881	hsa-miR-603	CLIP-seq
MIRT1255882	hsa-miR-612	CLIP-seq
MIRT1255883	hsa-miR-644	CLIP-seq
MIRT1255884	hsa-miR-661	CLIP-seq
MIRT1255885	hsa-miR-761	CLIP-seq
MIRT1255886	hsa-miR-765	CLIP-seq
MIRT1255887	hsa-miR-9	CLIP-seq
MIRT1255888	hsa-miR-922	CLIP-seq
MIRT2075384	hsa-miR-1184	CLIP-seq
MIRT2075385	hsa-miR-1207-5p	CLIP-seq
MIRT2075386	hsa-miR-1255a	CLIP-seq
MIRT2075387	hsa-miR-1255b	CLIP-seq
MIRT2075388	hsa-miR-128	CLIP-seq
MIRT2075389	hsa-miR-1301	CLIP-seq
MIRT2075390	hsa-miR-1343	CLIP-seq
MIRT2075391	hsa-miR-136	CLIP-seq
MIRT2075392	hsa-miR-150	CLIP-seq
MIRT2075393	hsa-miR-182	CLIP-seq
MIRT2075394	hsa-miR-1910	CLIP-seq
MIRT2075395	hsa-miR-22	CLIP-seq
MIRT1255836	hsa-miR-2467-5p	CLIP-seq
MIRT1255837	hsa-miR-2861	CLIP-seq
MIRT2075396	hsa-miR-3074-5p	CLIP-seq
MIRT2075397	hsa-miR-3124-3p	CLIP-seq
MIRT2075398	hsa-miR-3127-5p	CLIP-seq
MIRT2075399	hsa-miR-3141	CLIP-seq
MIRT2075400	hsa-miR-3148	CLIP-seq
MIRT1255843	hsa-miR-3188	CLIP-seq
MIRT2075401	hsa-miR-3189-3p	CLIP-seq
MIRT2075402	hsa-miR-345	CLIP-seq
MIRT2075403	hsa-miR-3612	CLIP-seq
MIRT2075404	hsa-miR-361-3p	CLIP-seq
MIRT2075405	hsa-miR-3659	CLIP-seq
MIRT2075406	hsa-miR-3690	CLIP-seq
MIRT2075407	hsa-miR-3960	CLIP-seq
MIRT1255849	hsa-miR-3975	CLIP-seq
MIRT2075408	hsa-miR-4254	CLIP-seq
MIRT2075409	hsa-miR-4268	CLIP-seq
MIRT2075410	hsa-miR-4270	CLIP-seq
MIRT2075411	hsa-miR-432	CLIP-seq
MIRT2075412	hsa-miR-4323	CLIP-seq
MIRT2075413	hsa-miR-4441	CLIP-seq
MIRT2075414	hsa-miR-4443	CLIP-seq
MIRT1255857	hsa-miR-4448	CLIP-seq
MIRT2075415	hsa-miR-4470	CLIP-seq
MIRT2075416	hsa-miR-4471	CLIP-seq
MIRT2075417	hsa-miR-4479	CLIP-seq
MIRT2075418	hsa-miR-455-3p	CLIP-seq
MIRT2075419	hsa-miR-4634	CLIP-seq
MIRT2075420	hsa-miR-4650-5p	CLIP-seq
MIRT2075421	hsa-miR-4658	CLIP-seq
MIRT2075422	hsa-miR-4660	CLIP-seq
MIRT2075423	hsa-miR-4669	CLIP-seq
MIRT2075424	hsa-miR-4680-3p	CLIP-seq
MIRT2075425	hsa-miR-4690-5p	CLIP-seq
MIRT2075426	hsa-miR-4691-3p	CLIP-seq
MIRT2075427	hsa-miR-4713-5p	CLIP-seq
MIRT2075428	hsa-miR-4731-5p	CLIP-seq
MIRT1255868	hsa-miR-4761-5p	CLIP-seq
MIRT2075429	hsa-miR-4763-3p	CLIP-seq
MIRT1255873	hsa-miR-485-5p	CLIP-seq
MIRT2075430	hsa-miR-486-3p	CLIP-seq
MIRT2075431	hsa-miR-5047	CLIP-seq
MIRT1255875	hsa-miR-512-3p	CLIP-seq
MIRT2075432	hsa-miR-532-3p	CLIP-seq
MIRT2075433	hsa-miR-539	CLIP-seq
MIRT2075434	hsa-miR-548k	CLIP-seq
MIRT2075435	hsa-miR-574-5p	CLIP-seq
MIRT1255879	hsa-miR-595	CLIP-seq
MIRT2075436	hsa-miR-650	CLIP-seq
MIRT2075437	hsa-miR-875-3p	CLIP-seq
MIRT2301985	hsa-miR-106a	CLIP-seq
MIRT2301986	hsa-miR-106b	CLIP-seq
MIRT2075384	hsa-miR-1184	CLIP-seq
MIRT2301987	hsa-miR-1225-5p	CLIP-seq
MIRT2301988	hsa-miR-1283	CLIP-seq
MIRT1255824	hsa-miR-1285	CLIP-seq
MIRT2075389	hsa-miR-1301	CLIP-seq
MIRT2075390	hsa-miR-1343	CLIP-seq
MIRT1255827	hsa-miR-139-5p	CLIP-seq
MIRT1255830	hsa-miR-148a	CLIP-seq
MIRT1255831	hsa-miR-148b	CLIP-seq
MIRT2075392	hsa-miR-150	CLIP-seq
MIRT1255832	hsa-miR-152	CLIP-seq
MIRT2301989	hsa-miR-1587	CLIP-seq
MIRT2301990	hsa-miR-17	CLIP-seq
MIRT2301991	hsa-miR-1913	CLIP-seq
MIRT2301992	hsa-miR-1914	CLIP-seq
MIRT1255833	hsa-miR-197	CLIP-seq
MIRT2301993	hsa-miR-20a	CLIP-seq
MIRT2301994	hsa-miR-20b	CLIP-seq
MIRT1255835	hsa-miR-214	CLIP-seq
MIRT2075395	hsa-miR-22	CLIP-seq
MIRT2075396	hsa-miR-3074-5p	CLIP-seq
MIRT2301995	hsa-miR-3115	CLIP-seq
MIRT2075397	hsa-miR-3124-3p	CLIP-seq
MIRT2075400	hsa-miR-3148	CLIP-seq
MIRT1255842	hsa-miR-3187-5p	CLIP-seq
MIRT2301996	hsa-miR-3189-5p	CLIP-seq
MIRT2301997	hsa-miR-3199	CLIP-seq
MIRT2301998	hsa-miR-324-3p	CLIP-seq
MIRT2301999	hsa-miR-329	CLIP-seq
MIRT2302000	hsa-miR-3609	CLIP-seq
MIRT2075403	hsa-miR-3612	CLIP-seq
MIRT1255845	hsa-miR-3619-5p	CLIP-seq
MIRT2302001	hsa-miR-3622a-3p	CLIP-seq
MIRT2302002	hsa-miR-3622b-3p	CLIP-seq
MIRT2302003	hsa-miR-362-3p	CLIP-seq
MIRT2075406	hsa-miR-3690	CLIP-seq
MIRT2302004	hsa-miR-378g	CLIP-seq
MIRT1255848	hsa-miR-3941	CLIP-seq
MIRT2302005	hsa-miR-3944-3p	CLIP-seq
MIRT1255850	hsa-miR-412	CLIP-seq
MIRT2075408	hsa-miR-4254	CLIP-seq
MIRT2302006	hsa-miR-4267	CLIP-seq
MIRT2075409	hsa-miR-4268	CLIP-seq
MIRT1255853	hsa-miR-4291	CLIP-seq
MIRT1255856	hsa-miR-4434	CLIP-seq
MIRT1255857	hsa-miR-4448	CLIP-seq
MIRT2302007	hsa-miR-4468	CLIP-seq
MIRT2075415	hsa-miR-4470	CLIP-seq
MIRT2302008	hsa-miR-4481	CLIP-seq
MIRT2302009	hsa-miR-4486	CLIP-seq
MIRT2302010	hsa-miR-4492	CLIP-seq
MIRT2302011	hsa-miR-4498	CLIP-seq
MIRT2302012	hsa-miR-4506	CLIP-seq
MIRT2302013	hsa-miR-4512	CLIP-seq
MIRT1255859	hsa-miR-4516	CLIP-seq
MIRT2302014	hsa-miR-4531	CLIP-seq
MIRT2302015	hsa-miR-4655-5p	CLIP-seq
MIRT2302016	hsa-miR-4656	CLIP-seq
MIRT2302017	hsa-miR-4659a-3p	CLIP-seq
MIRT2302018	hsa-miR-4659b-3p	CLIP-seq
MIRT2075422	hsa-miR-4660	CLIP-seq
MIRT2302019	hsa-miR-4675	CLIP-seq
MIRT1255865	hsa-miR-4697-3p	CLIP-seq
MIRT2075427	hsa-miR-4713-5p	CLIP-seq
MIRT2302020	hsa-miR-4741	CLIP-seq
MIRT2302021	hsa-miR-4745-5p	CLIP-seq
MIRT2302022	hsa-miR-4758-3p	CLIP-seq
MIRT1255868	hsa-miR-4761-5p	CLIP-seq
MIRT2302023	hsa-miR-4787-5p	CLIP-seq
MIRT2302024	hsa-miR-4796-3p	CLIP-seq
MIRT1255874	hsa-miR-503	CLIP-seq
MIRT2075431	hsa-miR-5047	CLIP-seq
MIRT1255875	hsa-miR-512-3p	CLIP-seq
MIRT2302025	hsa-miR-519d	CLIP-seq
MIRT2075432	hsa-miR-532-3p	CLIP-seq
MIRT2075433	hsa-miR-539	CLIP-seq
MIRT2302026	hsa-miR-548ah	CLIP-seq
MIRT2075434	hsa-miR-548k	CLIP-seq
MIRT1255877	hsa-miR-548v	CLIP-seq
MIRT2302027	hsa-miR-569	CLIP-seq
MIRT2302028	hsa-miR-570	CLIP-seq
MIRT1255881	hsa-miR-603	CLIP-seq
MIRT1255882	hsa-miR-612	CLIP-seq
MIRT2302029	hsa-miR-619	CLIP-seq
MIRT2302030	hsa-miR-624	CLIP-seq
MIRT2075436	hsa-miR-650	CLIP-seq
MIRT2302031	hsa-miR-759	CLIP-seq
MIRT1255885	hsa-miR-761	CLIP-seq
MIRT2302032	hsa-miR-762	CLIP-seq
MIRT2075437	hsa-miR-875-3p	CLIP-seq
MIRT2302033	hsa-miR-885-3p	CLIP-seq
MIRT1255888	hsa-miR-922	CLIP-seq
MIRT2302034	hsa-miR-93	CLIP-seq
MIRT2392918	hsa-miR-3120-5p	CLIP-seq
MIRT2075415	hsa-miR-4470	CLIP-seq
MIRT2075427	hsa-miR-4713-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	15706352;21479363

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002039	Function	P53 binding	IBA
GO:0002039	Function	P53 binding	IEA
GO:0005515	Function	Protein binding	IPI	11684014, 14729977, 15231748, 17043677, 21513714, 21998301, 22321011, 24366813, 25416956, 28330616, 28514442, 31413325, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11684014
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	15782125
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006915	Process	Apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0045786	Process	Negative regulation of cell cycle	IEA
GO:0045786	Process	Negative regulation of cell cycle	TAS	14729977
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11684014
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IEA

Other IDs

• MIM: 606455
• HGNC: 14950
• e!Ensembl: ENSG00000088808

Protein

• UniProt ID: Q96KQ4
• Protein name: Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
• Protein function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptoti
• PDB: 6HL5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	920 → 952	Ankyrin repeat	Repeat
  PF00023	Ank	953 → 985	Ankyrin repeat	Repeat
  PF00018	SH3_1	1025 → 1073	SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Reduced expression in breast carcinomas expressing a wild-type TP53 protein. {ECO:0000269|PubMed:11684014}.
• Sequence:

  MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH
  MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVG
  NPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLK
  ERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQ
  QLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRN
  MEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPV
  LGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK
  QGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLE
  RRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPA
  GDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA
  LNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADG
  STVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP
  NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP
  LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA
  PSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE
  FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC
  AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN
  KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP
  RIKPRQRTLA

• Sequence length: 1090

Pathways

Reactome:

Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Childhood-onset schizophrenia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	37354922	★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Inhibit	21102414	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	28103919	★☆☆☆☆ Found in Text Mining only
Gestational Trophoblastic Disease	Associate	21102414, 31615473	★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Inhibit	21102414	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	38195541	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	28103919	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	21041410	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	21041411, 26595804	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	38195541	★☆☆☆☆ Found in Text Mining only